CD45: Diferenzas entre revisións

O '''CD45''' ([[cluster de diferenciación|''cluster'' de diferenciación]]), chamado inicialmente '''antíxeno común leucocitario''', e chamado agora '''PTPRC''' (''Protein Tyrosine Phospatase, Receptor type, C'', proteína tirosina fosfatase, tipo receptor, C) é un [[encima]] que se encontra na superficie de células [[hematopoético|hematopoéticas]], que nos humanos está codificado no [[xene]] PTPRC do [[cromosoma 1]].<ref name="pmid2169617">{{citeCita journalpublicación periódica | author = Kaplan R, Morse B, Huebner K, ''et al'' | title = Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 87 | issue = 18 | pages = 7000–4 | year = 1990 | month = September | pmid = 2169617 | pmc = 54670 | doi = 10.1073/pnas.87.18.7000| url = http://www.pnas.org/cgi/pmidlookup?view=long&pmid=2169617 | issn = }}</ref> <ref name="entrez">{{cite web | title = Entrez Gene: PTPRC protein tyrosine phosphatase, receptor type, C| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5788| accessdate = }}</ref>

A PTPRC interacciona con [[LYN]],<ref name="pmid7516335">{{citeCita journalpublicación periódica | author = Brown VK, Ogle EW, Burkhardt AL, Rowley RB, Bolen JB, Justement LB | title = Multiple components of the B cell antigen receptor complex associate with the protein tyrosine phosphatase, CD45 | journal = J. Biol. Chem. | volume = 269 | issue = 25 | pages = 17238–44 | year = 1994 | month = June | pmid = 7516335 | doi = }}</ref> [[Lck]],<ref name="pmid8473339">{{citeCita journalpublicación periódica | author = Koretzky GA, Kohmetscher M, Ross S | title = CD45-associated kinase activity requires lck but not T cell receptor expression in the Jurkat T cell line | journal = J. Biol. Chem. | volume = 268 | issue = 12 | pages = 8958–64 | year = 1993 | month = April | pmid = 8473339 | doi = }}</ref><ref name="pmid8576115">{{citeCita journalpublicación periódica | author = Ng DH, Watts JD, Aebersold R, Johnson P | title = Demonstration of a direct interaction between p56lck and the cytoplasmic domain of CD45 in vitro | journal = J. Biol. Chem. | volume = 271 | issue = 3 | pages = 1295–300 | year = 1996 | month = January | pmid = 8576115 | doi = 10.1074/jbc.271.3.1295}}</ref> [[SKAP1]]<ref name="pmid11909961">{{citeCita journalpublicación periódica | author = Wu L, Fu J, Shen SH | title = SKAP55 coupled with CD45 positively regulates T-cell receptor-mediated gene transcription | journal = Mol. Cell. Biol. | volume = 22 | issue = 8 | pages = 2673–86 | year = 2002 | month = April | pmid = 11909961 | pmc = 133720 | doi = 10.1128/MCB.22.8.2673-2686.2002 }}</ref> e [[GANAB]].<ref name="pmid9148925">{{citeCita journalpublicación periódica | author = Arendt CW, Ostergaard HL | title = Identification of the CD45-associated 116-kDa and 80-kDa proteins as the alpha- and beta-subunits of alpha-glucosidase II | journal = J. Biol. Chem. | volume = 272 | issue = 20 | pages = 13117–25 | year = 1997 | month = May | pmid = 9148925 | doi = 10.1074/jbc.272.20.13117 }}</ref><ref name="pmid10921916">{{citeCita journalpublicación periódica | author = Baldwin TA, Gogela-Spehar M, Ostergaard HL | title = Specific isoforms of the resident endoplasmic reticulum protein glucosidase II associate with the CD45 protein-tyrosine phosphatase via a lectin-like interaction | journal = J. Biol. Chem. | volume = 275 | issue = 41 | pages = 32071–6 | year = 2000 | month = October | pmid = 10921916 | doi = 10.1074/jbc.M003088200 }}</ref><ref name="pmid11564800">{{citeCita journalpublicación periódica | author = Baldwin TA, Ostergaard HL | title = Developmentally regulated changes in glucosidase II association with, and carbohydrate content of, the protein tyrosine phosphatase CD45 | journal = J. Immunol. | volume = 167 | issue = 7 | pages = 3829–35 | year = 2001 | month = October | pmid = 11564800 | doi = }}</ref>

Viuse recentemente que o CD45 interacciona tamén coa proteína UL11 do citomegalovirus humano ([[HCMV]]). Esta interacción orixina unha parálise funcional temporal das células T.<ref name="pmid22174689">{{citeCita journalpublicación periódica | author = Gabaev I, Steinbrück L, Pokoyski C, Pich A, Stanton RJ, Schwinzer R, Schulz TF, Jacobs R, Messerle M, Kay-Fedorov PC | title = The human cytomegalovirus UL11 protein interacts with the receptor tyrosine phosphatase CD45, resulting in functional paralysis of T cells | journal = PLoS Pathog. | volume = 7 | issue = 12 | pages = e1002432 | year = 2011 | month = December | pmid = 22174689 | pmc = 3234252 | doi = 10.1371/journal.ppat.1002432 }}</ref>

* {{citeCita journalpublicación periódica | author=Tchilian EZ, Beverley PC |title=CD45 in memory and disease. |journal=Arch. Immunol. Ther. Exp. (Warsz.) |volume=50 |issue= 2 |pages= 85–93 |year= 2002 |pmid= 12022705 |doi= }}

* {{citeCita journalpublicación periódica | author=Ishikawa H, Tsuyama N, Abroun S, ''et al.'' |title=Interleukin-6, CD45 and the src-kinases in myeloma cell proliferation. |journal=Leuk. Lymphoma |volume=44 |issue= 9 |pages= 1477–81 |year= 2004 |pmid= 14565647 |doi=10.1080/1042819031000097339 }}

* {{citeCita journalpublicación periódica | author=Stanton T, Boxall S, Bennett A, ''et al.'' |title=CD45 variant alleles: possibly increased frequency of a novel exon 4 CD45 polymorphism in HIV seropositive Ugandans. |journal=Immunogenetics |volume=56 |issue= 2 |pages= 107–10 |year= 2004 |pmid= 15057492 |doi= 10.1007/s00251-004-0668-z }}

* {{citeCita journalpublicación periódica | author=Huntington ND, Tarlinton DM |title=CD45: direct and indirect government of immune regulation. |journal=Immunol. Lett. |volume=94 |issue= 3 |pages= 167–74 |year= 2005 |pmid= 15275963 |doi= 10.1016/j.imlet.2004.05.011 }}