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==Unión aos ligandos==
===Interferón-γ===
TheA cellrexión surfacede receptor bindingunión regionreceptora ofdo [[Interferoninterferón-γ]] overlapsda withsuperficie thecelular HSsolápase bindingcoa regionrexión de unión do heparán sulfato, nearpreto thedo protein'sextremo C-terminal da proteína. BindingCando ofse HSune blockso theheparán receptorsulfato, bindingbloquea siteo andsitio asde aunión resultdese receptor e como resultado, proteinos complexos proteína-HSheparán complexessulfato areson inactiveinactivos.<ref>{{cite journal | author=Sadir, R. | title=The heparan sulphate binding sequence of interferon-γ increased the on rate of the interferon-γ / interferon-γ receptor complex formation | journal=J. Biol. Chem. | year=1998 | volume=273 | pages=10919–10925 | url=http://www.jbc.org/cgi/content/abstract/273/18/10919 | doi=10.1074/jbc.273.18.10919 | pmid=9556569 | issue=18 | display-authors=1 | last2=Forest | first2=E | last3=Lortat-Jacob | first3=H}}</ref>
Foron tamén estudadas as propiedades de unión ao heparán sulfato das seguintes proteínas:
The HS-binding properties of a number of other proteins are also being studied:
* [[AntithrombinAntitrombina III]]
* [[Factores de crecemento dos fibroblastos]]
* [[Fibroblast Growth Factors]]
* [[Factor de crecemento do hepatocito]]
* [[Hepatocyte Growth Factor]]
* [[InterleukinInterleucina-8]]
* [[Factor de crecemento endotelial vascular]]
* [[Vascular Endothelial Growth Factor]]
* ''[[Wnt/Wingless]]''
* [[EndostatinEndostatina]]
==Notas==
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