Trombospondina 1: Diferenzas entre revisións

 

O dominio carboxilo terminal da TSP1 crese que media a unión celular e únese a outro importante receptor para a TSP1, o IAP (ou [[CD47]]).<ref name="pmid1644809">{{cite journal | vauthors = Kosfeld MD, Frazier WA | title = Identification of active peptide sequences in the carboxyl-terminal cell binding domain of human thrombospondin-1 | journal = The Journal of Biological Chemistry | volume = 267 | issue = 23 | pages = 16230–6 | date = Aug 1992 | pmid = 1644809 | doi = | url = http://www.jbc.org/cgi/content/abstract/267/23/16230 }}</ref> Ese receptor é considerado necesario para as respostas das células vasculares mediadas pola TSP1 estimuladas polo [[factor de relaxación derivado do endotelio|óxido nítrico]] e a sinalización por [[GMP cíclico]].<ref name="pmid16835222">{{cite journal | vauthors = Isenberg JS, Ridnour LA, Dimitry J, Frazier WA, Wink DA, Roberts DD | title = CD47 is necessary for inhibition of nitric oxide-stimulated vascular cell responses by thrombospondin-1 | journal = The Journal of Biological Chemistry | volume = 281 | issue = 36 | pages = 26069–80 | date = Sep 2006 | pmid = 16835222 | doi = 10.1074/jbc.M605040200 }}</ref> Varios dominios e receptores da TSP1 teñen actividades proadhesivas e [[quimiotaxe|quimiotácticas]] para as células cancerosas, o que suxire que esta molécula pode ter un efecto directo sobre a bioloxía do cancro independentemente das súas propiedades antianxioxénicas.<ref name="pmid10196234">{{cite journal | vauthors = Chandrasekaran S, Guo NH, Rodrigues RG, Kaiser J, Roberts DD | title = Pro-adhesive and chemotactic activities of thrombospondin-1 for breast carcinoma cells are mediated by alpha3beta1 integrin and regulated by insulin-like growth factor-1 and CD98 | journal = The Journal of Biological Chemistry | volume = 274 | issue = 16 | pages = 11408–16 | date = Apr 1999 | pmid = 10196234 | doi = 10.1074/jbc.274.16.11408 | url = http://www.jbc.org/cgi/pmidlookup?view=long&pmid=10196234 }}</ref><ref name="pmid3680388">{{cite journal | vauthors = Taraboletti G, Roberts DD, Liotta LA | title = Thrombospondin-induced tumor cell migration: haptotaxis and chemotaxis are mediated by different molecular domains | journal = The Journal of Cell Biology | volume = 105 | issue = 5 | pages = 2409–15 | date = Nov 1987 | pmid = 3680388 | pmc = 2114831 | doi = 10.1083/jcb.105.5.2409 }}</ref>

 

== Tratamento do cancro ==