[[Ficheiro:Histopathology of siderophage in chronic pulmonary congestion.jpg|thumbminiatura|Histopatoloxía dun caso de conxestión pulmonar, que mostraintersticios con deposición de hemosiderina (frecha negra), [[edema]] e engrosamento do [[coláxeno]]. Os [[alvéolo pulmonar|alvéolos]] conteñen un [[siderófago]] (frecha branca, caracterizado polo seu groso [[pigmrnto biolóxico|pigmento]] castaño, que é lixeiramente refráctil).]]
[[imageFicheiro:hemosiderin1.jpg|thumbminiatura|HemosiderinRil imagevisto ofao amicrosocopio. kidneyAs viewedáreas undermarróns ason microscopede hemosiderina. The brown areas represent hemosiderin]]
A '''Hemosiderinhemosiderina''' oré '''haemosiderin'''un iscomplexo anprotico para o almacenamento de [[ironferro]]-storagecomplexque thatestá iscomposto composedde of[[ferritina]] partiallyparcialmente digesteddixerida ferritine and lysosomes[[lisosoma]]s. TheA degradación breakdowndo ofgrupo [[hemehemo]] givesdá riselugar toa [[biliverdinbiliverdina]] ande ironferro.<ref name="Definition, Staining, Function and Treatment 2019">{{cite web | title=Hemosiderin | website=Definition, Staining, Function and Treatment | date=2019-05-04 | url=https://mddk.com/hemosiderin.html | access-date=2019-05-04}}</ref><ref name="Kalakonda John 2018">{{cite journal | last1=Kalakonda | first1=Aditya | last2=John | first2=Savio | title=Physiology, Bilirubin | website=NCBI Bookshelf | date=2018-10-27 | pmid=29261920 | url=https://www.ncbi.nlm.nih.gov/books/NBK470290/ | access-date=2019-05-04}}</ref> TheEntón bodyo thencorpo trapsatrapa theo releasedfero ironliberado ande storesalmacénao itcomo as hemosiderinhemosiderina innos tissuestecidos.<ref name="Litwack 2018 pp. 591–643">{{cite book | last=Litwack | first=Gerald | title=Human Biochemistry | chapter=Micronutrients (Metals and Iodine) | publisher=Elsevier | year=2018 | isbn=978-0-12-383864-3 | doi=10.1016/b978-0-12-383864-3.00019-3 | pages=591–643}}</ref> HemosiderinA ishemosiderina alsoxérase generatedtamén fromnas thevías abnormalmetabólicas metabolicanormais pathwayda of [[ferritin]]ferritina.<ref name="Litwack 2018 pp. 591–643"/>
It is only found within cells (as opposed to circulating in blood) and appears to be a complex of [[ferritin]], denatured ferritin and other material.<ref>{{cite journal|last1=Richter|first1=Goetz|title=A Study of Hemosiderosis with Aid of Electron Microscopy|journal=The Journal of Experimental Medicine|date=1 August 1957|volume=106|issue=2|pages=203–218|doi=10.1084/jem.106.2.203 |pmid=13449232|pmc=2136742}}</ref><ref>{{cite journal|last1=Fischbach|first1=FA|last2=Gregory|first2=DW|last3=Harrison|first3=PM|last4=Hoy|first4=TG|last5=Williams|first5=JM|title=On the structure of hemosiderin and its relationship to ferritin.|journal=Journal of Ultrastructure Research|date=December 1971|volume=37|issue=5|pages=495–503|doi=10.1016/S0022-5320(71)80020-5|pmid=5136270}}</ref> The iron within deposits of hemosiderin is very poorly available to supply iron when needed. Hemosiderin can be identified histologically with ''[[Perls' Prussian blue]] stain''; iron in hemosiderin turns blue to black when exposed to potassium ferrocyanide.<ref>{{Cite book|title=Robbins & Cotran Pathologic Basis of Disease, 9th Edition|last=Kumar, Abbas, Aster|first=Vinay, Abul K., Jon C.|publisher=Elsevier|year=2015|isbn=978-1-4557-2613-4|pages=650}}</ref> In normal animals, hemosiderin deposits are small and commonly inapparent without special stains. Excessive accumulation of hemosiderin is usually detected within cells of the mononuclear phagocyte system (MPS) or occasionally within epithelial cells of liver and kidney.▼
▲ItSó isse onlyatopa founddentro withindas cellscélulas (ase opposednon tocirculando circulatinglibre inpolo blood[[sangue]]) ande appearsparece toser beun acomplexo complexde of [[ferritin]]ferritina, denaturedferitina ferritindesnaturalizada ande otheroutros materialmateriais.<ref>{{cite journal|last1=Richter|first1=Goetz|title=A Study of Hemosiderosis with Aid of Electron Microscopy|journal=The Journal of Experimental Medicine|date=1 August 1957|volume=106|issue=2|pages=203–218|doi=10.1084/jem.106.2.203 |pmid=13449232|pmc=2136742}}</ref><ref>{{cite journal| last1=Fischbach |first1=FA |last2=Gregory |first2=DW |last3=Harrison |first3=PM|last4=Hoy |first4=TG| last5=Williams |first5=JM|title=On the structure of hemosiderin and its relationship to ferritin.|journal=Journal of Ultrastructure Research|date=December 1971|volume=37|issue=5|pages=495–503|doi=10.1016/S0022-5320(71)80020-5|pmid=5136270}}</ref> TheO ironferro withindos depositsdepósitos ofde hemosiderinhemosiderina isestá verypouco poorlydispoñible availablepara toa supplysubministración ironde whenfero neededcando esta se necesita. A Hemosiderinhemosiderina canpode beidentificarse identifiedhistoloxicamente histologicallycoa withtinguidura de ''[[Perls'azul Prussiande bluePrusia de Perls]] stain''; irono inferro hemosiderinda turnshemosiderina bluetoma toun blackton whende exposedazul toa negro canso se expón a potassiumferrocianuro ferrocyanidepotásico.<ref>{{Cite book|title=Robbins & Cotran Pathologic Basis of Disease, 9th Edition|last=Kumar, Abbas, Aster|first=Vinay, Abul K., Jon C.|publisher=Elsevier|year=2015|isbn=978-1-4557-2613-4|pages=650}}</ref> InNos normalanimais animals,normais hemosiderinos depositsdepósitos arede smallhemosiderina andson commonlypequenos inapparente withoutpouco specialaparentes stainsse non se aplican tinguiduras especiais. ExcessiveXeralmente accumulationdetéctanse ofacumulacións hemosiderinexcesivas isde usuallyhemosiderina detecteddentro withindas cellscélulas ofdo thesistema fagocítico mononuclear phagocyteou systemocasionalmente (MPS)dentro orde occasionallycélulas withinepiteliais epithelialdo cellsfígado of liver ande kidneyril.
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Several disease processes result in deposition of larger amounts of hemosiderin in tissues; although these deposits often cause no symptoms, they can lead to [[lesions|organ damage]].
