Diferenzas entre revisións de «Receptor da vitamina D»

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O '''receptor da vitamina D''' ('''VDR''') ou '''receptor do calcitriol''', tamén chamado '''NR1I1''' (receptor nuclear familia 1, grupo I, membro 1), é un membro da familia dodos [[receptor nuclear|receptores nucleares]] de [[factor de transcrición|factores de transcrición]].<ref name="pmid17132852">{{cite journal | vauthors = Moore DD, Kato S, Xie W, Mangelsdorf DJ, Schmidt DR, Xiao R, Kliewer SA | title = International Union of Pharmacology. LXII. The NR1H and NR1I receptors: constitutive androstane receptor, pregnene X receptor, farnesoid X receptor alpha, farnesoid X receptor beta, liver X receptor alpha, liver X receptor beta, and vitamin D receptor | journal = Pharmacol. Rev. | volume = 58 | issue = 4 | pages = 742–59 | date = December 2006 | pmid = 17132852 | doi = 10.1124/pr.58.4.6 }}</ref> O [[calcitriol]], é a forma activa da [[vitamina D]], e únese ao VDR, que despois forma un [[heterodímero]] co [[receptor X retinoide]]. Este despois únese aos [[elemento de resposta a hormonas|elementos de resposta a hormonas]] do [[ADN]], o que resulta na [[expresión xénica|expresión]] ou [[transrepresión]] de produtos xénicos específicos. O VDR non só regula as respostas transcricionais senón que tamén implica mecanismos postranscricionais dirixidos por [[microARN]].<ref name="pmid23362149">{{cite journal | vauthors = Lisse TS, Chun RF, Rieger S, Adams JS, Hewison M | title = Vitamin D activation of functionally distinct regulatory miRNAs in primary human osteoblasts | journal = J Bone Miner Res. | volume = 28 | issue = 6 | pages = 1478-14788 | date = June 2013 | pmid = 23362149 | doi = 10.1002/jbmr.1882 }}</ref> En humanos, o receptor da vitamina D está codificado polo xene ''VDR'' situado no [[cromosoma 12 humano]].<ref name="pmid1662663">{{cite journal | vauthors = Szpirer J, Szpirer C, Riviere M, Levan G, Marynen P, Cassiman JJ, Wiese R, DeLuca HF | title = The Sp1 transcription factor gene (SP1) and the 1,25-dihydroxyvitamin D3 receptor gene (VDR) are colocalized on human chromosome arm 12q and rat chromosome 7 | journal = Genomics | volume = 11 | issue = 1 | pages = 168–73 | date = September 1991 | pmid = 1662663 | doi = 10.1016/0888-7543(91)90114-T | url = http://linkinghub.elsevier.com/retrieve/pii/0888-7543(91)90114-T }}</ref>
 
Os [[glicocorticoide]]s diminúen a expresión do VDR, que se expresa na maioría dos tecidos do corpo e regula o transporte [[intestinal]] de [[calcio]], [[ferro]] e outros minerais.<ref name="pmid21182397">{{cite journal | vauthors = Fleet JC, Schoch RD | title = Molecular Mechanisms for Regulation of Intestinal Calcium Absorption by Vitamin D and Other Factors | journal = Crit Rev Clin Lab Sci | volume = 47 | issue = 4 | pages = 181–195 | date = August 2010 | pmid = 21182397 | doi = 10.3109/10408363.2010.536429 | url = http://informahealthcare.com/doi/abs/10.3109/10408363.2010.536429 | pmc=3235806}}</ref>
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