Transxelina

PDB 1ujo
Transxelina
Identificadores
Símbolo	TAGLN
Símbolos alt.	SM22; SMCC; TAGLN1; WS3-10
Entrez	6876
OMIM	600818
RefSeq	NP_001001522
UniProt	Q01995
Outros datos
Locus	Cr. 11 117.07 – 117.08 Mb

A transxelina (TAGLN) é unha proteína que nos humanos está codificada polo xene TAGLN do cromosoma 11.

A proteína transxelina é unha proteína xelificante/creadora de pontes cruzadas coa actina sensible aos cambios de forma celulares e ás transformacións (como as producidas nas células mesenquimais por virus ou por cambiar a condicións de cultivo non adherentes), que se encontra nos fibroblastos e no músculo liso. A súa expresión está regulada á baixa en moitas liñas celulares, e está regulación á baixa pode ser un marcador sensible e temperán para o comezo da transformación. Ao feito de que produza xeles e sexa sensible ás transformacións débese o seu nome (trans-xel-ina). O papel funcional desta proteína non está claro. Neste xene atopáronse dous transcritos variantes que codifican a mesma proteína. A transxelina ten un peso molecular de 22 kDa e ten unha similitude estrutural coa calponina.

Véxase tamén

Outros artigos

• Repeticións de calponina

Bibliografía

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