Diferenzas entre revisións de «Factor de crecemento de hepatocitos»

 
== Importancia clínica ==
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A [[terapia de ADN de plásmido de HGF humano]] de [[cardiomiocito]]s está sendo examinada como posible tratamento da [[enfermidade da arteria coronaria]] e como traramento para os danos ocorridos no corazón despois dun [[infarto de miocardio]].<ref name=YangZhang2008>{{cite journal | vauthors = Yang ZJ, Zhang YR, Chen B, Zhang SL, Jia EZ, Wang LS, Zhu TB, Li CJ, Wang H, Huang J, Cao KJ, Ma WZ, Wu B, Wang LS, Wu CT | title = Phase I clinical trial on intracoronary administration of Ad-hHGF treating severe coronary artery disease | journal = Molecular Biology Reports | volume = 36 | issue = 6 | pages = 1323–9 | date = July 2009 | pmid = 18649012 | pmc = | doi = 10.1007/s11033-008-9315-3 }}</ref><ref name=HahnPyun2011>{{cite journal | vauthors = Hahn W, Pyun WB, Kim DS, Yoo WS, Lee SD, Won JH, Shin GJ, Kim JM, Kim S | title = Enhanced cardioprotective effects by coexpression of two isoforms of hepatocyte growth factor from naked plasmid DNA in a rat ischemic heart disease model | journal = The Journal of Gene Medicine | volume = 13 | issue = 10 | pages = 549–55 | date = October 2011 | pmid = 21898720 | pmc = | doi = 10.1002/jgm.1603 }}</ref>
Ademais dos efectos ben caracterizados do HGF sobre as células epitaliais, endoteliais e proxenitoras hematopoéticas, o HGF tamén regula a [[quimiotaxe]] de células T no tecido cardíaco. A unión do HGF o c-Met, expresado en células T, causa a regulación á alza de c-Met, [[CXCR3]] e [[CCR4]], que á súa vez lles dá a capacidade de migrar ao tecido cardíaco.<ref name="pmid26070483">{{cite journal | vauthors = Komarowska I, Coe D, Wang G, Haas R, Mauro C, Kishore M, Cooper D, Nadkarni S, Fu H, Steinbruchel DA, Pitzalis C, Anderson G, Bucy P, Lombardi G, Breckenridge R, Marelli-Berg FM | title = Hepatocyte Growth Factor Receptor c-Met Instructs T Cell Cardiotropism and Promotes T Cell Migration to the Heart via Autocrine Chemokine Release | journal = Immunity | volume = 42 | issue = 6 | pages = 1087–99 | date = September 2016 | pmid = 26070483 | pmc = 4510150 | doi = 10.1016/j.immuni.2015.05.014 }}</ref> HGF also promotes angiogenesis in ischemia injury. <ref>{{cite journal | vauthors = Chang HK, Kim PH, Cho, HM, Yum, SY, Choi, YJ, Lee D, Kang I, Kang KS, Jang G, Cho JY| title = Inducible HGF-secreting Human Umbilical Cord Blood-derived MSCs Produced via TALEN-mediated Genome Editing Promoted Angiogenesis | journal = Molecular Therapy | volume = 24 | issue = 9 | pages = 1644-54 | date = Sep 2016 | pmid = 27434585 | pmc = 5113099 | doi = 10.1038/mt.2016.120 }}</ref>
HGF may further play a role as an indicator for prognosis of chronicity for [[Chikungunya]] virus induced [[arthralgia]]. High HGF levels correlate with high rates of recovery.<ref name="pmid21288813">{{cite journal | vauthors = Chow A, Her Z, Ong EK, Chen JM, Dimatatac F, Kwek DJ, Barkham T, Yang H, Rénia L, Leo YS, Ng LF | title = Persistent arthralgia induced by Chikungunya virus infection is associated with interleukin-6 and granulocyte macrophage colony-stimulating factor | journal = The Journal of Infectious Diseases | volume = 203 | issue = 2 | pages = 149–57 | date = January 2011 | pmid = 21288813 | pmc = 3071069 | doi = 10.1093/infdis/jiq042 }}</ref>
 
A [[terapia de ADN de plásmido de HGF humano]] de [[cardiomiocito]]s está sendo examinada como posible tratamento da [[enfermidade da arteria coronaria]] e como traramento para os danos ocorridos no corazón despois dun [[infarto de miocardio]].<ref name=YangZhang2008>{{cite journal | vauthors = Yang ZJ, Zhang YR, Chen B, Zhang SL, Jia EZ, Wang LS, Zhu TB, Li CJ, Wang H, Huang J, Cao KJ, Ma WZ, Wu B, Wang LS, Wu CT | title = Phase I clinical trial on intracoronary administration of Ad-hHGF treating severe coronary artery disease | journal = Molecular Biology Reports | volume = 36 | issue = 6 | pages = 1323–9 | date = July 2009 | pmid = 18649012 | pmc = | doi = 10.1007/s11033-008-9315-3 }}</ref><ref name=HahnPyun2011>{{cite journal | vauthors = Hahn W, Pyun WB, Kim DS, Yoo WS, Lee SD, Won JH, Shin GJ, Kim JM, Kim S | title = Enhanced cardioprotective effects by coexpression of two isoforms of hepatocyte growth factor from naked plasmid DNA in a rat ischemic heart disease model | journal = The Journal of Gene Medicine | volume = 13 | issue = 10 | pages = 549–55 | date = October 2011 | pmid = 21898720 | pmc = | doi = 10.1002/jgm.1603 }}</ref>
Ademais dos efectos ben caracterizados do HGF sobre as células epitaliais, endoteliais e proxenitoras hematopoéticas, o HGF tamén regula a [[quimiotaxe]] de células T no tecido cardíaco. A unión do HGF o c-Met, expresado en células T, causa a regulación á alza de c-Met, [[CXCR3]] e [[CCR4]], que á súa vez lles dá a capacidade de migrar ao tecido cardíaco.<ref name="pmid26070483">{{cite journal | vauthors = Komarowska I, Coe D, Wang G, Haas R, Mauro C, Kishore M, Cooper D, Nadkarni S, Fu H, Steinbruchel DA, Pitzalis C, Anderson G, Bucy P, Lombardi G, Breckenridge R, Marelli-Berg FM | title = Hepatocyte Growth Factor Receptor c-Met Instructs T Cell Cardiotropism and Promotes T Cell Migration to the Heart via Autocrine Chemokine Release | journal = Immunity | volume = 42 | issue = 6 | pages = 1087–99 | date = September 2016 | pmid = 26070483 | pmc = 4510150 | doi = 10.1016/j.immuni.2015.05.014 }}</ref> O HGF alsotamén promociona promotesa angiogenesisanxioxénese innas ischemialesións injuryisquémicas. <ref>{{cite journal | vauthors = Chang HK, Kim PH, Cho, HM, Yum, SY, Choi, YJ, Lee D, Kang I, Kang KS, Jang G, Cho JY| title = Inducible HGF-secreting Human Umbilical Cord Blood-derived MSCs Produced via TALEN-mediated Genome Editing Promoted Angiogenesis | journal = Molecular Therapy | volume = 24 | issue = 9 | pages = 1644-54 | date = Sep 2016 | pmid = 27434585 | pmc = 5113099 | doi = 10.1038/mt.2016.120 }}</ref>
O HGF maypode furtherxogar playun apapel rolecomo asindicador ande indicatorprognóstico forpara prognosisa of[àrtralxia]+ chronicityinducida forpolo [[Chikungunyavirus]] virus induced [[arthralgiaChikungunya]]. HighOs HGFniveis levelsaltos de HGF correlatecorrelaciónanse withcon highaltas ratestaxas ofde recoveryrecuperación.<ref name="pmid21288813">{{cite journal | vauthors = Chow A, Her Z, Ong EK, Chen JM, Dimatatac F, Kwek DJ, Barkham T, Yang H, Rénia L, Leo YS, Ng LF | title = Persistent arthralgia induced by Chikungunya virus infection is associated with interleukin-6 and granulocyte macrophage colony-stimulating factor | journal = The Journal of Infectious Diseases | volume = 203 | issue = 2 | pages = 149–57 | date = January 2011 | pmid = 21288813 | pmc = 3071069 | doi = 10.1093/infdis/jiq042 }}</ref>
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Excessive local expression of HGF in the [[breast]]s has been implicated in [[macromastia]].<ref name="ZhongWang2014">{{cite journal | vauthors = Zhong A, Wang G, Yang J, Xu Q, Yuan Q, Yang Y, Xia Y, Guo K, Horch RE, Sun J | title = Stromal-epithelial cell interactions and alteration of branching morphogenesis in macromastic mammary glands | journal = Journal of Cellular and Molecular Medicine | volume = 18 | issue = 7 | pages = 1257–66 | date = July 2014 | pmid = 24720804 | doi = 10.1111/jcmm.12275 | pmc=4124011}}</ref> HGF is also importantly involved in normal [[mammary gland]] development.<ref name="pmid7555716">{{vcite2 journal | vauthors = Niranjan B, Buluwela L, Yant J, Perusinghe N, Atherton A, Phippard D, Dale T, Gusterson B, Kamalati T | title = HGF/SF: a potent cytokine for mammary growth, morphogenesis and development | journal = Development | volume = 121 | issue = 9 | pages = 2897–908 | year = 1995 | pmid = 7555716 | doi = | url = }}</ref><ref name="pmid10219907">{{vcite2 journal | vauthors = Kamalati T, Niranjan B, Yant J, Buluwela L | title = HGF/SF in mammary epithelial growth and morphogenesis: in vitro and in vivo models | journal = J Mammary Gland Biol Neoplasia | volume = 4 | issue = 1 | pages = 69–77 | year = 1999 | pmid = 10219907 | doi = | url = }}</ref>
 
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