Diferenzas entre revisións de «Factor de crecemento de hepatocitos»

 
A expresión excesiva local de HGF nas [[glándula mamaria|mamas]] foi implicada na [[macromastia]].<ref name="ZhongWang2014">{{cite journal | vauthors = Zhong A, Wang G, Yang J, Xu Q, Yuan Q, Yang Y, Xia Y, Guo K, Horch RE, Sun J | title = Stromal-epithelial cell interactions and alteration of branching morphogenesis in macromastic mammary glands | journal = Journal of Cellular and Molecular Medicine | volume = 18 | issue = 7 | pages = 1257–66 | date = July 2014 | pmid = 24720804 | doi = 10.1111/jcmm.12275 | pmc=4124011}}</ref> O HGFestá tamén implicado de forma importante no desenvolvemento normal da [[glándula mamaria]].<ref name="pmid7555716">{{vcite2 journal | vauthors = Niranjan B, Buluwela L, Yant J, Perusinghe N, Atherton A, Phippard D, Dale T, Gusterson B, Kamalati T | title = HGF/SF: a potent cytokine for mammary growth, morphogenesis and development | journal = Development | volume = 121 | issue = 9 | pages = 2897–908 | year = 1995 | pmid = 7555716 | doi = | url = }}</ref><ref name="pmid10219907">{{vcite2 journal | vauthors = Kamalati T, Niranjan B, Yant J, Buluwela L | title = HGF/SF in mammary epithelial growth and morphogenesis: in vitro and in vivo models | journal = J Mammary Gland Biol Neoplasia | volume = 4 | issue = 1 | pages = 69–77 | year = 1999 | pmid = 10219907 | doi = | url = }}</ref>
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HGF has been implicated in a variety of [[cancer]]s, including of the [[lung]]s, [[pancreas]], [[thyroid]], [[Large intestine|colon]], and [[breast]].<ref name="ZieglerPierce2012">{{cite book|author1=Thomas R. Ziegler|author2=Glenn F. Pierce|author3=David N. Herndon|title=Growth Factors and Wound Healing: Basic Science and Potential Clinical Applications|url=https://books.google.com/books?id=5ct9BwAAQBAJ&pg=PA311|date=6 December 2012|publisher=Springer Science & Business Media|isbn=978-1-4612-1876-0|pages=311–}}</ref><ref name="pmid15767355">{{cite journal | vauthors = Sheen-Chen SM, Liu YW, Eng HL, Chou FF | title = Serum levels of hepatocyte growth factor in patients with breast cancer | journal = Cancer Epidemiology, Biomarkers & Prevention | volume = 14 | issue = 3 | pages = 715–7 | date = March 2005 | pmid = 15767355 | doi = 10.1158/1055-9965.EPI-04-0340 }}</ref><ref name="pmid21934211">{{cite journal | vauthors = El-Attar HA, Sheta MI | title = Hepatocyte growth factor profile with breast cancer | journal = Indian Journal of Pathology & Microbiology | volume = 54 | issue = 3 | pages = 509–13 | year = 2011 | pmid = 21934211 | doi = 10.4103/0377-4929.85083 }}</ref>
 
O HGF hasfoi beenimplicadoen implicated in a variety ofdiversos [[cancercancro]]s, includingcomo ofo thede [[lungpulmón]]s, [[pancreaspáncreas]], [[thyroidtiroide]], [[Large intestine|colon]], ande [[breastcancro de mama|mama]].<ref name="ZieglerPierce2012">{{cite book|author1=Thomas R. Ziegler|author2=Glenn F. Pierce|author3=David N. Herndon|title=Growth Factors and Wound Healing: Basic Science and Potential Clinical Applications|url=https://books.google.com/books?id=5ct9BwAAQBAJ&pg=PA311|date=6 December 2012|publisher=Springer Science & Business Media|isbn=978-1-4612-1876-0|pages=311–}}</ref><ref name="pmid15767355">{{cite journal | vauthors = Sheen-Chen SM, Liu YW, Eng HL, Chou FF | title = Serum levels of hepatocyte growth factor in patients with breast cancer | journal = Cancer Epidemiology, Biomarkers & Prevention | volume = 14 | issue = 3 | pages = 715–7 | date = March 2005 | pmid = 15767355 | doi = 10.1158/1055-9965.EPI-04-0340 }}</ref><ref name="pmid21934211">{{cite journal | vauthors = El-Attar HA, Sheta MI | title = Hepatocyte growth factor profile with breast cancer | journal = Indian Journal of Pathology & Microbiology | volume = 54 | issue = 3 | pages = 509–13 | year = 2011 | pmid = 21934211 | doi = 10.4103/0377-4929.85083 }}</ref>
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Increased expression of HGF has been associated with the enhanced and scarless [[wound healing]] capabilities of [[fibroblast]] cells isolated from the [[oral mucosa]] tissue<ref>{{cite journal | vauthors = Dally J, Khan JS, Voisey A, Charalambous C, John HL, Woods EL, Steadman R, Moseley R, Midgley AC | title = Hepatocyte Growth Factor Mediates Enhanced Wound Healing Responses and Resistance to Transforming Growth Factor-β₁-Driven Myofibroblast Differentiation in Oral Mucosal Fibroblasts | journal = International Journal of Molecular Sciences | volume = 18 | issue = 9 | date = August 2017 | pmid = 28837064 | pmc = 5618492 | doi = 10.3390/ijms18091843 }}</ref>.
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