Diferenzas entre revisións de «Receptor da vitamina D»

 
== Función ==
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This gene encodes the nuclear hormone receptor for [[vitamin D3|vitamin D<sub>3</sub>]]. This receptor also functions as a receptor for the secondary [[bile acid]] [[lithocholic acid]]. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows similarity of sequence to the steroid and thyroid hormone receptors.<ref name="pmid17132848">{{cite journal | vauthors = Germain P, Staels B, Dacquet C, Spedding M, Laudet V | title = Overview of nomenclature of nuclear receptors | journal = Pharmacol. Rev. | volume = 58 | issue = 4 | pages = 685–704 | date = December 2006 | pmid = 17132848 | doi = 10.1124/pr.58.4.2 }}</ref>
 
ThisEste genexene encodescodifica theo receptor nuclear hormonede receptorhormonas forpara a [[vitaminvitamina D3|vitaminvitamina D<sub>3</sub>]] (calcitriol). ThisEste receptor alsotamén functionsfunciona as acomo receptor for thepara secondaryo [[bileácido acidbiliar]] secundario [[lithocholicácido acidlitocólico]]. TheO receptor belongspertence toá thefamilia familydos offactores reguladores transcricionais que actúas en trans-acting transcriptionale regulatorymostran factorsunha andsimilitude showsde similaritysecuencia ofcos sequencereceptores tode the[[hormona steroidtiroide|hormonas andtiroides]] thyroide hormone[[hormonas receptorsesteroides|esteroides]].<ref name="pmid17132848">{{cite journal | vauthors = Germain P, Staels B, Dacquet C, Spedding M, Laudet V | title = Overview of nomenclature of nuclear receptors | journal = Pharmacol. Rev. | volume = 58 | issue = 4 | pages = 685–704 | date = December 2006 | pmid = 17132848 | doi = 10.1124/pr.58.4.2 }}</ref>
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Downstream targets of this nuclear hormone receptor are involved principally in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer.<ref name="pmid16848743">{{cite journal | vauthors = Adorini L, Daniel KC, Penna G | title = Vitamin D receptor agonists, cancer and the immune system: an intricate relationship | journal = Curr Top Med Chem | volume = 6 | issue = 12 | pages = 1297–301 | year = 2006 | pmid = 16848743 | doi = 10.2174/156802606777864890 }}</ref>
 
These studies have revealed novel actions of the unliganded VDR in regulating the post-morphogenic hair cycle.
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