Diferenzas entre revisións de «Factor de crecemento de hepatocitos»

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== Función ==
 
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Hepatocyte growthO factor regulatesde cellcrecemento growth,do hepatocito regula o cellcrecemento motilitycelular, anda motilidade celular e a [[morphogenesismorfoxénese]] byao activatingactivar a fervenza de sinalización da [[tyrosinetirosina kinasequinase]] signalingdespois cascadede afterunirse bindingao toreceptor the proto-oncogenicprotooncoxénico [[c-Met]] receptor.<ref name="pmid1846706">{{cite journal | vauthors = Bottaro DP, Rubin JS, Faletto DL, Chan AM, Kmiecik TE, Vande Woude GF, Aaronson SA | title = Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product | journal = Science | volume = 251 | issue = 4995 | pages = 802–4 | date = February 1991 | pmid = 1846706 | doi = 10.1126/science.1846706 }}</ref><ref>{{cite journal | vauthors = Johnson M, Koukoulis G, Matsumoto K, Nakamura T, Iyer A | title = Hepatocyte growth factor induces proliferation and morphogenesis in nonparenchymal epithelial liver cells | journal = Hepatology | volume = 17 | issue = 6 | pages = 1052–61 | date = June 1993 | pmid = 8514254 | doi = 10.1016/0270-9139(93)90122-4 }}</ref> HepatocyteO growthHGR factoré issegregado secreted bypolas [[mesenchymalcélula cellmasenquimal|células mesenquimais]]s ande actsactúa ascomo a multi-functionalunha [[cytokinecitocina]] onmultifuncional cellsen ofcélulas mainlyde epithelialorixe originprincipalmente epitelial. ItsA abilitysúa tocapacidade stimulatede estimular a [[mitogenesismitoxénese]], cellmotilidade motility,celular ande matrixinvasión invasionda gives[[matriz itextracelular|matriz]] adálle centralu rolepapel incentral na [[angiogenesisanxioxése]], [[tumorogenesistumoroxénese]], ande rexeneración tissuede regenerationtecidos.<ref name = "entrez" />
 
== Estrutura ==
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It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the [[plasminogen]] subfamily of S1 peptidases but has no detectable [[protease]] activity.<ref name = "entrez" >{{cite web | title = Entrez Gene: HGF hepatocyte growth factor (hepapoietin A; scatter factor)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3082| accessdate = }}</ref>
 
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