Peroxirredoxina 2

PRDX2
Estruturas dispoñibles
PDB	Buscar ortólogos: PDBe, RCSB Lista de códigos PDB 1QMV ;
Identificadores
Nomenclatura	Outros nomes PRDX2, HEL-S-2a, NKEF-B, NKEFB, PRP, PRX2, PRXII, PTX1, TDPX1, TPX1, TSA, Peroxirredoxina-2 ;
Símbolos	PRDX2 (HGNC: 9353) PRDX2, HEL-S-2a, NKEF-B, NKEFB, PRP, PRX2, PRXII, PTX1, TDPX1, TPX1, TSA, Peroxirredoxina-2
Identificadores; externos	OMIM: 600538 ; MGI: 109486 ; HomoloGene: 21182 ; EBI: PRDX2; GeneCards: Xene PRDX2; UniProt: PRDX2;
Locus	Cr. 19 p13.13
Ontoloxía Xénica	Referencias: AmiGO / QuickGO
	Referencias: AmiGO / QuickGO
Padrón de expresión de ARNm
	Máis información
Ortólogos
Especies
Humano	Rato
Entrez
7001	21672
Ensembl
Véxase HS	Véxase MM
UniProt
P32119	Q61171
RefSeq; (ARNm)
NM_181738	NM_011563
RefSeq; (proteína) NCBI
NP_005800	NP_001304314
Localización (UCSC)
Cr. 19:; 12.8 – 12.8 Mb	Cr. 8:; 85.7 – 85.7 Mb
PubMed (Busca)
7001 ;	21672

A peroxirredoxina 2 é unha proteína oxidorredutase que nos humanos está codificada no xene PRDX2 do cromosoma 19.^[1]^[2]

O xene PRDX2 codifica un membro da familia da peroxirredoxina de encimas antioxidantes, os cales reducen o peróxido de hidróxeno a alquil hidroperóxidos. A proteína codificada pode xogar un papel antioxidante protector nas células e pode contribuír á actividade antiviral das células T CD8+. Pode ter un efecto proliferativo e intervir no desenvolvemento e progresión do cancro. A súa estrutura cristalina resolveuse a 0,27 nm (= 2,7 ángstroms). As variantes de transcrición constitúen distintas isoformas que foron identificadas para este xene.^[2]

Notas editar

↑ Pahl P, Berger R, Hart I, Chae HZ, Rhee SG, Patterson D (agosto de 1995). "Localization of TDPX1, a human homologue of the yeast thioredoxin-dependent peroxide reductase gene (TPX), to chromosome 13q12". Genomics 26 (3): 602–6. PMID 7607688. doi:10.1016/0888-7543(95)80183-M.
↑ ^2,0 ^2,1 "Entrez Gene: PRDX2 peroxiredoxin 2".

Véxase tamén editar

Bibliografía editar

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Cha MK, Yun CH, Kim IH (2000). "Interaction of human thiol-specific antioxidant protein 1 with erythrocyte plasma membrane.". Biochemistry 39 (23): 6944–50. PMID 10841776. doi:10.1021/bi000034j.
Schröder E, Littlechild JA, Lebedev AA, et al. (2000). "Crystal structure of decameric 2-Cys peroxiredoxin from human erythrocytes at 1.7 A resolution.". Structure 8 (6): 605–15. PMID 10873855. doi:10.1016/S0969-2126(00)00147-7.
Harris JR, Schröder E, Isupov MN, et al. (2001). "Comparison of the decameric structure of peroxiredoxin-II by transmission electron microscopy and X-ray crystallography.". Biochim. Biophys. Acta 1547 (2): 221–34. PMID 11410278. doi:10.1016/s0167-4838(01)00184-4.
Noh DY, Ahn SJ, Lee RA, et al. (2001). "Overexpression of peroxiredoxin in human breast cancer.". Anticancer Res. 21 (3B): 2085–90. PMID 11497302.
Kim SH, Fountoulakis M, Cairns N, Lubec G (2002). "Protein levels of human peroxiredoxin subtypes in brains of patients with Alzheimer's disease and Down syndrome.". J. Neural Transm. Suppl. (61): 223–35. ISBN 978-3-211-83704-7. PMID 11771746. doi:10.1007/978-3-7091-6262-0_18.
Rabilloud T, Heller M, Gasnier F, et al. (2002). "Proteomics analysis of cellular response to oxidative stress. Evidence for in vivo overoxidation of peroxiredoxins at their active site.". J. Biol. Chem. 277 (22): 19396–401. PMID 11904290. doi:10.1074/jbc.M106585200.
Anahory T, Dechaud H, Bennes R, et al. (2002). "Identification of new proteins in follicular fluid of mature human follicles.". Electrophoresis 23 (7–8): 1197–202. PMID 11981869. doi:10.1002/1522-2683(200204)23:7/8<1197::AID-ELPS1197>3.0.CO;2-2.
Shen C, Nathan C (2002). "Nonredundant antioxidant defense by multiple two-cysteine peroxiredoxins in human prostate cancer cells.". Mol. Med. 8 (2): 95–102. PMC 2039972. PMID 12080185. doi:10.1007/BF03402079.
Geiben-Lynn R, Kursar M, Brown NV, et al. (2003). "HIV-1 antiviral activity of recombinant natural killer cell enhancing factors, NKEF-A and NKEF-B, members of the peroxiredoxin family.". J. Biol. Chem. 278 (3): 1569–74. PMID 12421812. doi:10.1074/jbc.M209964200.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899.

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[pmid7607688-1] Pahl P, Berger R, Hart I, Chae HZ, Rhee SG, Patterson D (agosto de 1995). "Localization of TDPX1, a human homologue of the yeast thioredoxin-dependent peroxide reductase gene (TPX), to chromosome 13q12". Genomics 26 (3): 602–6. PMID 7607688. doi:10.1016/0888-7543(95)80183-M.

[entrez-2] 2,0 ^2,1 "Entrez Gene: PRDX2 peroxiredoxin 2".

[1]

[2]