Creatina quinase: Diferenzas entre revisións

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== Probas de laboratorio ==
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CK is often determined routinely in a [[medical laboratory]]. It used to be determined specifically in patients with [[chest pain]] but this test has been replaced by [[troponin]]. Normal values at rest are usually between 60 and 174 IU/[[litre|L]],<ref name = "Armstrong_2008" /> where one unit is [[enzyme activity]], more specifically the amount of enzyme that will catalyze 1 μmol of substrate per minute under specified conditions (temperature, pH, substrate concentrations and activators.<ref name = "Bishop_2004" />) This test is not specific for the ''type'' of CK that is elevated.
 
A CK é medida con frecuencia nos laboratorios médicos. Adoita determinanrse especificamente en pacientes de [[dor torácica]], pero esta proba foi substituída pola da [[troponina]]. Os valores normais en repouso están xeralmente entre 60 e 174 IU/[[litro|L]],<ref name = "Armstrong_2008" /> onde unha unidade é a [[actividade encimática]], máis especificamente a cantidade de encimas que catalizará 1 μmol de substrato por minuto baixo condicións específicas (temperatura, [[pH]], concentracións de substrato e activadores.<ref name = "Bishop_2004" />) Esta proba non é específica para o ''tipo'' de CK que está elevado.
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Creatine kinase in the blood may be high in health and disease. Exercise increases the outflow of creatine kinase to the blood stream for up to a week, and this is the most common cause of high CK in blood.<ref name=pmid21063205>{{cite journal | vauthors = Johnsen SH, Lilleng H, Wilsgaard T, Bekkelund SI | title = Creatine kinase activity and blood pressure in a normal population: the Tromsø study | journal = Journal of Hypertension | volume = 29 | issue = 1 | pages = 36–42 | date = January 2011 | pmid = 21063205 | doi = 10.1097/HJH.0b013e32834068e0 }}</ref> Furthermore, high CK in the blood may be related to high intracellular CK such as in persons of African descent.<ref name=pmid22438879>{{cite journal | vauthors = Brewster LM, Coronel CM, Sluiter W, Clark JF, van Montfrans GA | title = Ethnic differences in tissue creatine kinase activity: an observational study | journal = PLOS One | volume = 7 | issue = 3 | pages = e32471 | date = 2012-03-16 | pmid = 22438879 | pmc = 3306319 | doi = 10.1371/journal.pone.0032471 | editor-first = Valdur | editor-last = Saks | name-list-format = vanc }}</ref>