Apolipoproteína C4
A apolipoproteína C4 (tamén chamada apolipoproteína C-IV ou apo C-IV entre outros nomes) é unha proteína que nos humanos está codificada no xene APOC4 do cromosoma 19.[1][2]
| APOC4 | |||
|---|---|---|---|
| Estruturas dispoñibles | |||
| PDB | Buscar ortólogos: PDBe, RCSB | ||
| Identificadores | |||
| Nomenclatura | Outros nomes
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| Símbolo | APOC4 (HGNC: 611) | ||
| Identificadores externos | |||
| Locus | Cr. 19 q13.32 | ||
| Ortólogos | |||
| Especies |
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| Entrez |
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| Ensembl |
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| UniProt |
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| RefSeq (ARNm) |
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| RefSeq (proteína) NCBI |
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| Localización (UCSC) |
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| PubMed (Busca) |
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Función editar
APOC4 é un membro da familia de xenes da apolipoproteína C. Exprésase no fígado e ten unha estrutura proteica predita característica das proteínas dos outros xenes da familia. APOC4 é un xene de 3,3-kb que consta de 3 exóns e 2 intróns; está localizado a 0,5 kb do extremo 5' do xene APOC2.[1]
Notas editar
- ↑ 1,0 1,1 "Entrez Gene: apolipoprotein C-IV".
- ↑ Allan CM, Walker D, Segrest JP, Taylor JM (xullo de 1995). "Identification and characterization of a new human gene (APOC4) in the apolipoprotein E, C-I, and C-II gene locus". Genomics 28 (2): 291–300. PMID 8530039. doi:10.1006/geno.1995.1144.
Véxase tamén editar
Ligazóns externas editar
- Localización no xenoma humano de APOC4 e páxina con detalles sobre o xene APOC4 no UCSC Genome Browser.
Bibliografía editar
- Kim E, Li K, Lieu C, et al. (2008). "Expression of apolipoprotein C-IV is regulated by Ku antigen/peroxisome proliferator-activated receptor gamma complex and correlates with liver steatosis.". J. Hepatol. 49 (5): 787–98. PMC 2644636. PMID 18809223. doi:10.1016/j.jhep.2008.06.029.
- Burkhardt R, Kenny EE, Lowe JK, et al. (2008). "Common SNPs in HMGCR in micronesians and whites associated with LDL-cholesterol levels affect alternative splicing of exon13". Arterioscler. Thromb. Vasc. Biol. 28 (11): 2078–84. PMC 2764366. PMID 18802019. doi:10.1161/ATVBAHA.108.172288.
- Willer CJ, Sanna S, Jackson AU, et al. (2008). "Newly identified loci that influence lipid concentrations and risk of coronary artery disease". Nat. Genet. 40 (2): 161–9. PMC 5206900. PMID 18193043. doi:10.1038/ng.76.
- Mak PA, Laffitte BA, Desrumaux C, et al. (2002). "Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta". J. Biol. Chem. 277 (35): 31900–8. PMID 12032151. doi:10.1074/jbc.M202993200.
- Liu T, Qian WJ, Gritsenko MA, et al. (2005). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. PMC 1850943. PMID 16335952. doi:10.1021/pr0502065.
- Kathiresan S, Willer CJ, Peloso GM, et al. (2009). "Common variants at 30 loci contribute to polygenic dyslipidemia". Nat. Genet. 41 (1): 56–65. PMC 2881676. PMID 19060906. doi:10.1038/ng.291.
- Mosbruger TL, Duggal P, Goedert JJ, et al. (2010). "Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus". J. Infect. Dis. 201 (9): 1371–80. PMC 2853721. PMID 20331378. doi:10.1086/651606.
- Ken-Dror G, Talmud PJ, Humphries SE, Drenos F (2010). "APOE/C1/C4/C2 gene cluster genotypes, haplotypes and lipid levels in prospective Coronary Heart Disease Risk among UK healthy men". Molecular Medicine 16 (9–10): 389–99. PMC 2935949. PMID 20498921. doi:10.2119/molmed.2010.00044.
- Marques-Vidal P, Bochud M, Paccaud F, et al. (2010). "No interaction between alcohol consumption and HDL-related genes on HDL cholesterol levels". Atherosclerosis 211 (2): 551–7. PMID 20430392. doi:10.1016/j.atherosclerosis.2010.04.001.
- Talmud PJ, Drenos F, Shah S, et al. (2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. PMC 2775832. PMID 19913121. doi:10.1016/j.ajhg.2009.10.014.
- Drenos F, Talmud PJ, Casas JP, et al. (2009). "Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk". Hum. Mol. Genet. 18 (12): 2305–16. PMC 2685759. PMID 19336475. doi:10.1093/hmg/ddp159.
- Kathiresan S, Melander O, Guiducci C, et al. (2008). "Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans". Nat. Genet. 40 (2): 189–97. PMC 2682493. PMID 18193044. doi:10.1038/ng.75.
- Mancone C, Amicone L, Fimia GM, et al. (2007). "Proteomic analysis of human very low-density lipoprotein by two-dimensional gel electrophoresis and MALDI-TOF/TOF". Proteomics 7 (1): 143–54. PMID 17154273. doi:10.1002/pmic.200600339.
- Lowe JK, Maller JB, Pe'er I, et al. (2009). Gibson G, ed. "Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae". PLOS Genet. 5 (2): e1000365. PMC 2628735. PMID 19197348. doi:10.1371/journal.pgen.1000365.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMC 528928. PMID 15489334. doi:10.1101/gr.2596504.
- Kamboh MI, Aston CE, Hamman RF (2000). "DNA sequence variation in human apolipoprotein C4 gene and its effect on plasma lipid profile". Atherosclerosis 152 (1): 193–201. PMID 10996355. doi:10.1016/S0021-9150(99)00459-1.
- Klos KL, Sing CF, Boerwinkle E, et al. (2006). "Consistent effects of genes involved in reverse cholesterol transport on plasma lipid and apolipoprotein levels in CARDIA participants". Arterioscler. Thromb. Vasc. Biol. 26 (8): 1828–36. PMID 16763159. doi:10.1161/01.ATV.0000231523.19199.45.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899.
- Kotite L, Zhang LH, Yu Z, et al. (2003). "Human apoC-IV: isolation, characterization, and immunochemical quantification in plasma and plasma lipoproteins". J. Lipid Res. 44 (7): 1387–94. PMID 12700345. doi:10.1194/jlr.M300087-JLR200.
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