Ácido erúcico: Diferenzas entre revisións

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Liña 21:
O ácido erúcico prodúcese por elongación do [[ácido oleico]] por medio do oleoíl-[[coencima A]] e [[malonil-CoA]].<ref name=Bao>{{cite journal | author = Bao Xiaoming, Pollard Mike, Ohlrogge John | year = 1998 | title = The Biosynthesis of Erucic Acid in Developing Embryos of Brassica rapa | url = | journal = Plant Physiol | volume = 118 | issue = | pages = 183–190 | pmid = 9733537 }}</ref> O ácido erúcico é degradado orixinando ácidos graxos de cadeas máis curtas no fígado humano por acción do [[encima]] [[acilo de cadea longa-CoA deshidroxenase]].
 
== Efectos sobesobre a saúde ==
Os efectos do ácido erúcico consumido cos aceites comestibles na saúde humana é controvertido. Porén, non se documentaron efectos negativos sobre a saúde en humanos.<ref name=fsa/>
The effects of erucic acid from edible oils on human health are controversial. However no negative health effects have ever been documented in humans.<ref name=fsa/>
 
O [[Mustardaceite oilde mostaza]] wasfoi onceantes consideredconsiderado unsuitableinadecuado forpoara humano consumptionconsumo inhumano thena UnitedUnión StatesEuropea, [[Canada]],Estados andUnidos thee [[EuropeanCanadá Union]]debido dueao toseu thealto highcontido contenten ofácido erucic aciderúcico. ThisIsto isdebeuse becausea ofque earlynos studiesprimeiros inestudos ratsfeitos en ratas parecía ser prexudicial. SubsequentEstudos studiesposteriores onen ratsratas havemostraron shownque thatestes theyanimais areteñen lessunha ablemenor tocapacidade digestde vegetabledixerir fatsos (whetheraceites theyvexetais contain(conteñsan erucicácido aciderúcico orou notnon) thanque humansos andhumanos e os pigsporcos.<ref>{{cite journal|author=Hulan HW, Kramer JK, Mahadevan S, Sauer FD |title=Relationship between erucic acid and myocardial changes in male rats|journal=Lipids|volume=11|issue=1|pages=9–15 |year=1976|month=January|pmid=1250074|doi=10.1007/BF02532578|url=}}</ref><ref>{{cite journal|author=Kramer JK, Farnworth ER, Thompson BK, Corner AH, Trenholm HL|title=Reduction of myocardial necrosis in male albino rats by manipulation of dietary fatty acid levels|journal=Lipids|volume=17|issue=5 |pages=372–82|year=1982|month=May|pmid=7098776|doi=10.1007/BF02535197|url=}}</ref><ref>{{cite journal |author=de Wildt DJ, Speijers GJ|title=Influence of dietary rapeseed oil and erucic acid upon myocardial performance and hemodynamics in rats |journal=Toxicol. Appl. Pharmacol.|volume=74 |issue=1|pages=99–108|year=1984|month=June|pmid=6729825|doi=10.1016/0041-008X(84)90275-8|url=http://linkinghub.elsevier.com/retrieve/pii/0041-008X(84)90275-8}}</ref> Chariton ''et al.'' suggestsindicou thatque innas ratsratas: “Inefficient“A activationactivación ofineficiente erucicdo acidácido toerúcico a erucylerucil-CoA ande aun lowbaixo levelnivel ofde activityactividade ofda [[triglyceridetriglicérido lipase]] ande enzymesencimas ofda betaoxidation[[beta-oxidación]] forpra erucico acidácido probablyerúcico contributecontribúen toprobablemente theá accumulationacumulación ande retentionretención ofde cardiaclípidos lipidcardíacos.”<ref name=Charlton>{{cite journal |author=Charlton KM, Corner AH, Davey K, Kramer JK, Mahadevan S, Sauer FD |title=Cardiac lesions in rats fed rapeseed oils |journal=Can. J. Comp. Med. |volume=39 |issue=3 |pages=261–9 |year=1975 |month=July |pmid=1170010 |pmc=1277456 |doi= |url=}}</ref> BeforeAntes thisde processque wasse fullychegase understooda itcomprender ledplenamente toeste theproceso, beliefpensábase thatque erucico acidácido anderúcico mustarde oilo wereaceite bothde highlymostaza toxiceran totamén humansmoi tóxicos para os humanos. TheA highalta percentageporcentaxe ofde erucicácido aciderúcico inque [[mustardten oil]]o hasaceite ledde tomostaza thefixo latterque beingeste bannedaceite forfose foodprohibido usepara inusos thealimenticios [[Europeanna Union]]Unión andEuropea e otheroutros countriespaíses.
 
EpidemiologicalOs studiesestudops suggestepidemiolóxicos thatindican que, inen regionsrexións whereonde mustardaúnda oilse isusa stillo usedaceite inde amostaza dun traditionalmodo mannertradicional, mustardeste oilaceite maypode affordproporcionar somecerta protectionprotección againstcontra cardiovascularas enfermidades diseasescardiovasculares. InNeste thissentido sense“tradicional” “traditional”significa means thatque (a) the oilo isaceite usedutilízase freshfresco; ande (b) vegetableas fatsgraxas countvexetais onlysupoñen as aunha porcentaxe smallpequena percentageda ofinxesta thecalórica total. caloricNon intake.se Whethersabe thisse effecteste isefecto duese todebe theá naturenatureza ofdo erucicácido aciderúcico ''perque se''fai toque makeas theplaquetas blood plateletsse lessaglomeren stickymenos, orou toá thepresenza presencedunha ofalta aporcentaxe reasonablyde high[[ácido percentagealfa-linolénico|ácido of [[α-linolenic acidlinolénico]], or toou a combinationunha ofcombinación propertiesde ofpropiedades freshdo unrefinedaceite oil,fresco isnon as yet uncertainrefinado. Care needs to be taken with such epidemiological studies to exclude the possibility of early deaths from other causes skewing the results. The fact that early asymptomatic coronary disease is readily detectable post mortem and is absent in the mustard oil cohorts tends to add weight to the hypothesis that mustard oil is protective.<ref>{{cite journal |author=Rastogi T, Reddy KS, Vaz M, ''et al.'' |title=Diet and risk of ischemic heart disease in India |journal=Am. J. Clin. Nutr. |volume=79 |issue=4 |pages=582–92 |year=2004 |month=April |pmid=15051601 |doi= |url=http://www.ajcn.org/cgi/content/full/79/4/582 }}</ref>
 
AUnha four-to-onemestura mixturede ofcatro erucica acidun andde [[oleicácido acid]]erúcico constitutese ácido oleico constitúe o chamado [[Lorenzo'saceite oilde Lorenzo]]; anun tratamento experimental treatmentpara foro thetrastorno rareneurobiolóxico neurobiologyraro disorder [[adrenoleukodystrophyadrenoleucodistrofia]]. Nos [[Thrombocytopenia]]pacientes hastratados beencon seenaceite inde patientsLorenzo treatedobservouse with Lorenzo’s oil[[trombocitopenia]], probablyprobablemente relacionada relatedco toseu itscontido erucicen acidácido contenterúcico.<ref name="pmid7847331">{{cite journal | author = Crowther MA, Barr RD, Kelton J, Whelan D, Greenwald M | title = Profound thrombocytopenia complicating dietary erucic acid therapy for adrenoleukodystrophy | journal = [[American Journal of Hematology]] | volume = 48 | issue = 2 | pages = 132–3 | year = 1995 | month = February | pmid = 7847331 | doi = | url = | issn = }}</ref>
 
HoweverPorén, fornalgúns thepaíses reasonsnon givense above, it is notaconsella advisableque foras nursingnais motherslactantes ore babiesmeniños totomen eatalimentos foodque containingconteñan erucicácido aciderúcico.<ref name=fsa>Food Standards Australia New Zealand (June 2003) [http://www.foodstandards.gov.au/_srcfiles/Erucic%20acid%20monograph.pdf Erucic acid in food] : ''A Toxicological Review and Risk Assessment .'' Technical report series No. 21; Page 4 paragraph 1; ISBN 0-642-34526-0, ISSN 1448-3017</ref><ref>{{cite web
|url=http://www.food.gov.uk/news/newsarchive/2004/sep/erucic
|title=Food Standards Agency - Agency issues warning on erucic acid