O PDGF wasfoi oneun ofdos the firstprimeiros [[growth factor de crecemento|factores de crecemento]]scharacterized,que foi caracterizado.<ref>{{cite journal |vauthors=Paul D, Lipton A, Klinger I | title = Serum factor requirements of normal and simian virus 40-transformed 3T3 mouse fibroplasts | journal = Proc Natl Acad Sci U S A | volume = 68 | issue = 3 | pages = 645–52 | year = 1971 | pmid = 5276775 | pmc = 389008 | doi = 10.1073/pnas.68.3.645 }}</ref> andA hasprimeira led to an understanding of the mechanism of many growth factor [[biochemical signaling|signaling pathways]].{{Citation needed|date=April 2007}}Theproteína firstnegativa engineereddominante dominantde negativeenxeñaría proteinfoi wasdeseñada designedpara toinhibir inhibito PDGF <ref>{{cite journal|last1=Mercola|first1=M|last2=Deininger|first2=P L|last3=Shamah|first3=S M|last4=Porter|first4=J|last5=Wang|first5=C Y|last6=Stiles|first6=C D|title=Dominant-negative mutants of a platelet-derived growth factor gene.|journal=Genes & Development|date=1 December 1990|volume=4|issue=12b|pages=2333–2341|doi=10.1101/gad.4.12b.2333}}</ref>
