Wikipedia

Neuropilina 2

A neuropilina 2 ou neuropilina-2 é unha proteína que nos humanos está codificada no xene NRP2 do cromosoma 2.[1][2] É un dos dous tipos de neuropilinas humanas, o outro é a NRP1.

NRP2
Estruturas dispoñibles
PDBBuscar ortólogos: PDBe, RCSB
Identificadores
SímbolosNRP2 (HGNC: 8005) NRP2, NP2, NPN2, PRO2714, VEGF165R2, neuropilina 2
Identificadores
externos
LocusCr. 2 q33.3
Padrón de expresión de ARNm
Máis información
Ortólogos
Especies
Humano Rato
Entrez
8828 18187
Ensembl
Véxase HS Véxase MM
UniProt
O60462 O35375
RefSeq
(ARNm)
NM_003872 NM_001077403
RefSeq
(proteína) NCBI
NP_003863 NP_001070871
Localización (UCSC)
Cr. 2:
205.68 – 205.8 Mb 		Cr. 1:
62.74 – 62.86 Mb
PubMed (Busca)
8828


18187

Este xene codifica un membro da familia da neuropilina de proteínas receptoras. A NRP2 exprésana unha ampla variedade de tipos celulares. Esta proteína transmembrana únese a SEMA3C, SEMA3F, VEGF-A, VEGF-C, VEGF-D, TGFβ, integrinas e ANGPTL4 para promover vías de sinalización augas abaixo. Consecuentemente, a NRP2 xoga un papel no desenvolvemento cardiovascular, guía de axóns, tumoroxénese, inflamación e doenzas cardiovasculares.[3][4][5][6] Identificáronse múltiples variantes de transcritos deste xene que codifican distintas isoformas.[7]

Notas editar

  1. ↑ Soker S, Takashima S, Miao HQ, Neufeld G, Klagsbrun M (marzo de 1998). "Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor". Cell 92 (6): 735–45. PMID 9529250. doi:10.1016/S0092-8674(00)81402-6. 
  2. ↑ Chen H, Chédotal A, He Z, Goodman CS, Tessier-Lavigne M (setembro de 1997). "Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III". Neuron 19 (3): 547–59. PMID 9331348. doi:10.1016/S0896-6273(00)80371-2. 
  3. ↑ Harman, Jennifer L.; Sayers, Jacob; Chapman, Chey; Pellet-Many, Caroline (2020-07-21). "Emerging Roles for Neuropilin-2 in Cardiovascular Disease". International Journal of Molecular Sciences 21 (14): 5154. PMC 7404143. PMID 32708258. doi:10.3390/ijms21145154. 
  4. ↑ Kofler N, Simons M (maio de 2016). "The expanding role of neuropilin: regulation of transforming growth factor-β and platelet-derived growth factor signaling in the vasculature". Current Opinion in Hematology 23 (3): 260–7. PMC 4957701. PMID 26849476. doi:10.1097/MOH.0000000000000233. 
  5. ↑ Peng K, Bai Y, Zhu Q, Hu B, Xu Y (febreiro de 2019). "Targeting VEGF-neuropilin interactions: a promising antitumor strategy". Drug Discovery Today 24 (2): 656–664. PMID 30315890. doi:10.1016/j.drudis.2018.10.004. 
  6. ↑ Kitsukawa T, Shimizu M, Sanbo M, Hirata T, Taniguchi M, Bekku Y, Yagi T, Fujisawa H (novembro de 1997). "Neuropilin-semaphorin III/D-mediated chemorepulsive signals play a crucial role in peripheral nerve projection in mice". Neuron 19 (5): 995–1005. PMID 9390514. doi:10.1016/s0896-6273(00)80392-x. 
  7. ↑ "Entrez Gene: NRP2 neuropilin 2". 

Véxase tamén editar

Bibliografía editar

  • Neufeld G, Cohen T, Gengrinovitch S, Poltorak Z (xaneiro de 1999). "Vascular endothelial growth factor (VEGF) and its receptors". FASEB Journal 13 (1): 9–22. PMID 9872925. doi:10.1096/fasebj.13.1.9. 
  • Kolodkin AL, Levengood DV, Rowe EG, Tai YT, Giger RJ, Ginty DD (agosto de 1997). "Neuropilin is a semaphorin III receptor". Cell 90 (4): 753–62. PMID 9288754. doi:10.1016/S0092-8674(00)80535-8. 
  • Giger RJ, Urquhart ER, Gillespie SK, Levengood DV, Ginty DD, Kolodkin AL (novembro de 1998). "Neuropilin-2 is a receptor for semaphorin IV: insight into the structural basis of receptor function and specificity". Neuron 21 (5): 1079–92. PMID 9856463. doi:10.1016/S0896-6273(00)80625-X. 
  • Chen H, He Z, Bagri A, Tessier-Lavigne M (decembro de 1998). "Semaphorin-neuropilin interactions underlying sympathetic axon responses to class III semaphorins". Neuron 21 (6): 1283–90. PMID 9883722. doi:10.1016/S0896-6273(00)80648-0. 
  • Takahashi T, Nakamura F, Jin Z, Kalb RG, Strittmatter SM (outubro de 1998). "Semaphorins A and E act as antagonists of neuropilin-1 and agonists of neuropilin-2 receptors". Nature Neuroscience 1 (6): 487–93. PMID 10196546. doi:10.1038/2203. 
  • Rossignol M, Beggs AH, Pierce EA, Klagsbrun M (maio de 1999). "Human neuropilin-1 and neuropilin-2 map to 10p12 and 2q34, respectively". Genomics 57 (3): 459–60. PMID 10329017. doi:10.1006/geno.1999.5790. 
  • Tamagnone L, Artigiani S, Chen H, He Z, Ming GI, Song H, et al. (outubro de 1999). "Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates". Cell 99 (1): 71–80. PMID 10520995. doi:10.1016/S0092-8674(00)80063-X. 
  • Gluzman-Poltorak Z, Cohen T, Herzog Y, Neufeld G (xuño de 2000). "Neuropilin-2 is a receptor for the vascular endothelial growth factor (VEGF) forms VEGF-145 and VEGF-165 [corrected]". The Journal of Biological Chemistry 275 (24): 18040–5. PMID 10748121. doi:10.1074/jbc.M909259199. 
  • Handa A, Tokunaga T, Tsuchida T, Lee YH, Kijima H, Yamazaki H, et al. (agosto de 2000). "Neuropilin-2 expression affects the increased vascularization and is a prognostic factor in osteosarcoma". International Journal of Oncology 17 (2): 291–5. PMID 10891538. doi:10.3892/ijo.17.2.291. 
  • Rossignol M, Gagnon ML, Klagsbrun M (decembro de 2000). "Genomic organization of human neuropilin-1 and neuropilin-2 genes: identification and distribution of splice variants and soluble isoforms". Genomics 70 (2): 211–22. PMID 11112349. doi:10.1006/geno.2000.6381. 
  • Gluzman-Poltorak Z, Cohen T, Shibuya M, Neufeld G (xuño de 2001). "Vascular endothelial growth factor receptor-1 and neuropilin-2 form complexes". The Journal of Biological Chemistry 276 (22): 18688–94. PMID 11278319. doi:10.1074/jbc.M006909200. 
  • Cohen T, Gluzman-Poltorak Z, Brodzky A, Meytal V, Sabo E, Misselevich I, et al. (xuño de 2001). "Neuroendocrine cells along the digestive tract express neuropilin-2". Biochemical and Biophysical Research Communications 284 (2): 395–403. PMID 11394892. doi:10.1006/bbrc.2001.4958. 
  • Herzog Y, Kalcheim C, Kahane N, Reshef R, Neufeld G (novembro de 2001). "Differential expression of neuropilin-1 and neuropilin-2 in arteries and veins". Mechanisms of Development 109 (1): 115–9. PMID 11677062. doi:10.1016/S0925-4773(01)00518-4. 
  • Oh H, Takagi H, Otani A, Koyama S, Kemmochi S, Uemura A, Honda Y (xaneiro de 2002). "Selective induction of neuropilin-1 by vascular endothelial growth factor (VEGF): a mechanism contributing to VEGF-induced angiogenesis". Proceedings of the National Academy of Sciences of the United States of America 99 (1): 383–8. PMC 117569. PMID 11756651. doi:10.1073/pnas.012074399. 
  • Fakhari M, Pullirsch D, Abraham D, Paya K, Hofbauer R, Holzfeind P, et al. (xaneiro de 2002). "Selective upregulation of vascular endothelial growth factor receptors neuropilin-1 and -2 in human neuroblastoma". Cancer 94 (1): 258–63. PMID 11815985. doi:10.1002/cncr.10177. 
  • Cohen T, Herzog Y, Brodzky A, Greenson JK, Eldar S, Gluzman-Poltorak Z, et al. (setembro de 2002). "Neuropilin-2 is a novel marker expressed in pancreatic islet cells and endocrine pancreatic tumours". The Journal of Pathology 198 (1): 77–82. PMID 12210066. doi:10.1002/path.1179. 
  • Kawakami T, Tokunaga T, Hatanaka H, Kijima H, Yamazaki H, Abe Y, et al. (novembro de 2002). "Neuropilin 1 and neuropilin 2 co-expression is significantly correlated with increased vascularity and poor prognosis in nonsmall cell lung carcinoma". Cancer 95 (10): 2196–201. PMID 12412174. doi:10.1002/cncr.10936. 
 
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