Diferenzas entre revisións de «Factor de crecemento de hepatocitos»

 
== Interaccións ==
O factor de crecemento de hepatocitos presenta [[interaccións proteína-proteína|interaccións]] co produto proteico do oncoxene c-Met, identificado como receptor de HGF ([[c-Met|HGFR]]).<ref name="pmid1846706"/><ref name="pmid8380735">{{cite journal | vauthors = Comoglio PM | title = Structure, biosynthesis and biochemical properties of the HGF receptor in normal and malignant cells | journal = Exs | volume = 65 | issue = | pages = 131–65 | year = 1993 | pmid = 8380735 | doi = }}</ref><ref name="pmid1655405">{{cite journal | vauthors = Naldini L, Weidner KM, Vigna E, Gaudino G, Bardelli A, Ponzetto C, Narsimhan RP, Hartmann G, Zarnegar R, Michalopoulos GK | title = Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor | journal = The EMBO Journal | volume = 10 | issue = 10 | pages = 2867–78 | date = October 1991 | pmid = 1655405 | pmc = 452997 | doi = }}</ref> Tanto a sobreexpresión da proteína do receptor Met/HGFR coma a activación [[sinalización autócrina|autócrina]] de Met/HGFR pola expresión simultánea do [[ligando]] factor de crecemento de hepatocitos foron implicadas na [[oncoxénese]].<ref>{{cite journal | vauthors = Johnson M, Koukoulis G, Kochhar K, Kubo C, Nakamura T, Iyer A | title = Selective tumorigenesis in non-parenchymal liver epithelial cell lines by hepatocyte growth factor transfection | journal = Cancer Letters | volume = 96 | issue = 1 | pages = 37–48 | date = September 1995 | pmid = 7553606 | doi = 10.1016/0304-3835(95)03915-j }}</ref><ref>{{cite journal | vauthors = Kochhar KS, Johnson ME, Volpert O, Iyer AP | title = Evidence for autocrine basis of transformation in NIH-3T3 cells transfected with met/HGF receptor gene | journal = Growth Factors | volume = 12 | issue = 4 | pages = 303–13 | date = 1995 | pmid = 8930021 | doi = 10.3109/08977199509028968 }}</ref>
O factor de crecemento de hepatocitos interacciona cos [[glicosaminoglicano]]s sufatados [[heparán sulfato]] e [[dermatán sulfato]].<ref name="ReferenceA">{{cite journal | vauthors = Lyon M, Deakin JA, Gallagher JT | title = The mode of action of heparan and dermatan sulfates in the regulation of hepatocyte growth factor/scatter factor | journal = The Journal of Biological Chemistry | volume = 277 | issue = 2 | pages = 1040–6 | date = January 2002 | pmid = 11689562 | doi = 10.1074/jbc.M107506200 }}</ref><ref>{{cite journal | vauthors = Lyon M, Deakin JA, Rahmoune H, Fernig DG, Nakamura T, Gallagher JT | title = Hepatocyte growth factor/scatter factor binds with high affinity to dermatan sulfate | journal = J Biol Chem | volume = 273 | issue = 1 | pages = 271–8. | date = Jan 1998 | PMID = 9417075 | doi = 10.1074/jbc.273.1.271 | url = http://www.jbc.org/content/273/1/271.long}}</ref> A interacción co heparán sulfato permite que o factor de crecemento de hepatocitos forme un complexo con c-Met que pode [[transdución de sinais|transducir sinais]] intracelulares que orixinarán a [[división celular]] e a [[migración celular]].<ref name="ReferenceA"/><ref>{{cite journal | vauthors = Sergeant N, Lyon M, Rudland PS, Fernig DG, Delehedde M | title = Stimulation of DNA synthesis and cell proliferation of human mammary myoepithelial-like cells by hepatocyte growth factor/scatter factor depends on heparan sulfate proteoglycans and sustained phosphorylation of mitogen-activated protein kinases p42/44 | journal = The Journal of Biological Chemistry | volume = 275 | issue = 22 | pages = 17094–9 | date = June 2000 | pmid = 10747885 | doi = 10.1074/jbc.M000237200 }}</ref>
 
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