Annalisa Pastore, King’s College, London e Università di Pavia
Iron sulfur cluster: from the crucible of life to a rare disease
Abstract:
Iron sulfur clusters, non amino acidic groups attached to proteins to assist them in their functions, are required to sustain fundamental cellular pathways. Being ubiquitous and evolutionarily ancient, they are thought to be the first response to the problem of storing iron and sulfur, two essential but toxic elements, in a bioavailable form. Iron sulfur clusters are at the very centre of life and have also been suggested to be present in the Last Universal Common Ancestor (LUCA). Cluster formation requires complex machines constituted by an intricate network of proteins and electron transfer pathways which we are only recently starting to understand. Modifications of any of the components of these machines result in disease. In my seminar I shall review our current knowledge and discuss our contributions to the field.
recoñecemento – Debe indicar a debida atribución de autoría, fornecer unha ligazón á licenza e indicar se se realizaron cambios. Pode facer isto de calquera forma razoable, mais non nunha forma que indique que quen posúe a licenza apoia ou subscribe o seu uso da obra.
https://creativecommons.org/licenses/by/3.0CC BY 3.0 Creative Commons Attribution 3.0 truetrue
Engada unha explicación dunha liña do representa este ficheiro
Annalisa Pastore, professor of Chemistry and Molecular Biology at King’s College, London speaks on iron sulfur clusters at the Scuola Normale Superiore di Pisa in 2017
Este ficheiro contén información adicional, probablemente engadida pola cámara dixital ou polo escáner usado para crear ou dixitalizar a imaxe. Se o ficheiro orixinal foi modificado, poida que algúns detalles non se reflictan no ficheiro modificado.