Aconitase: Diferenzas entre revisións

Finally, aconitase is thought to be associated with [[diabetes]].<ref name=pmid3884379/><ref name = "type 1 source"/> Although the exact connection is still being determined, multiple theories exist.<ref name=pmid3884379>{{cite journal |pages=173–6 |doi=10.1016/0014-5793(85)80979-0 |title=Alterations in mitochondrial aconitase activity and respiration, and in concentration of citrate in some organs of mice with experimental or genetic diabetes |year=1985 |last1=Boquist |first1=L. |last2=Ericsson |first2=I. |last3=Lorentzon |first3=R. |last4=Nelson |first4=L. |journal=FEBS Letters |volume=183 |pmid=3884379 |issue=1}}</ref><ref name= "type 1 source"/> In a study of organs from mice with alloxan diabetes (experimentally induced diabetes<ref name="alloxan def">"Alloxan Diabetes - Medical Definition," Stedman's Medical Dictionary, 2006 Lippincott Williams & Wilkins, http://www.medilexicon.com/medicaldictionary.php?t=24313</ref>) and genetic diabetes, lower aconitase activity was found to decrease the rates of metabolic reactions involving citrate, pyruvate, and malate.<ref name=pmid3884379/> In addition, citrate concentration was observed to be unusually high.<ref name=pmid3884379/> Since these abnormal data were found in diabetic mice, the study concluded that low aconitase activity is likely correlated with genetic and alloxan diabetes.<ref name=pmid3884379/> Another theory is that, in diabetic hearts, accelerated phosphorylation of heart aconitase by protein kinase C causes aconitase to speed up the final step of its reverse reaction relative to its forward reaction.<ref name = "type 1 source"/> That is, it converts isocitrate back to ''cis''-aconitate more rapidly than usual, but the forward reaction proceeds at the usual rate.<ref name = "type 1 source"/> This imbalance may contribute to disrupted metabolism in diabetics.<ref name = "type 1 source">{{cite journal |pages=919–32 |doi=10.1007/s00018-009-8696-3 |title=Regulation of mitochondrial aconitase by phosphorylation in diabetic rat heart |year=2009 |last1=Lin |first1=G. |last2=Brownsey |first2=R. W. |last3=MacLeod |first3=K. M. |journal=Cellular and Molecular Life Sciences |volume=66 |issue=5 |pmid=19153662}}</ref>

 

 

{|

| Name = aconitase 1, soluble

| caption =

| width =

| HGNCid = 117

| AltSymbols = IREB1

| EntrezGene = 48

| PDB =

| ECnumber = 4.2.1.3

| LocusSupplementaryData =

}}

| Name = aconitase 2, mitochondrial

| caption =

| width =

| HGNCid = 118

| AltSymbols = ACONM

| EntrezGene = 50

| PDB =

| ECnumber = 4.2.1.3

| LocusSupplementaryData =

}}