Canle iónica regulada por voltaxe: Diferenzas entre revisións
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=== Canles de protóns (H<sup>+</sup>) ===
[[Voltage-gated proton channel]]s carry currents mediated by [[hydrogen ion]]s in the form of [[hydronium]], and are activated by depolarization in a [[pH]]-dependent manner. They function to remove acid from cells.<ref>{{Citation|last1=Cherny|first1=V.V.|last2=Markin|first2=V.S.|last3=DeCoursey|first3=T.E.|publication-date=June 1995|title=The voltage-activated hydrogen ion conductance in rat alveolar epithelial cells is determined by the pH gradient|periodical=Journal of General Physiology|volume=105|issue=6|pages=861–896|url=http://www.jgp.org/cgi/reprint/105/6/861.pdf|accessdate=2008-07-14|doi=10.1085/jgp.105.6.861|year=1995}}</ref><ref>{{Citation|last=DeCoursey|first=T.E.|publication-date=2003|title=Voltage-gated proton channels and other proton transfer pathways|periodical=Physiological Reviews|volume=83|issue=2|pages=475–579|url=http://physrev.physiology.org/cgi/content/full/83/2/475|doi=10.1152/physrev.00028.2002|oclc=205658168|accessdate=2008-07-14|pmid=12663866|year=2003}}</ref><ref>{{Cite journal|url=http://www.nature.com/nsmb/journal/v17/n7/abs/nsmb.1826.html|title=An aqueous H<sup>+</sup> permeation pathway in the voltage-gated proton channel Hv1|first1=I. Scott|last1=Ramsey|first2=Younes|last2=Mokrab|first3=Ingrid|last3=Carvacho|first4=Zara A.|last4=Sands|first5=Mark S.P.|last5=Sansom|first6=David E.|last6=Clapham|journal=Nature Structural & Molecular Biology|volume=17|issue=7|pages=869–875|date=2010|doi=10.1038/nsmb.1826|pmid=20543828|pmc=4035905}}</ref>
== Filoxenética ==▼
[[Phylogenetics|Phylogenetic]] studies of proteins expressed in bacteria revealed the existence of a [[protein superfamily|superfamily]] of voltage-gated sodium channels.<ref>{{cite journal | vauthors = Koishi R, Xu H, Ren D, Navarro B, Spiller BW, Shi Q, Clapham DE | title = A superfamily of voltage-gated sodium channels in bacteria | journal = The Journal of Biological Chemistry | volume = 279 | issue = 10 | pages = 9532–8 | date = March 2004 | pmid = 14665618 | doi = 10.1074/jbc.M313100200 }}</ref> Subsequent studies have shown that a variety of other ion channels and [[Ion transporter|transporters]] are phylogenetically related to the voltage-gated ion channels, including [[Inward-rectifier potassium ion channel|inwardly rectifying K<sup>+</sup> channels]], [[Ryanodine-Inositol 1,4,5-triphosphate receptor calcium channels|ryanodine-inositol 1,4,5-triphosphate receptor Ca<sup>2+</sup> channels]], [[Transient receptor potential calcium channel family|transient receptor potential Ca<sup>2+</sup> channels]], [[Polycystin cation channel family|polycystin cation channels]], [[Glutamate-gated ion channel family|glutamate-gated ion channels]], [[calcium-dependent chloride channel]]s, [[Monovalent cation:proton antiporter-1|monovalent cation:proton antiporters, type 1]], and [[Potassium transporter family|potassium transporters]].<ref>{{Cite journal|title=Phylogeny as a guide to structure and function of membrane transport proteins|first1=Abraham B.|last1=Chang|first2=Ron|last2=Lin|first3=W. Keith|last3=Studley|first4=Can V.|last4=Tran|first5=Milton H., Jr.|last5=Saier|journal=Mol Membr Biol|date=2004|volume=21|issue=3|pages=171–181|doi=10.1080/09687680410001720830|pmid=15204625}}</ref>▼
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▲== Filoxenética ==
▲Os estudos [[
== Notas ==
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