Factor de crecemento derivado de plaquetas: Diferenzas entre revisións

Os PDGF son mitoxénicos durante as etapas de desenvolvemento iniciais, fomentando a proliferación de [[mesénquima]] indiferenciado e algunhas poboacións de células proxenitoras. Durante os estados de maduración posteriores, a sinalización do PDGF foi implicada na remodelación dos tecidos e na [[diferenciación celular]], así como en eventos indutivos de creación de padróns e morfoxénese. Ademais de promover a proliferación mesenquimática, os PDGF dirixen a migración, diferenciación e funcionamento de diversos tipos celulares mesenquimais e migratorios especializados, tntotanto curantedurante o desenvolvemento coma no animal adulto.<ref>{{cite journal|last1=Ataliotis|first1=P|last2=Symes|first2=K|last3=Chou|first3=MM|last4=Ho|first4=L|last5=Mercola|first5=M|title=PDGF signalling is required for gastrulation of Xenopus laevis.|journal=Development|date=September 1995|volume=121|issue=9|pages=3099–110|pmid=7555734}}</ref><ref>{{cite journal|last1=Symes|first1=K|last2=Mercola|first2=M|title=Embryonic mesoderm cells spread in response to platelet-derived growth factor and signaling by phosphatidylinositol 3-kinase.|journal=Proceedings of the National Academy of Sciences of the United States of America|date=3 September 1996|volume=93|issue=18|pages=9641–4|pmid=8790383|doi=10.1073/pnas.93.18.9641|pmc=38481}}</ref><ref name="PUB00014075">{{cite journal |vauthors=Hoch RV, Soriano P | title = Roles of PDGF in animal development | journal = Development | volume = 130 | issue = 20 | pages = 4769–4784 | year = 2003 | pmid = 12952899 | doi = 10.1242/dev.00721 }}</ref> OtherOutros growthfactores factorsde increcemento thisdesta familyfamilia includeson vascularos endothelialfactores growthde crecemento factorsendotelial vascular B ande C (VEGF-B, VEGF-C),<ref name="PUB00004886">{{cite journal |vauthors=Olofsson B, Pajusola K, Kaipainen A, von Euler G, Joukov V, Saksela O, Orpana A, Pettersson RF, Alitalo K, Eriksson U | title = Vascular endothelial growth factor B, a novel growth factor for endothelial cells | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 93 | issue = 6 | pages = 2567–2581 | year = 1996 | pmid = 8637916 | pmc = 39839 | doi = 10.1073/pnas.93.6.2576 }}</ref><ref name="PUB00001288">{{cite journal |vauthors=Joukov V, Pajusola K, Kaipainen A, Chilov D, Lahtinen I, Kukk E, Saksela O, Kalkkinen N, Alitalo K | title = A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases | journal = EMBO J. | volume = 15 | issue = 2 | pages = 290–298 | year = 1996 | pmid = 8617204 | pmc = 449944 }}</ref> whichque areestán activeactivos inna angiogenesisanxioxénese ande endothelialo crecemento cellde growthcélulas endoteliais, ande placenta growtho factor de crecemento placentario (PlGF), whichque isestá alsotamén activeactivo inna angiogenesisanxioxénese.<ref name="PUB00004494">{{cite journal |vauthors=Maglione D, Guerriero V, Viglietto G, Ferraro MG, Aprelikova O, Alitalo K, Del Vecchio S, Lei KJ, Chou JY, Persico MG | title = Two alternative mRNAs coding for the angiogenic factor, placenta growth factor (PlGF), are transcribed from a single gene of chromosome 14 | journal = Oncogene | volume = 8 | issue = 4 | pages = 925–931 | year = 1993 | pmid = 7681160 }}</ref>