Diferenzas entre revisións de «Factor de crecemento de hepatocitos»

A [[terapia de ADN de plásmido de HGF humano]] de [[cardiomiocito]]s está sendo examinada como posible tratamento da [[enfermidade da arteria coronaria]] e como traramento para os danos ocorridos no corazón despois dun [[infarto de miocardio]].<ref name=YangZhang2008>{{cite journal | vauthors = Yang ZJ, Zhang YR, Chen B, Zhang SL, Jia EZ, Wang LS, Zhu TB, Li CJ, Wang H, Huang J, Cao KJ, Ma WZ, Wu B, Wang LS, Wu CT | title = Phase I clinical trial on intracoronary administration of Ad-hHGF treating severe coronary artery disease | journal = Molecular Biology Reports | volume = 36 | issue = 6 | pages = 1323–9 | date = July 2009 | pmid = 18649012 | pmc = | doi = 10.1007/s11033-008-9315-3 }}</ref><ref name=HahnPyun2011>{{cite journal | vauthors = Hahn W, Pyun WB, Kim DS, Yoo WS, Lee SD, Won JH, Shin GJ, Kim JM, Kim S | title = Enhanced cardioprotective effects by coexpression of two isoforms of hepatocyte growth factor from naked plasmid DNA in a rat ischemic heart disease model | journal = The Journal of Gene Medicine | volume = 13 | issue = 10 | pages = 549–55 | date = October 2011 | pmid = 21898720 | pmc = | doi = 10.1002/jgm.1603 }}</ref>
Ademais dos efectos ben caracterizados do HGF sobre as células epitaliais, endoteliais e proxenitoras hematopoéticas, o HGF tamén regula a [[quimiotaxe]] de células T no tecido cardíaco. A unión do HGF o c-Met, expresado en células T, causa a regulación á alza de c-Met, [[CXCR3]] e [[CCR4]], que á súa vez lles dá a capacidade de migrar ao tecido cardíaco.<ref name="pmid26070483">{{cite journal | vauthors = Komarowska I, Coe D, Wang G, Haas R, Mauro C, Kishore M, Cooper D, Nadkarni S, Fu H, Steinbruchel DA, Pitzalis C, Anderson G, Bucy P, Lombardi G, Breckenridge R, Marelli-Berg FM | title = Hepatocyte Growth Factor Receptor c-Met Instructs T Cell Cardiotropism and Promotes T Cell Migration to the Heart via Autocrine Chemokine Release | journal = Immunity | volume = 42 | issue = 6 | pages = 1087–99 | date = September 2016 | pmid = 26070483 | pmc = 4510150 | doi = 10.1016/j.immuni.2015.05.014 }}</ref> O HGF tamén promociona a anxioxénese nas lesións isquémicas. <ref>{{cite journal | vauthors = Chang HK, Kim PH, Cho, HM, Yum, SY, Choi, YJ, Lee D, Kang I, Kang KS, Jang G, Cho JY| title = Inducible HGF-secreting Human Umbilical Cord Blood-derived MSCs Produced via TALEN-mediated Genome Editing Promoted Angiogenesis | journal = Molecular Therapy | volume = 24 | issue = 9 | pages = 1644-54 | date = Sep 2016 | pmid = 27434585 | pmc = 5113099 | doi = 10.1038/mt.2016.120 }}</ref>
O HGF pode xogar un papel como indicador de prognóstico para a [àrtralxia[artralxia]]+ inducida polo [[virus]] [[Chikungunya]]. Os niveis altos de HGF correlaciónanse con altas taxas de recuperación.<ref name="pmid21288813">{{cite journal | vauthors = Chow A, Her Z, Ong EK, Chen JM, Dimatatac F, Kwek DJ, Barkham T, Yang H, Rénia L, Leo YS, Ng LF | title = Persistent arthralgia induced by Chikungunya virus infection is associated with interleukin-6 and granulocyte macrophage colony-stimulating factor | journal = The Journal of Infectious Diseases | volume = 203 | issue = 2 | pages = 149–57 | date = January 2011 | pmid = 21288813 | pmc = 3071069 | doi = 10.1093/infdis/jiq042 }}</ref>
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Excessive local expression of HGF in the [[breast]]s has been implicated in [[macromastia]].<ref name="ZhongWang2014">{{cite journal | vauthors = Zhong A, Wang G, Yang J, Xu Q, Yuan Q, Yang Y, Xia Y, Guo K, Horch RE, Sun J | title = Stromal-epithelial cell interactions and alteration of branching morphogenesis in macromastic mammary glands | journal = Journal of Cellular and Molecular Medicine | volume = 18 | issue = 7 | pages = 1257–66 | date = July 2014 | pmid = 24720804 | doi = 10.1111/jcmm.12275 | pmc=4124011}}</ref> HGF is also importantly involved in normal [[mammary gland]] development.<ref name="pmid7555716">{{vcite2 journal | vauthors = Niranjan B, Buluwela L, Yant J, Perusinghe N, Atherton A, Phippard D, Dale T, Gusterson B, Kamalati T | title = HGF/SF: a potent cytokine for mammary growth, morphogenesis and development | journal = Development | volume = 121 | issue = 9 | pages = 2897–908 | year = 1995 | pmid = 7555716 | doi = | url = }}</ref><ref name="pmid10219907">{{vcite2 journal | vauthors = Kamalati T, Niranjan B, Yant J, Buluwela L | title = HGF/SF in mammary epithelial growth and morphogenesis: in vitro and in vivo models | journal = J Mammary Gland Biol Neoplasia | volume = 4 | issue = 1 | pages = 69–77 | year = 1999 | pmid = 10219907 | doi = | url = }}</ref>
 
ExcessiveA expresión excesiva local expression ofde HGF in thenas [[breastglándula mamaria|mamas]]s hasfoi beenimplicada implicated inna [[macromastia]].<ref name="ZhongWang2014">{{cite journal | vauthors = Zhong A, Wang G, Yang J, Xu Q, Yuan Q, Yang Y, Xia Y, Guo K, Horch RE, Sun J | title = Stromal-epithelial cell interactions and alteration of branching morphogenesis in macromastic mammary glands | journal = Journal of Cellular and Molecular Medicine | volume = 18 | issue = 7 | pages = 1257–66 | date = July 2014 | pmid = 24720804 | doi = 10.1111/jcmm.12275 | pmc=4124011}}</ref> HGFO isHGFestá alsotamén importantlyimplicado involvedde informa importante no desenvolvemento normal da [[mammaryglándula glandmamaria]] development.<ref name="pmid7555716">{{vcite2 journal | vauthors = Niranjan B, Buluwela L, Yant J, Perusinghe N, Atherton A, Phippard D, Dale T, Gusterson B, Kamalati T | title = HGF/SF: a potent cytokine for mammary growth, morphogenesis and development | journal = Development | volume = 121 | issue = 9 | pages = 2897–908 | year = 1995 | pmid = 7555716 | doi = | url = }}</ref><ref name="pmid10219907">{{vcite2 journal | vauthors = Kamalati T, Niranjan B, Yant J, Buluwela L | title = HGF/SF in mammary epithelial growth and morphogenesis: in vitro and in vivo models | journal = J Mammary Gland Biol Neoplasia | volume = 4 | issue = 1 | pages = 69–77 | year = 1999 | pmid = 10219907 | doi = | url = }}</ref>
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HGF has been implicated in a variety of [[cancer]]s, including of the [[lung]]s, [[pancreas]], [[thyroid]], [[Large intestine|colon]], and [[breast]].<ref name="ZieglerPierce2012">{{cite book|author1=Thomas R. Ziegler|author2=Glenn F. Pierce|author3=David N. Herndon|title=Growth Factors and Wound Healing: Basic Science and Potential Clinical Applications|url=https://books.google.com/books?id=5ct9BwAAQBAJ&pg=PA311|date=6 December 2012|publisher=Springer Science & Business Media|isbn=978-1-4612-1876-0|pages=311–}}</ref><ref name="pmid15767355">{{cite journal | vauthors = Sheen-Chen SM, Liu YW, Eng HL, Chou FF | title = Serum levels of hepatocyte growth factor in patients with breast cancer | journal = Cancer Epidemiology, Biomarkers & Prevention | volume = 14 | issue = 3 | pages = 715–7 | date = March 2005 | pmid = 15767355 | doi = 10.1158/1055-9965.EPI-04-0340 }}</ref><ref name="pmid21934211">{{cite journal | vauthors = El-Attar HA, Sheta MI | title = Hepatocyte growth factor profile with breast cancer | journal = Indian Journal of Pathology & Microbiology | volume = 54 | issue = 3 | pages = 509–13 | year = 2011 | pmid = 21934211 | doi = 10.4103/0377-4929.85083 }}</ref>
 
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