Creatina quinase: Diferenzas entre revisións
Contido eliminado Contido engadido
Sen resumo de edición |
Sen resumo de edición |
||
Liña 12:
A '''creatina quinase''' ('''CK'''), tamén chamada '''creatina fosfoquinase''' ('''CPK''') ou '''fosfocreatina quinase''', é un [[encima]] ({{EC number|2.7.3.2}}) expresado en varios [[tecido (bioloxía)|trcidos]] e tipos celulares. A CK cataliza a conversión de [[creatina]] e utiliza [[adenosín trifosfato]] (ATP) para crear [[fosfocreatina]] (PCr) e [[adenosín difosfato]] (ADP). Esta reacción encimática da CK é reversible, polo que pode xerarse ATP a partir de PCr e ADP.
<!--▼
In tissues and cells that consume ATP rapidly, especially [[skeletal muscle]], but also brain, [[photoreceptor cell]]s of the [[retina]], [[hair cell]]s of the [[inner ear]], [[spermatozoa]] and [[smooth muscle]], PCr serves as an energy reservoir for the rapid buffering and regeneration of ATP ''in situ'', as well as for intracellular energy transport by the PCr shuttle or circuit.<ref name=pmid1731757>{{cite journal | vauthors = Wallimann T, Wyss M, Brdiczka D, Nicolay K, Eppenberger HM | title = Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: the 'phosphocreatine circuit' for cellular energy homeostasis | journal = The Biochemical Journal | volume = 281 ( Pt 1) | issue = 1 | pages = 21–40 | date = January 1992 | pmid = 1731757 | pmc = 1130636 | doi = 10.1042/bj2810021 }}</ref> Thus creatine [[kinase]] is an important enzyme in such tissues.<ref name=pmid7808454>{{cite journal | vauthors = Wallimann T, Hemmer W | title = Creatine kinase in non-muscle tissues and cells | journal = Molecular and Cellular Biochemistry | volume = 133-134 | issue = 1 | pages = 193–220 | year = 1994 | pmid = 7808454 | doi = 10.1007/BF01267955 | eissn = 1573-4919 }}</ref>▼
▲
▲<!--
Clinically, creatine kinase is assayed in blood tests as a marker of damage of CK-rich tissue such as in [[myocardial infarction]] (heart attack), [[rhabdomyolysis]] (severe muscle breakdown), [[muscular dystrophy]], autoimmune [[Myositis|myositides]], and [[acute kidney injury]].<ref>{{cite journal | vauthors = Moghadam-Kia S, Oddis CV, Aggarwal R | title = Approach to asymptomatic creatine kinase elevation | journal = Cleveland Clinic Journal of Medicine | volume = 83 | issue = 1 | pages = 37–42 | date = January 2016 | pmid = 26760521 | pmc = 4871266 | doi = 10.3949/ccjm.83a.14120 }}</ref>
| |||