Diferenzas entre revisións de «Factor X»

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{{Non confundir|Factor X (programa de televisión)}}
{{proteína
| Nome = F10
| image = Protein F10 PDB 1c5m.png
| width =
| caption = {{PDB|1c5m}}
| Símbolo = F10
| AltSymbols =FX, FXA, factor de coagulación X
| ATC_prefix=
| ATC_suffix=
| ATC_supplemental=
| CAS_number=
| CAS_supplemental=
| DrugBank=
| EntrezGene =2159
| HGNCid =
| OMIM = 613872
| PDB =
| RefSeq = NP_000495
| UniProt = P00742
| ECnumber =
| Cromosoma = 13
| Brazo = q
| Banda = 34
| LocusSupplementaryData = :(113.12 – 113.15 Mb)
}}
:''Non se debe confundir co [[protoporfirina IX|factor X]] de crecemento para o cultivo da bacteria ''Haemophilus influenzae'' correspondente á protroporfirina IX ou hemina.''
O '''factor X''' (factor dez) de coagulación, tamén chamado '''factor de Stuart–Prower''', é un [[encima]] ({{EC number|3.4.21.6}}) da [[coagulación do sangue|fervenza de coagulación]] do [[sangue]]. É unha [[Serina protease|serina endopeptidase]] (protease do grupo S1, [[clan PA]]). O factor X é sintetizado no [[fígado]] e require [[vitamina K]] para a súa síntese.
O [[xene]] do factor X humano está situado no [[cromosoma 13]] na posición 13q34.
 
== papelPapel en enfermidades ==
InbornA deficiency[[deficiencia ofde factor X]] conxénita is very rare (1:1,000,000), and may present with [[epistaxis]] (nosebleeds), [[hemarthrosis]] (bleeding into joints) and gastrointestinal blood loss. Apart from congenital deficiency, low factor X levels may occur occasionally in a number of disease states. For example, factor X deficiency may be seen in [[amyloidosis]], where factor X is adsorbed to the amyloid fibrils in the vasculature.
{{main|Factor X deficiency}}
Inborn deficiency of factor X is very rare (1:1,000,000), and may present with [[epistaxis]] (nosebleeds), [[hemarthrosis]] (bleeding into joints) and gastrointestinal blood loss. Apart from congenital deficiency, low factor X levels may occur occasionally in a number of disease states. For example, factor X deficiency may be seen in [[amyloidosis]], where factor X is adsorbed to the amyloid fibrils in the vasculature.
 
Deficiency of vitamin K or antagonism by [[warfarin]] (or similar medication) leads to the production of an inactive factor X. In warfarin therapy, this is desirable to prevent [[thrombosis]]. As of late 2007, four out of five emerging [[Anticoagulant|anti-coagulation]] therapeutics targeted this enzyme.<ref name="WSJOct2007">{{cite news
 
== Factor Xa ==
[[FileFicheiro:Coagulation in vivo-gl.png|right|thumbminiatura|350px|BloodVías coagulationda pathwayscoagulación do sangue ''in vivo'' showingmostrando theo papel central roleda played by thrombintrombina.]]
Factor Xa is the activated form of the [[coagulation factor]] [[thrombokinase]], known eponymously as Stuart-Prower factor. Factor X is an [[enzyme]], a [[serine endopeptidase]], which plays a key role at several stages of the [[coagulation system]]. Factor X is [[Biosynthesis|synthesized]] in the [[liver]]. The most commonly used [[anticoagulants]] in clinical practice, [[warfarin]] and the [[heparin]] series of anticoagulants and [[fondaparinux]], act to inhibit the action of Factor Xa in various degrees.
 
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