Diferenzas entre revisións de «Factor de crecemento de hepatocitos»

 
O HGF foi implicadoen diversos [[cancro]]s, como o de [[pulmón]], [[páncreas]], [[tiroide]], [[colon]] e [[cancro de mama|mama]].<ref name="ZieglerPierce2012">{{cite book|author1=Thomas R. Ziegler|author2=Glenn F. Pierce|author3=David N. Herndon|title=Growth Factors and Wound Healing: Basic Science and Potential Clinical Applications|url=https://books.google.com/books?id=5ct9BwAAQBAJ&pg=PA311|date=6 December 2012|publisher=Springer Science & Business Media|isbn=978-1-4612-1876-0|pages=311–}}</ref><ref name="pmid15767355">{{cite journal | vauthors = Sheen-Chen SM, Liu YW, Eng HL, Chou FF | title = Serum levels of hepatocyte growth factor in patients with breast cancer | journal = Cancer Epidemiology, Biomarkers & Prevention | volume = 14 | issue = 3 | pages = 715–7 | date = March 2005 | pmid = 15767355 | doi = 10.1158/1055-9965.EPI-04-0340 }}</ref><ref name="pmid21934211">{{cite journal | vauthors = El-Attar HA, Sheta MI | title = Hepatocyte growth factor profile with breast cancer | journal = Indian Journal of Pathology & Microbiology | volume = 54 | issue = 3 | pages = 509–13 | year = 2011 | pmid = 21934211 | doi = 10.4103/0377-4929.85083 }}</ref>
 
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IncreasedO expressionincremento ofda expresión de HGF hasfoi beenasociada associatedcoas withcapacidades thede enhancedmellora ande scarlessnon formación de cicatriz na [[woundcuración healingde feridas]] capabilities ofde [[fibroblastfibroblasto]]s cellsillados isolateddo fromtecido theda [[oral mucosa oral]] tissue.<ref>{{cite journal | vauthors = Dally J, Khan JS, Voisey A, Charalambous C, John HL, Woods EL, Steadman R, Moseley R, Midgley AC | title = Hepatocyte Growth Factor Mediates Enhanced Wound Healing Responses and Resistance to Transforming Growth Factor-β₁-Driven Myofibroblast Differentiation in Oral Mucosal Fibroblasts | journal = International Journal of Molecular Sciences | volume = 18 | issue = 9 | date = August 2017 | pmid = 28837064 | pmc = 5618492 | doi = 10.3390/ijms18091843 }}</ref>.
 
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=== Niveis de plasma circulantes ===
O [[plasma sanguíneo|plasma]] de pacientes con insuficiencia cardíaca avanzada presenta niveis incrementados de HGF, o cal se correlaciona cun prognóstico negativo e un alto risco de mortalidade.<ref>{{cite journal | vauthors = Richter B, Koller L, Hohensinner PJ, Zorn G, Brekalo M, Berger R, Mörtl D, Maurer G, Pacher R, Huber K, Wojta J, Hülsmann M, Niessner A | title = A multi-biomarker risk score improves prediction of long-term mortality in patients with advanced heart failure | journal = International Journal of Cardiology | volume = 168 | issue = 2 | pages = 1251–7 | date = September 2013 | pmid = 23218577 | doi = 10.1016/j.ijcard.2012.11.052 }}</ref><ref>{{cite journal | vauthors = Rychli K, Richter B, Hohensinner PJ, Kariem Mahdy A, Neuhold S, Zorn G, Berger R, Mörtl D, Huber K, Pacher R, Wojta J, Niessner A, Hülsmann M | title = Hepatocyte growth factor is a strong predictor of mortality in patients with advanced heart failure | journal = Heart | volume = 97 | issue = 14 | pages = 1158–63 | date = July 2011 | pmid = 21572126 | doi = 10.1136/hrt.2010.220228 }}</ref> O HGF circulante foi tamén identificado como marcador de prognóstico de gravidde en pacientes que padecen hipertensxión.<ref name="ReferenceB">{{cite journal | vauthors = Nakamura S, Morishita R, Moriguchi A, Yo Y, Nakamura Y, Hayashi S, Matsumoto K, Matsumoto K, Nakamura T, Higaki J, Ogihara T | title = Hepatocyte growth factor as a potential index of complication in diabetes mellitus | journal = Journal of Hypertension | volume = 16 | issue = 12 Pt 2 | pages = 2019–26 | date = December 1998 | pmid = 9886892 | doi = 10.1291/hypres.22.161 }}</ref><ref name="ReferenceB"/> O HGF circulante tamén se suxeriu como posible [[biomarcador]] precoz da fase aguda da [[inflamación]] intestinal.<ref>{{cite journal | vauthors = Sorour AE, Lönn J, Nakka SS, Nayeri T, Nayeri F | title = Evaluation of hepatocyte growth factor as a local acute phase response marker in the bowel: the clinical impact of a rapid diagnostic test for immediate identification of acute bowel inflammation | journal = Cytokine | volume = 71 | issue = 1 | pages = 8–15 | date = January 2015 | pmid = 25174881 | doi = 10.1016/j.cyto.2014.07.255 }}</ref>
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