Diferenzas entre revisións de «Factor de crecemento de hepatocitos»

== Importancia clínica ==
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A [[Humanterapia HGFde plasmidADN DNAde therapyplásmido de HGF humano]] ofde [[cardiomyocytescardiomiocito]]s isestá beingsendo examinedexaminada ascomo aposible potentialtratamento treatment forda [[coronaryenfermidade da arteryarteria diseasecoronaria]] ase wellcomo astraramento treatmentpara foros thedanos damageocorridos thatno occurscorazón todespois the heart afterdun [[myocardialinfarto de infarctionmiocardio]].<ref name=YangZhang2008>{{cite journal | vauthors = Yang ZJ, Zhang YR, Chen B, Zhang SL, Jia EZ, Wang LS, Zhu TB, Li CJ, Wang H, Huang J, Cao KJ, Ma WZ, Wu B, Wang LS, Wu CT | title = Phase I clinical trial on intracoronary administration of Ad-hHGF treating severe coronary artery disease | journal = Molecular Biology Reports | volume = 36 | issue = 6 | pages = 1323–9 | date = July 2009 | pmid = 18649012 | pmc = | doi = 10.1007/s11033-008-9315-3 }}</ref><ref name=HahnPyun2011>{{cite journal | vauthors = Hahn W, Pyun WB, Kim DS, Yoo WS, Lee SD, Won JH, Shin GJ, Kim JM, Kim S | title = Enhanced cardioprotective effects by coexpression of two isoforms of hepatocyte growth factor from naked plasmid DNA in a rat ischemic heart disease model | journal = The Journal of Gene Medicine | volume = 13 | issue = 10 | pages = 549–55 | date = October 2011 | pmid = 21898720 | pmc = | doi = 10.1002/jgm.1603 }}</ref>
AsAdemais welldos asefectos theben well-characterisedcaracterizados effects ofdo HGF onsobre [[epithelialas células cell]]sepitaliais, [[endothelialendoteliais cell]]se andproxenitoras [[haemopoietichematopoéticas, progenitor cell]]s,o HGF alsotamén regulatesregula thea chemotaxis[[quimiotaxe]] ofde células T cellsno intotecido heart tissuecardíaco. BindingA unión ofdo HGF byo c-Met, expressedexpresado onen Tcélulas cellsT, causescausa a theregulación upregulationá ofalza de c-Met, [[CXCR3]], ande [[CCR4]], whichque iná turnsúa imbuesvez themlles with thea abilitycapacidade tode migratemigrar intoao hearttecido tissuecardíaco.<ref name="pmid26070483">{{cite journal | vauthors = Komarowska I, Coe D, Wang G, Haas R, Mauro C, Kishore M, Cooper D, Nadkarni S, Fu H, Steinbruchel DA, Pitzalis C, Anderson G, Bucy P, Lombardi G, Breckenridge R, Marelli-Berg FM | title = Hepatocyte Growth Factor Receptor c-Met Instructs T Cell Cardiotropism and Promotes T Cell Migration to the Heart via Autocrine Chemokine Release | journal = Immunity | volume = 42 | issue = 6 | pages = 1087–99 | date = September 2016 | pmid = 26070483 | pmc = 4510150 | doi = 10.1016/j.immuni.2015.05.014 }}</ref> HGF also promotes angiogenesis in ischemia injury. <ref>{{cite journal | vauthors = Chang HK, Kim PH, Cho, HM, Yum, SY, Choi, YJ, Lee D, Kang I, Kang KS, Jang G, Cho JY| title = Inducible HGF-secreting Human Umbilical Cord Blood-derived MSCs Produced via TALEN-mediated Genome Editing Promoted Angiogenesis | journal = Molecular Therapy | volume = 24 | issue = 9 | pages = 1644-54 | date = Sep 2016 | pmid = 27434585 | pmc = 5113099 | doi = 10.1038/mt.2016.120 }}</ref>
HGF may further play a role as an indicator for prognosis of chronicity for [[Chikungunya]] virus induced [[arthralgia]]. High HGF levels correlate with high rates of recovery.<ref name="pmid21288813">{{cite journal | vauthors = Chow A, Her Z, Ong EK, Chen JM, Dimatatac F, Kwek DJ, Barkham T, Yang H, Rénia L, Leo YS, Ng LF | title = Persistent arthralgia induced by Chikungunya virus infection is associated with interleukin-6 and granulocyte macrophage colony-stimulating factor | journal = The Journal of Infectious Diseases | volume = 203 | issue = 2 | pages = 149–57 | date = January 2011 | pmid = 21288813 | pmc = 3071069 | doi = 10.1093/infdis/jiq042 }}</ref>
 
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