Linfotoxina beta
(Redirección desde «LTB»)
Linfotoxina beta (superfamilia TNF, membro 3)
| |
| Identificadores | |
| Símbolo | LTB |
| Símbolos alt. | TNFC |
| Entrez | 4050 |
| HUGO | 6711 |
| OMIM | |
| RefSeq | NM_002341 |
| UniProt | Q06643 |
| Outros datos | |
| Locus | Cr. 6 p21.3 |
A linfotoxina beta (LT-beta) tamén chamada factor de necrose tumoral C (TNF-C) é unha proteína con funcións reguladoras inmunitarias, que nos humanos está codificada no xene LTB do cromosoma 6.[1][2][3]
Función editar
A linfotoxina beta é un tipo de proteína de membrana de tipo II da familia do factor de necrose tumoral. Funciona ancorando a linfotoxina alfa á superficie da célula por medio da formación dun heterotrímero. A forma predominante da superficie dos linfocitos é o complexo linfotoxina alfa 1/beta 2 (é dicir, 1 molécula alfa/2 moléculas beta) e este complexo é o ligando primario do receptor da linfotoxina beta. Un complexo menos frecuente é o linfotoxina alfa 2/beta 1. A linfotoxina beta é un indutor do sistema de resposta inflamatoria e está implicada no desenvolvemento normal do tecido linfoide. A isoforma b da linfotoxina beta non pode formar complexo coa linfotoxina alfa, o que suxire que hai unha función para a linfotoxina beta que é independente da linfotoxina alfa. O splicing alternativo dá lugar a moitas variantes de transcrición que codifican diferentres isoformas.[3]
Interaccións editar
A linfotoxina beta presenta interaccións coa linfotoxina alfa.[4][5][6]
Notas editar
- ↑ Browning JL, Ngam-ek A, Lawton P, DeMarinis J, Tizard R, Chow EP, Hession C, O'Brine-Greco B, Foley SF, Ware CF (April 1993). "Lymphotoxin beta, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface". Cell 72 (6): 847–56. PMID 7916655. doi:10.1016/0092-8674(93)90574-A.
- ↑ Browning JL, Androlewicz MJ, Ware CF (September 1991). "Lymphotoxin and an associated 33-kDa glycoprotein are expressed on the surface of an activated human T cell hybridoma". J Immunol 147 (4): 1230–7. PMID 1714477.
- ↑ 3,0 3,1 "Entrez Gene: LTB lymphotoxin beta (TNF superfamily, member 3)".
- ↑ Williams-Abbott, L; Walter B N; Cheung T C; Goh C R; Porter A G; Ware C F (August 1997). "The lymphotoxin-alpha (LTalpha) subunit is essential for the assembly, but not for the receptor specificity, of the membrane-anchored LTalpha1beta2 heterotrimeric ligand". J. Biol. Chem. (UNITED STATES) 272 (31): 19451–6. ISSN 0021-9258. PMID 9235946. doi:10.1074/jbc.272.31.19451.
- ↑ Browning, J L; Sizing I D, Lawton P, Bourdon P R, Rennert P D, Majeau G R, Ambrose C M, Hession C, Miatkowski K, Griffiths D A, Ngam-ek A, Meier W, Benjamin C D, Hochman P S (October 1997). "Characterization of lymphotoxin-alpha beta complexes on the surface of mouse lymphocytes". J. Immunol. (UNITED STATES) 159 (7): 3288–98. ISSN 0022-1767. PMID 9317127.
- ↑ Browning, J L; Dougas I; Ngam-ek A; Bourdon P R; Ehrenfels B N; Miatkowski K; Zafari M; Yampaglia A M; Lawton P; Meier W (January 1995). "Characterization of surface lymphotoxin forms. Use of specific monoclonal antibodies and soluble receptors". J. Immunol. (UNITED STATES) 154 (1): 33–46. ISSN 0022-1767. PMID 7995952.
Véxase tamén editar
Outros artigos editar
Bibliografía editar
- Messer G, Spengler U, Jung MC; et al. (1991). "Polymorphic structure of the tumor necrosis factor (TNF) locus: an NcoI polymorphism in the first intron of the human TNF-beta gene correlates with a variant amino acid in position 26 and a reduced level of TNF-beta production.". J. Exp. Med. 173 (1): 209–19. PMC 2118757. PMID 1670638. doi:10.1084/jem.173.1.209.
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- Holzinger I, de Baey A, Messer G; et al. (1995). "Cloning and genomic characterization of LST1: a new gene in the human TNF region.". Immunogenetics 42 (5): 315–22. PMID 7590964. doi:10.1007/BF00179392.
- Peelman LJ, Chardon P, Nunes M; et al. (1995). "The BAT1 gene in the MHC encodes an evolutionarily conserved putative nuclear RNA helicase of the DEAD family.". Genomics 26 (2): 210–8. PMID 7601445. doi:10.1016/0888-7543(95)80203-X.
- Browning JL, Dougas I, Ngam-ek A; et al. (1995). "Characterization of surface lymphotoxin forms. Use of specific monoclonal antibodies and soluble receptors.". J. Immunol. 154 (1): 33–46. PMID 7995952.
- Albertella MR, Campbell RD (1994). "Characterization of a novel gene in the human major histocompatibility complex that encodes a potential new member of the I kappa B family of proteins.". Hum. Mol. Genet. 3 (5): 793–9. PMID 8081366. doi:10.1093/hmg/3.5.793.
- Iris FJ, Bougueleret L, Prieur S; et al. (1993). "Dense Alu clustering and a potential new member of the NF kappa B family within a 90 kilobase HLA class III segment.". Nat. Genet. 3 (2): 137–45. PMID 8499947. doi:10.1038/ng0293-137.
- Nakamura T, Tashiro K, Nazarea M; et al. (1996). "The murine lymphotoxin-beta receptor cDNA: isolation by the signal sequence trap and chromosomal mapping.". Genomics 30 (2): 312–9. PMID 8586432. doi:10.1006/geno.1995.9872.
- Utans U, Quist WC, McManus BM; et al. (1996). "Allograft inflammatory factory-1. A cytokine-responsive macrophage molecule expressed in transplanted human hearts.". Transplantation 61 (9): 1387–92. PMID 8629302. doi:10.1097/00007890-199605150-00018.
- Nalabolu SR, Shukla H, Nallur G; et al. (1997). "Genes in a 220-kb region spanning the TNF cluster in human MHC.". Genomics 31 (2): 215–22. PMID 8824804. doi:10.1006/geno.1996.0034.
- Laham N, Van Dunné F, Abraham LJ; et al. (1997). "Tumor necrosis factor-beta in human pregnancy and labor.". J. Reprod. Immunol. 33 (1): 53–69. PMID 9185077. doi:10.1016/S0165-0378(97)01012-7.
- Warzocha K, Renard N, Charlot C; et al. (1997). "Identification of two lymphotoxin beta isoforms expressed in human lymphoid cell lines and non-Hodgkin's lymphomas.". Biochem. Biophys. Res. Commun. 238 (2): 273–6. PMID 9299492. doi:10.1006/bbrc.1997.7277.
- Browning JL, Sizing ID, Lawton P; et al. (1997). "Characterization of lymphotoxin-alpha beta complexes on the surface of mouse lymphocytes.". J. Immunol. 159 (7): 3288–98. PMID 9317127.
- de Baey A, Fellerhoff B, Maier S; et al. (1998). "Complex expression pattern of the TNF region gene LST1 through differential regulation, initiation, and alternative splicing.". Genomics 45 (3): 591–600. PMID 9367684. doi:10.1006/geno.1997.4963.
- Shiina T, Tamiya G, Oka A; et al. (1998). "Nucleotide sequencing analysis of the 146-kilobase segment around the IkBL and MICA genes at the centromeric end of the HLA class I region.". Genomics 47 (3): 372–82. PMID 9480751. doi:10.1006/geno.1997.5114.
- Bodor J, Habener JF (1998). "Role of transcriptional repressor ICER in cyclic AMP-mediated attenuation of cytokine gene expression in human thymocytes.". J. Biol. Chem. 273 (16): 9544–51. PMID 9545284. doi:10.1074/jbc.273.16.9544.
- Neville MJ, Campbell RD (1999). "A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC.". J. Immunol. 162 (8): 4745–54. PMID 10202016.