Peróxido orgánico: Diferenzas entre revisións
Contido eliminado Contido engadido
Liña 56:
Clivaxe de [[cetona]]s e alcohois no [[rearranxo de Kornblum–DeLaMare]]
Algúns peróxidos son [[fármaco]]s cuxa acción está baseada na formación de radicais en lugares desexados do organismo. Por exemplo, a [[artemisinina]] e os seus derivados, como o [[artesunato]], posúen a acción máis rápida de todos os fármacos actuais contra a [[malaria]] por ''[[Plasmodium falciparum]]''.<ref>{{cite journal |author=White NJ |title=Assessment of the pharmacodynamic properties of antimalarial drugs in vivo |journal=Antimicrob. Agents Chemother. |volume=41 |issue=7 |pages=1413–22 |year=1997|pmid=9210658 |pmc=163932|doi=10.1128/AAC.41.7.1413 }}</ref>
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Several analytical methods are used for qualitative and quantitative determination of peroxides.<ref>{{cite journal|last1=Légrádi|first1=L.|last2=Légrádi|first2=J.|title=Detection of peroxides, hydroperoxides and peracids|journal=Microchimica Acta|volume=58|pages=119–122|year=1970|doi=10.1007/BF01218105}}</ref> A simple qualitative detection of peroxides is carried out with the [[iodine test|iodine-starch reaction]].<ref>{{cite journal|last1=Lea|first1=C. H.|title=The Effect of Light on the Oxidation of Fats|journal=Proceedings of the Royal Society B: Biological Sciences|volume=108|pages=175–189|year=1931|doi=10.1098/rspb.1931.0030|issue=756}}</ref> Here peroxides, hydroperoxides or peracids oxidize the added [[potassium iodide]] into [[iodine]], which reacts with [[starch]] producing a deep-blue color. Commercial paper indicators using this reaction are available. This method is also suitable for quantitative evaluation, but it can not distinguish between different types of peroxide compounds. Discoloration of various [[indigo dye]]s in presence of peroxides is used instead for this purpose.<ref>Veibel, S. ''Analytik organischer Verbindungen'', Akademie-Verlag, Berlin, 1960, p. 262</ref> For example, the loss of blue color in leuco-[[methylene blue]] is selective for hydrogen peroxide.<ref>{{cite journal|last1=Eiss|first1=M. I.|last2=Giesecke|first2=Paul|title=Colorimetric Determination of Organic Peroxides|journal=Analytical Chemistry|volume=31|pages=1558|year=1959|doi=10.1021/ac60153a038|issue=9}}</ref>
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