Diferenzas entre revisións de «Factor de crecemento de hepatocitos»

Increased expression of HGF has been associated with the enhanced and scarless [[wound healing]] capabilities of [[fibroblast]] cells isolated from the [[oral mucosa]] tissue<ref>{{cite journal | vauthors = Dally J, Khan JS, Voisey A, Charalambous C, John HL, Woods EL, Steadman R, Moseley R, Midgley AC | title = Hepatocyte Growth Factor Mediates Enhanced Wound Healing Responses and Resistance to Transforming Growth Factor-β₁-Driven Myofibroblast Differentiation in Oral Mucosal Fibroblasts | journal = International Journal of Molecular Sciences | volume = 18 | issue = 9 | date = August 2017 | pmid = 28837064 | pmc = 5618492 | doi = 10.3390/ijms18091843 }}</ref>.
 
=== Niveis de plsmaplasma circulantes ===
Plasma from patients with advanced heart failure presents increased levels of HGF, which correlates with a negative prognosis and a high risk of mortality.<ref>{{cite journal | vauthors = Richter B, Koller L, Hohensinner PJ, Zorn G, Brekalo M, Berger R, Mörtl D, Maurer G, Pacher R, Huber K, Wojta J, Hülsmann M, Niessner A | title = A multi-biomarker risk score improves prediction of long-term mortality in patients with advanced heart failure | journal = International Journal of Cardiology | volume = 168 | issue = 2 | pages = 1251–7 | date = September 2013 | pmid = 23218577 | doi = 10.1016/j.ijcard.2012.11.052 }}</ref><ref>{{cite journal | vauthors = Rychli K, Richter B, Hohensinner PJ, Kariem Mahdy A, Neuhold S, Zorn G, Berger R, Mörtl D, Huber K, Pacher R, Wojta J, Niessner A, Hülsmann M | title = Hepatocyte growth factor is a strong predictor of mortality in patients with advanced heart failure | journal = Heart | volume = 97 | issue = 14 | pages = 1158–63 | date = July 2011 | pmid = 21572126 | doi = 10.1136/hrt.2010.220228 }}</ref> Circulating HGF has been also identified as a prognostic marker of severity in patients suffering from hypertension.<ref name="ReferenceB">{{cite journal | vauthors = Nakamura S, Morishita R, Moriguchi A, Yo Y, Nakamura Y, Hayashi S, Matsumoto K, Matsumoto K, Nakamura T, Higaki J, Ogihara T | title = Hepatocyte growth factor as a potential index of complication in diabetes mellitus | journal = Journal of Hypertension | volume = 16 | issue = 12 Pt 2 | pages = 2019–26 | date = December 1998 | pmid = 9886892 | doi = 10.1291/hypres.22.161 }}</ref><ref name="ReferenceB"/> Circulating HGF has been also suggested as a precocious biomarker for the acute phase of bowel inflammation.<ref>{{cite journal | vauthors = Sorour AE, Lönn J, Nakka SS, Nayeri T, Nayeri F | title = Evaluation of hepatocyte growth factor as a local acute phase response marker in the bowel: the clinical impact of a rapid diagnostic test for immediate identification of acute bowel inflammation | journal = Cytokine | volume = 71 | issue = 1 | pages = 8–15 | date = January 2015 | pmid = 25174881 | doi = 10.1016/j.cyto.2014.07.255 }}</ref>
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== Farmacocinética ==
[[Exogenous]]O HGF administeredexóxeno byadministrado por [[intravenousinxección injectionintravenosa]] isé clearedeliminado rapidlyrapidamente fromd circulationcirculación by thepolo [[liverfígado]], withe aten unha [[half-lifevida media]] ofde approximatelyaproximadamente 4 minutesminutos.<ref name="Yang2001">{{cite journal | vauthors = Yang J, Chen S, Huang L, Michalopoulos GK, Liu Y | title = Sustained expression of naked plasmid DNA encoding hepatocyte growth factor in mice promotes liver and overall body growth | journal = Hepatology | volume = 33 | issue = 4 | pages = 848–59 | date = April 2001 | pmid = 11283849 | pmc = 1821076 | doi = 10.1053/jhep.2001.23438 }}</ref><ref name="pmid8450646">{{cite journal | vauthors = Appasamy R, Tanabe M, Murase N, Zarnegar R, Venkataramanan R, Van Thiel DH, Michalopoulos GK | title = Hepatocyte growth factor, blood clearance, organ uptake, and biliary excretion in normal and partially hepatectomized rats | journal = Laboratory Investigation; A Journal of Technical Methods and Pathology | volume = 68 | issue = 3 | pages = 270–6 | date = March 1993 | pmid = 8450646 | doi = }}</ref><ref name="KatoLiu1994">{{cite journal | vauthors = Kato Y, Liu KX, Nakamura T, Sugiyama Y | title = Heparin-hepatocyte growth factor complex with low plasma clearance and retained hepatocyte proliferating activity | journal = Hepatology | volume = 20 | issue = 2 | pages = 417–24 | date = August 1994 | pmid = 8045504 | doi = 10.1002/hep.1840200223 }}</ref><ref name="YuYao2007">{{cite journal | vauthors = Yu Y, Yao AH, Chen N, Pu LY, Fan Y, Lv L, Sun BC, Li GQ, Wang XH | title = Mesenchymal stem cells over-expressing hepatocyte growth factor improve small-for-size liver grafts regeneration | journal = Molecular Therapy | volume = 15 | issue = 7 | pages = 1382–9 | date = July 2007 | pmid = 17519892 | doi = 10.1038/sj.mt.6300202 }}</ref>
 
== Moduladores ==
[[Dihexa]] isé an orally active, centrally penetrantunha [[small-moleculepequena molécula]] compoundoralmente thatactiva directlye bindspenetrante tocentralmente que se une directamente ao HGF ande potencia a potentiatessúa itscapacidade abilityde toactivar activateo itsseu receptor, c-Met.<ref name="BenoistKawas2014">{{cite journal | vauthors = Benoist CC, Kawas LH, Zhu M, Tyson KA, Stillmaker L, Appleyard SM, Wright JW, Wayman GA, Harding JW | title = The procognitive and synaptogenic effects of angiotensin IV-derived peptides are dependent on activation of the hepatocyte growth factor/c-met system | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 351 | issue = 2 | pages = 390–402 | date = November 2014 | pmid = 25187433 | pmc = 4201273 | doi = 10.1124/jpet.114.218735 }}</ref> ItÉ isun aforte strongindutor inducer ofda [[neurogenesisneuroxénese]] ande isestá beingsendo studiedestudado forpara thea potentialsúa treatmentposible ofaplicación no tratamento da [[Alzheimer'senfermidade diseasede Alzheimer]] ande a de [[Parkinson'senfermidde diseasede Parkinson|Parkinson]].<ref name="pmid25649658">{{cite journal | vauthors = Wright JW, Harding JW | title = The Brain Hepatocyte Growth Factor/c-Met Receptor System: A New Target for the Treatment of Alzheimer's Disease | journal = Journal of Alzheimer's Disease | volume = 45 | issue = 4 | pages = 985–1000 | year = 2015 | pmid = 25649658 | doi = 10.3233/JAD-142814 }}</ref><ref name="WrightKawas2015">{{cite journal | vauthors = Wright JW, Kawas LH, Harding JW | title = The development of small molecule angiotensin IV analogs to treat Alzheimer's and Parkinson's diseases | journal = Progress in Neurobiology | volume = 125 | pages = 26–46 | date = February 2015 | pmid = 25455861 | doi = 10.1016/j.pneurobio.2014.11.004 }}</ref>
 
== Interaccións ==
Hepatocyte growthO factor hasde beencrecemento shownde tohepatocitos presenta [[Protein-proteininteraccións interactionproteína-proteína|interactinteraccións]] withco theproduto proteinproteico productdo of theoncoxene c-Met oncogene, identifiedidentificado ascomo thereceptor de HGF receptor ([[c-Met|HGFR]]).<ref name="pmid1846706"/><ref name="pmid8380735">{{cite journal | vauthors = Comoglio PM | title = Structure, biosynthesis and biochemical properties of the HGF receptor in normal and malignant cells | journal = Exs | volume = 65 | issue = | pages = 131–65 | year = 1993 | pmid = 8380735 | doi = }}</ref><ref name="pmid1655405">{{cite journal | vauthors = Naldini L, Weidner KM, Vigna E, Gaudino G, Bardelli A, Ponzetto C, Narsimhan RP, Hartmann G, Zarnegar R, Michalopoulos GK | title = Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor | journal = The EMBO Journal | volume = 10 | issue = 10 | pages = 2867–78 | date = October 1991 | pmid = 1655405 | pmc = 452997 | doi = }}</ref> BothTanto overexpressiona ofsobreexpresión theda proteína do receptor Met/HGFR receptorcoma proteina andactivación [[Autocrinesinalización signallingautócrina|autocrineautócrina]] activation ofde Met/HGFR bypola simultaneousexpresión expressionsimultánea ofdo the[[ligando]] hepatocytefactor growthde factorcrecemento ligandde havehepatocitos beenfoi implicatedimplicado inna oncogenesisoncoxénese.<ref>{{cite journal | vauthors = Johnson M, Koukoulis G, Kochhar K, Kubo C, Nakamura T, Iyer A | title = Selective tumorigenesis in non-parenchymal liver epithelial cell lines by hepatocyte growth factor transfection | journal = Cancer Letters | volume = 96 | issue = 1 | pages = 37–48 | date = September 1995 | pmid = 7553606 | doi = 10.1016/0304-3835(95)03915-j }}</ref><ref>{{cite journal | vauthors = Kochhar KS, Johnson ME, Volpert O, Iyer AP | title = Evidence for autocrine basis of transformation in NIH-3T3 cells transfected with met/HGF receptor gene | journal = Growth Factors | volume = 12 | issue = 4 | pages = 303–13 | date = 1995 | pmid = 8930021 | doi = 10.3109/08977199509028968 }}</ref>
Hepatocyte growthO factor interactsde withcrecemento thede sulfatedhepatocitos glycosaminoglycansinteracciona heparancos sulfate[[glicosaminoglicano]]s andsufatados dermatan[[heparán sulfatesulfato]] e [[dermatán sulfato]].<ref name="ReferenceA">{{cite journal | vauthors = Lyon M, Deakin JA, Gallagher JT | title = The mode of action of heparan and dermatan sulfates in the regulation of hepatocyte growth factor/scatter factor | journal = The Journal of Biological Chemistry | volume = 277 | issue = 2 | pages = 1040–6 | date = January 2002 | pmid = 11689562 | doi = 10.1074/jbc.M107506200 }}</ref><ref>{{cite journal | vauthors = Lyon M, Deakin JA, Rahmoune H, Fernig DG, Nakamura T, Gallagher JT | title = Hepatocyte growth factor/scatter factor binds with high affinity to dermatan sulfate | journal = J Biol Chem | volume = 273 | issue = 1 | pages = 271–8. | date = Jan 1998 | PMID = 9417075 | doi = 10.1074/jbc.273.1.271 | url = http://www.jbc.org/content/273/1/271.long}}</ref> TheA interactioninteracción withco heparanheparán suflatesulfato allowspermite hepatocyteque growtho factor tode formcrecemento ade complexhepatocitos withforme un complexo con c-Met thatque ispode able[[transdución tode transducesinais|transducir intracellularsinais]] signalsintracelulares leadingque toorixinarán cella division[[división andcelular]] e a cell[[migración migrationcelular]].<ref name="ReferenceA"/><ref>{{cite journal | vauthors = Sergeant N, Lyon M, Rudland PS, Fernig DG, Delehedde M | title = Stimulation of DNA synthesis and cell proliferation of human mammary myoepithelial-like cells by hepatocyte growth factor/scatter factor depends on heparan sulfate proteoglycans and sustained phosphorylation of mitogen-activated protein kinases p42/44 | journal = The Journal of Biological Chemistry | volume = 275 | issue = 22 | pages = 17094–9 | date = June 2000 | pmid = 10747885 | doi = 10.1074/jbc.M000237200 }}</ref>
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== Notas ==
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edicións