MacrolidesOs aremacrólidos son inhibidores da [[proteintradución synthesis(proteínas)|síntese inhibitorproteica]]s.Thenas [[mechanismbacterias, ofe action]]pénsase ofque macrolidesfan isisto [[enzymeimpedindo inhibitor|inhibition]] ofque bacteriala [[protein biosynthesispeptidiltransferase]], and they are thought to do this by preventing [[peptidyltransferaseribosoma]] fromenlace addingo thegrupo peptidylpeptidil attached(proteína toen crecemento) unido ao [[Transfer RNA|tRNAARNt]] to theao nextseguinte aminoaminoácido acid<ref name=pharmamotion>[http://pharmamotion.com.ar/protein-synthesis-inhibitors-macrolides-mechanism-of-action-animation-classification-of-agents/ Protein synthesis inhibitors: macrolides mechanism of action animation. Classification of agents] Pharmamotion. Author: Gary Kaiser. The Community College of Baltimore County. Retrieved on July 31, 2009</ref> (similarly to [[chloramphenicol]]){{Citation needed|date=October 2009}} as well as inhibiting [[ribosomal translocation]].<ref name=pharmamotion/> AnotherOutro potentialmecanismo mechanismpotencial isé prematurea dissociationdisociación ofprematura thedo [[peptidylpeptidil-tRNAARNt]] from thedo ribosomeribosoma.<ref name=lovmar>[http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WK7-490R2TT-C&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=19d53b7156b390f5ed0a09eb156c18ea The Mechanism of Action of Macrolides, Lincosamides and Streptogramin B Reveals the Nascent Peptide Exit Path in the Ribosome] Martin Lovmar and Måns Ehrenberg</ref>
Macrolide antibiotics do so by binding reversibly to the P site on the subunit [[50S]] of the bacterial [[ribosome]]. This action is mainly bacteriostatic, but can also be bactericidal in high concentrations. Macrolides tend to accumulate within [[leukocyte]]s, and are, therefore, transported into the site of infection.{{Citation needed|date=September 2010}}
