PhagolysosomesOs functionfagolisosomas byfuncionan reducingreducindo theo [[pH]] ofdo theirseu internalambiente environmentinterno, thusque makingasí themse acidicfai máis ácido. ThisIstro servesserve ascomo aun defensemecanismo mechanismde againstdedfensa microbescontra andmicrobioes othere harmfuloutros parasitesparasitos andperigosos alsoe providestamén aproporciona suitableun mediummedio foraxeitado para a degradativeactividade enzymeencimática activitydegradativa.<ref>{{Cite journal|last=Levitz|first=S. M.|last2=Nong|first2=S. H.|last3=Seetoo|first3=K. F.|last4=Harrison|first4=T. S.|last5=Speizer|first5=R. A.|last6=Simons|first6=E. R.|date=1999-02-01|title=Cryptococcus neoformans resides in an acidic phagolysosome of human macrophages|journal=Infection and Immunity|volume=67|issue=2|pages=885–890|issn=0019-9567|pmc=96400|pmid=9916104}}</ref>
MicrobesOs aremicrobios destroyedson withindestruídos phagolysosomesnos byfagolisosomas apor combinationunha ofcombinación [[oxidation|oxidative]]de andprocesos oxidativos e non-oxidativeprocessesoxidativos. TheOs oxidativeprocesos processoxidativos alsotamén knownse ascoñecen como [[respiratoryexplosión burstrespiratoria]] includese theinclén a produción "non- [[mitochondrion|mitochondrialmitocondria]]l" production ofde [[reactiveespecies reactivas oxygendo speciesoxíxeno]].<ref>{{Cite journal|last=Urban|first=Constantin F.|last2=Lourido|first2=Sebastian|last3=Zychlinsky|first3=Arturo|date=2006-11-01|title=How do microbes evade neutrophil killing?|journal=Cellular Microbiology|volume=8|issue=11|pages=1687–1696|doi=10.1111/j.1462-5822.2006.00792.x|issn=1462-5814|pmid=16939535}}</ref>
ByAo loweringdiminuír o pH ande concentrationsas ofconcentracións sourcesde offontes de [[carboncarbono]] ande [[nitrogennitróxeno]], phagolysomesos inhibitfagolisosomas growthinhiben ofo crecemento de [[fungi|fungos]]. AnUn exampleexemplo isé thea inhibitioninhibición ofdo crecemento de [[hypha|hyphaehifa]]s inen ''[[Candida albicans]]''.<ref>{{Cite journal|last=Erwig|first=Lars P.|last2=Gow|first2=Neil A. R.|date=2016-03-01|title=Interactions of fungal pathogens with phagocytes|journal=Nature Reviews. Microbiology|volume=14|issue=3|pages=163–176|doi=10.1038/nrmicro.2015.21|issn=1740-1534|pmid=26853116}}</ref>
In humanNos [[neutrophilneutrófilo]]s,thehumanos os phagolysosomesfagolisosomas destroydestrúen pathogenspatóxenos alsoao byproduciren producingtamén [[hypochlorousácido acidhipocloroso]].<ref>{{Cite journal|last=Painter|first=Richard G.|last2=Wang|first2=Guoshun|date=2006-05-01|title=Direct measurement of free chloride concentrations in the phagolysosomes of human neutrophils|journal=Analytical Chemistry|volume=78|issue=9|pages=3133–3137|doi=10.1021/ac0521706|issn=0003-2700|pmid=16643004}}</ref>
