Diferenzas entre revisións de «Ogt»

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A '''''O''<sup>6</sup>-alquilguanina ADN alqultransferase II''' (''O''<sup>6</sup> AGT II), anteriormente chamada '''''O''<sup>6</sup> guanina transferase''' ('''ogt'''), é unha [[proteína]] bacteriana que intervén na [[reparación do ADN]] xunto coa proteína [[Ada (proteína)|Ada]] (tamén chamada ''O''<sup>6</sup> AGT I).<ref name="Friedberg">{{citeCita booklibro | title = DNA Repair and Mutagenesis | edition = 2 | last1 = Friedberg | first1 = Errol | first2 = Graham C. | last2 = Walker | first3 = Wolfram | last3 = Siede | first4 = Richard D. | last4 = Wood | first5 = Roger A. | last5 = Schultz | first6 = Tom | last6 = Ellenberger | name-list-format = vanc | author-link4 = Richard D. Wood | year = 2006 | publisher=ASM Press | location = Washington, DC | isbn = 1-55581-319-4 | OCLC = 59360087 | pages = }}</ref>
 
Igual que a AGT I, a AGT II é responsable da eliminación de grupos [[alquilo]] da ''O''<sup>6</sup>-alquilguanina, a ''O''<sup>4</sup>-alquiltimina e o alquilfosfotriéster no esqueleto de azucre-fosfato do ADN.<ref name="Friedberg"/> A AGT II mostra unha gran preferencia pola ''O''<sup>4</sup>-alquiltimina sobre a ''O''<sup>6</sup>-alquilguanina e o alquilfosfotriéster.<ref name="Friedberg"/><ref name="Sassanfar">{{cite journal | vauthors = Sassanfar M, Dosanjh MK, Essigmann JM, Samson L | title = Relative efficiencies of the bacterial, yeast, and human DNA methyltransferases for the repair of O6-methylguanine and O4-methylthymine. Suggestive evidence for O4-methylthymine repair by eukaryotic methyltransferases | journal = The Journal of Biological Chemistry | volume = 266 | issue = 5 | pages = 2767–71 | date = Feb 1991 | pmid = 1993655 }}</ref>
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