Polyomaviridae: Diferenzas entre revisións
Contido eliminado Contido engadido
Liña 65:
=== Agnoproteína ===
<!--▼
The [[agnoprotein]] is a small multifunctional phospho-protein found in the late coding part of the genome of some polyomaviruses, most notably [[BK virus]], [[JC virus]], and [[SV40]]. It is essential for proliferation in the viruses that express it and is thought to be involved in regulating the viral life cycle, particularly replication and viral exit from the host cell, but the exact mechanisms are unclear.<ref name=Sariyer2011>{{cite journal | vauthors = Sariyer IK, Saribas AS, White MK, Safak M | title = Infection by agnoprotein-negative mutants of polyomavirus JC and SV40 results in the release of virions that are mostly deficient in DNA content | journal = Virology Journal | volume = 8 | pages = 255 | date = May 2011 | pmid = 21609431 | pmc = 3127838 | doi = 10.1186/1743-422X-8-255 }}</ref><ref name="saribas_2016">{{cite journal | vauthors = Saribas AS, Coric P, Hamazaspyan A, Davis W, Axman R, White MK, Abou-Gharbia M, Childers W, Condra JH, Bouaziz S, Safak M | title = Emerging From the Unknown: Structural and Functional Features of Agnoprotein of Polyomaviruses | journal = Journal of Cellular Physiology | volume = 231 | issue = 10 | pages = 2115–27 | date = October 2016 | pmid = 26831433 | doi = 10.1002/jcp.25329 | pmc = 5217748 }}</ref>▼
▲
== Taxonomía ==
▲<!--
The polyomaviruses are members of group I (dsDNA viruses). The classification of polyomaviruses has been the subject of several proposed revisions as new members of the group are discovered. Formerly, polyomaviruses and [[papillomavirus]]es, which share many structural features but have very different genomic organizations, were classified together in the now-obsolete family ''[[Papovaviridae]]''.<ref name=ICTVTaxononmy>{{cite web|title=ICTV Taxonomy Website|url=https://talk.ictvonline.org/taxonomy }}</ref> (The name ''Papovaviridae'' derived from three abbreviations: Pa for ''Papillomavirus'', Po for ''Polyomavirus'', and Va for "vacuolating.")<ref name="IARC">{{cite journal|last1=International Agency for Research on Cancer|title=IARC Working Group on the Evaluation of Carcinogenic Risk to Humans. Malaria and Some Polyomaviruses (SV40, BK, JC, and Merkel Cell Viruses).|journal=IARC Monographs on the Evaluation of Carcinogenic Risks to Humans|date=2013|volume=104|url=https://www.ncbi.nlm.nih.gov/books/NBK294248/}}</ref> The polyomaviruses were divided into three major [[clade]]s (that is, genetically-related groups): the SV40 clade, the avian clade, and the murine polyomavirus clade.<ref>{{cite journal | vauthors = Pérez-Losada M, Christensen RG, McClellan DA, Adams BJ, Viscidi RP, Demma JC, Crandall KA | title = Comparing phylogenetic codivergence between polyomaviruses and their hosts | journal = Journal of Virology | volume = 80 | issue = 12 | pages = 5663–9 | date = June 2006 | pmid = 16731904 | pmc = 1472594 | doi = 10.1128/JVI.00056-06 }}</ref> A subsequent proposed reclassification by the [[International Committee on Taxonomy of Viruses]] (ICTV) recommended dividing the family of Polyomaviridae into three genera:<ref name="Johne2011">{{cite journal | vauthors = Johne R, Buck CB, Allander T, Atwood WJ, Garcea RL, Imperiale MJ, Major EO, Ramqvist T, Norkin LC | title = Taxonomical developments in the family Polyomaviridae | journal = Archives of Virology | volume = 156 | issue = 9 | pages = 1627–34 | date = September 2011 | pmid = 21562881 | pmc = 3815707 | doi = 10.1007/s00705-011-1008-x }}</ref>
*Genus ''Orthopolyomavirus'' (type species [[SV40]])
| |||