Interleucina 17A
Identificadores | |
Símbolo | IL17A |
Símbolos alt. | IL17, CTLA8 |
Entrez | 3605 |
HUGO | 5981 |
OMIM | |
RefSeq | NP_002181 |
UniProt | Q16552 |
Outros datos |
A interleucina 17A (IL-17A ou IL17A) é unha proteína reguladora do tipo das citocinas que nos humanos etá codificada no xene IL17A do cromosoma 6.[1][2] Foi a primeira interleucina descuberta da familia da IL-17, polo que tamén se lle deu inicialmente o símbolo IL17, e en ratos CTLA8.
A proteína codificada por este xene é unha citocina proinflamatoria producida por células T activadas. Esta citocina regula a actividade do NF-kappaB e as proteína quinases activadas por mitóxeno. Esta citocina pode estimular a expresión de IL6 e da ciclooxixenase 2 (PTGS2/COX-2), e tamén potencia a produción de óxido nítrico (NO). Altos niveis desta citocina están asociados con varias doenzas inflamatorias crónicas como a artrite reumatoide, psoríase e esclerose múltiple.[2]
Notas
editar- ↑ Rouvier E, Luciani MF, Mattei MG, Denizot F, Golstein P (Jul 1993). "CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene". J Immunol 150 (12): 5445–56. PMID 8390535.
- ↑ 2,0 2,1 "Entrez Gene: IL17A interleukin 17A".
Véxase tamén
editarOutros artigos
editarBibliografía
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- Andoh A, Shimada M, Bamba S; et al. (2002). "Extracellular signal-regulated kinases 1 and 2 participate in interleukin-17 plus tumor necrosis factor-alpha-induced stabilization of interleukin-6 mRNA in human pancreatic myofibroblasts.". Biochim. Biophys. Acta 1591 (1-3): 69–74. PMID 12183057. doi:10.1016/S0167-4889(02)00250-1.
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- Este artigo incorpora textos en dominio público da Biblioteca Nacional de Medicina dos Estados Unidos.