Interaccións proteína-proteína: Diferenzas entre revisións

LargeA scaleidentificación identificationa ofgrande PPIsescala generatedde hundredsIPPs ofxerou thousandscentos interactions,de whichmiles werede collecteddatos togetherde ininteraccións, specializedque [[biologicalforon databases]]recollidas thaten arebases continuouslyde updateddatos inbiolóxicas orderespecializadas, toque provideestán completeáctualizándose decote para proporcionar [[interactomesinteractoma]]s completos. TheA firstprimeira ofdestas thesebases databasesde wasdatos thefoi a [[Database of Interacting Proteins|Database of Interacting Proteins (DIP)]].<ref name="pmid10592249">{{cite pmid|10592249|noedit}}</ref> SinceDesde thatese timemomento, theo numbernúmero ofde publicbases databasesde hasdatos beenpúblicas increasingfoise incrementando. DatabasesAs canbases bede subdivideddatos intopoden primarydividirse databasesen bases de datos primarias, meta-databasesbases de datos, ande bases de datos predictionde databasespredición.<ref name=Rivas>{{cite journal|last=De Las Rivas|first=J.|coauthors=Fontanillo, C.|title=Protein-protein interactions essentials: key concepts to building and analyzing interactome networks.|journal=PLoS computational biology|year=2010|volume=6|issue=6|pages=e1000807|pmid=20589078}}</ref>

* '''PrimaryBases databasesde datos primarias'''. collectRecollen informationinformación aboutsobre publishedIPPs PPIspublicadas provende toexistencia existcomprobada viapor small-scalemedio orde large-scalemétodos experimentais a grande ou experimentalpequena methodsescala. ExamplesExemplos: [[Database of Interacting Proteins|DIP]], [[Biomolecular Interaction Network Database]] (BIND), Biological General Repository for Interaction Datasets (BioGRID), Human Protein Reference Database (HPRD), IntAct Molecular Interaction Database, Molecular Interactions Database (MINT), MIPS Protein Interaction Resource on Yeast (MIPS-MPact), ande MIPS Mammalian Protein-Protein Interaction Database (MIPS-MPPI).<ref name="Rivas" />

* '''Meta-databasesbases de datos'''. normallyNormalmente resultorixínanse fromda theintegración integrationde ofinformación primaryde databasesbases informationde datos primarias, butpero canpoden alsotamén collectrecoller somealgúns originaldatos dataorixinais. ExamplesExemplos: Agile Protein Interaction DataAnalyzer (APID), The Microbial Protein Interaction Database (MPID8), ande a plataforma Protein Interaction Network Analysis (PINA) platform.<ref name="Rivas" />

* '''PredictionBases databasesde datos de predición'''. includeInclúen manymoitas PPIsIPPs thatpreditas areusando predicteddiversas using several techniques (main article)técnicas. ExamplesExemplos: Michigan Molecular Interactions (MiMI), Human Protein-Protein Interaction Prediction Database (PIPs), Online Predicted Human Interaction Database (OPHID), Known and Predicted Protein-Protein Interactions (STRING), ande Unified Human Interactome (UniHI).<ref name="Rivas" />