Diferenzas entre revisións de «Factor de crecemento de hepatocitos»

 
Increased expression of HGF has been associated with the enhanced and scarless [[wound healing]] capabilities of [[fibroblast]] cells isolated from the [[oral mucosa]] tissue<ref>{{cite journal | vauthors = Dally J, Khan JS, Voisey A, Charalambous C, John HL, Woods EL, Steadman R, Moseley R, Midgley AC | title = Hepatocyte Growth Factor Mediates Enhanced Wound Healing Responses and Resistance to Transforming Growth Factor-β₁-Driven Myofibroblast Differentiation in Oral Mucosal Fibroblasts | journal = International Journal of Molecular Sciences | volume = 18 | issue = 9 | date = August 2017 | pmid = 28837064 | pmc = 5618492 | doi = 10.3390/ijms18091843 }}</ref>.
 
=== Niveis de plasma circulantes ===
Plasma from patients with advanced heart failure presents increased levels of HGF, which correlates with a negative prognosis and a high risk of mortality.<ref>{{cite journal | vauthors = Richter B, Koller L, Hohensinner PJ, Zorn G, Brekalo M, Berger R, Mörtl D, Maurer G, Pacher R, Huber K, Wojta J, Hülsmann M, Niessner A | title = A multi-biomarker risk score improves prediction of long-term mortality in patients with advanced heart failure | journal = International Journal of Cardiology | volume = 168 | issue = 2 | pages = 1251–7 | date = September 2013 | pmid = 23218577 | doi = 10.1016/j.ijcard.2012.11.052 }}</ref><ref>{{cite journal | vauthors = Rychli K, Richter B, Hohensinner PJ, Kariem Mahdy A, Neuhold S, Zorn G, Berger R, Mörtl D, Huber K, Pacher R, Wojta J, Niessner A, Hülsmann M | title = Hepatocyte growth factor is a strong predictor of mortality in patients with advanced heart failure | journal = Heart | volume = 97 | issue = 14 | pages = 1158–63 | date = July 2011 | pmid = 21572126 | doi = 10.1136/hrt.2010.220228 }}</ref> Circulating HGF has been also identified as a prognostic marker of severity in patients suffering from hypertension.<ref name="ReferenceB">{{cite journal | vauthors = Nakamura S, Morishita R, Moriguchi A, Yo Y, Nakamura Y, Hayashi S, Matsumoto K, Matsumoto K, Nakamura T, Higaki J, Ogihara T | title = Hepatocyte growth factor as a potential index of complication in diabetes mellitus | journal = Journal of Hypertension | volume = 16 | issue = 12 Pt 2 | pages = 2019–26 | date = December 1998 | pmid = 9886892 | doi = 10.1291/hypres.22.161 }}</ref><ref name="ReferenceB"/> Circulating HGF has been also suggested as a precocious biomarker for the acute phase of bowel inflammation.<ref>{{cite journal | vauthors = Sorour AE, Lönn J, Nakka SS, Nayeri T, Nayeri F | title = Evaluation of hepatocyte growth factor as a local acute phase response marker in the bowel: the clinical impact of a rapid diagnostic test for immediate identification of acute bowel inflammation | journal = Cytokine | volume = 71 | issue = 1 | pages = 8–15 | date = January 2015 | pmid = 25174881 | doi = 10.1016/j.cyto.2014.07.255 }}</ref>
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=== Niveis de plasma circulantes ===
PlasmaO from[[plasma patientssanguíneo|plasma]] withde advancedpacientes heartcon failureinsuficiencia presentscardíaca increasedavanzada levelspresenta ofniveis incrementados de HGF, whicho correlatescal withse acorrelaciona negativecun prognosisprognóstico andnegativo ae highun riskalto ofrisco mortalityde mortalidade.<ref>{{cite journal | vauthors = Richter B, Koller L, Hohensinner PJ, Zorn G, Brekalo M, Berger R, Mörtl D, Maurer G, Pacher R, Huber K, Wojta J, Hülsmann M, Niessner A | title = A multi-biomarker risk score improves prediction of long-term mortality in patients with advanced heart failure | journal = International Journal of Cardiology | volume = 168 | issue = 2 | pages = 1251–7 | date = September 2013 | pmid = 23218577 | doi = 10.1016/j.ijcard.2012.11.052 }}</ref><ref>{{cite journal | vauthors = Rychli K, Richter B, Hohensinner PJ, Kariem Mahdy A, Neuhold S, Zorn G, Berger R, Mörtl D, Huber K, Pacher R, Wojta J, Niessner A, Hülsmann M | title = Hepatocyte growth factor is a strong predictor of mortality in patients with advanced heart failure | journal = Heart | volume = 97 | issue = 14 | pages = 1158–63 | date = July 2011 | pmid = 21572126 | doi = 10.1136/hrt.2010.220228 }}</ref> CirculatingO HGF hascirculante beenfoi alsotamén identifiedidentificado ascomo amarcador prognosticde markerprognóstico ofde severitygravidde inen patientspacientes sufferingque frompadecen hypertensionhipertensxión.<ref name="ReferenceB">{{cite journal | vauthors = Nakamura S, Morishita R, Moriguchi A, Yo Y, Nakamura Y, Hayashi S, Matsumoto K, Matsumoto K, Nakamura T, Higaki J, Ogihara T | title = Hepatocyte growth factor as a potential index of complication in diabetes mellitus | journal = Journal of Hypertension | volume = 16 | issue = 12 Pt 2 | pages = 2019–26 | date = December 1998 | pmid = 9886892 | doi = 10.1291/hypres.22.161 }}</ref><ref name="ReferenceB"/> Circulating HGF has been also suggested as a precocious biomarker for the acute phase of bowel inflammation.<ref>{{cite journal | vauthors = Sorour AE, Lönn J, Nakka SS, Nayeri T, Nayeri F | title = Evaluation of hepatocyte growth factor as a local acute phase response marker in the bowel: the clinical impact of a rapid diagnostic test for immediate identification of acute bowel inflammation | journal = Cytokine | volume = 71 | issue = 1 | pages = 8–15 | date = January 2015 | pmid = 25174881 | doi = 10.1016/j.cyto.2014.07.255 }}</ref>
 
== Farmacocinética ==
O HGF exóxeno administrado por [[inxección intravenosa]] é eliminado rapidamente d circulación polo [[fígado]], e ten unha [[vida media]] de aproximadamente 4 minutos.<ref name="Yang2001">{{cite journal | vauthors = Yang J, Chen S, Huang L, Michalopoulos GK, Liu Y | title = Sustained expression of naked plasmid DNA encoding hepatocyte growth factor in mice promotes liver and overall body growth | journal = Hepatology | volume = 33 | issue = 4 | pages = 848–59 | date = April 2001 | pmid = 11283849 | pmc = 1821076 | doi = 10.1053/jhep.2001.23438 }}</ref><ref name="pmid8450646">{{cite journal | vauthors = Appasamy R, Tanabe M, Murase N, Zarnegar R, Venkataramanan R, Van Thiel DH, Michalopoulos GK | title = Hepatocyte growth factor, blood clearance, organ uptake, and biliary excretion in normal and partially hepatectomized rats | journal = Laboratory Investigation; A Journal of Technical Methods and Pathology | volume = 68 | issue = 3 | pages = 270–6 | date = March 1993 | pmid = 8450646 | doi = }}</ref><ref name="KatoLiu1994">{{cite journal | vauthors = Kato Y, Liu KX, Nakamura T, Sugiyama Y | title = Heparin-hepatocyte growth factor complex with low plasma clearance and retained hepatocyte proliferating activity | journal = Hepatology | volume = 20 | issue = 2 | pages = 417–24 | date = August 1994 | pmid = 8045504 | doi = 10.1002/hep.1840200223 }}</ref><ref name="YuYao2007">{{cite journal | vauthors = Yu Y, Yao AH, Chen N, Pu LY, Fan Y, Lv L, Sun BC, Li GQ, Wang XH | title = Mesenchymal stem cells over-expressing hepatocyte growth factor improve small-for-size liver grafts regeneration | journal = Molecular Therapy | volume = 15 | issue = 7 | pages = 1382–9 | date = July 2007 | pmid = 17519892 | doi = 10.1038/sj.mt.6300202 }}</ref>
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