Diferenzas entre revisións de «DGCR8»

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Arranxos varios, replaced: {{cite web → {{Cita web, {{cite journal → {{Cita publicación periódica (10)
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A subunidade '''DGCR8''' do complexo microprocesador (iniciais en inglés de ''DiGeorge syndrome chromosomal'' [ou ''critical''] ''region 8'', ou "síndrome de DiGeorge cromosómica [ou crítica] rexión 8") é unha [[proteína]] que nos humanos está codificada no [[xene]] ''DGCR8'' do [[cromosoma 22]], que colabora no procesamento de [[miARN]] durante a [[interferencia de ARN]].<ref name="entrez">{{citeCita web | title = Entrez Gene: DGCR8 DiGeorge syndrome critical region gene 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54487| accessdate = }}</ref> Aínda que en [[mamíferos]] o nome que se lle dá é DGCR8, noutros animais como os [[organismo modelo|organismos modelo]] ''[[Drosophila melanogaster]]'' e ''[[Caenorhabditis elegans]]'', esta proteína coñecese co nome de '''Pasha''' (colaboradora de [[Drosha]]).<ref>{{citeCita journalpublicación periódica | author = Denli AM, Tops BB, Plasterk RH, Ketting RF, Hannon GJ | title = Processing of primary microRNAs by the Microprocessor complex | journal = Nature | volume = 432 | issue = 7014 | pages = 231–5 | date = Nov 2004 | pmid = 15531879 | doi = 10.1038/nature03049 }}</ref> En todos eses animais é un compoñente necesario da vía de interferencia de ARN.
 
== Función ==
 
A DGCR8 (ou Pasha) está localizada no [[núcleo celular]] e requírese para o procesamento do [[microARN]] (miARN). Únese á proteína [[Drosha]], que é un [[encima]] [[RNase III]], para formar o ''Complexo microprocesador'' que cliva un [[transcrito primario]] chamado pri-miARN para formar unha estrutura característica en [[talo-bucle]] chamada pre-miARN, o cal despois seguirá procesándose dando fragmentos de miARN pola acción do encima [[Dicer]]. A DGCR8 (ou Pasha) contén un [[dominio proteico|dominio]] de unión ao [[ARN]] e crese que se une ao pri-miARN para estabilizalo para poder ser procesado seguidamente por Drosha.<ref>{{citeCita journalpublicación periódica | author = Yeom KH, Lee Y, Han J, Suh MR, Kim VN | title = Characterization of DGCR8/Pasha, the essential cofactor for Drosha in primary miRNA processing | journal = Nucleic Acids Research | volume = 34 | issue = 16 | pages = 4622–9 | year = 2006 | pmid = 16963499 | pmc = 1636349 | doi = 10.1093/nar/gkl458 }}</ref>
 
== Notas ==
=== Bibliografía ===
 
* {{citeCita journalpublicación periódica | author = Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S | title = Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing | journal = EMBO Reports | volume = 1 | issue = 3 | pages = 287–92 | year = 2001 | date = Sep 2000 | pmid = 11256614 | pmc = 1083732 | doi = 10.1093/embo-reports/kvd058 }}
* {{citeCita journalpublicación periódica | author = Shiohama A, Sasaki T, Noda S, Minoshima S, Shimizu N | title = Molecular cloning and expression analysis of a novel gene DGCR8 located in the DiGeorge syndrome chromosomal region | journal = Biochemical and Biophysical Research Communications | volume = 304 | issue = 1 | pages = 184–90 | date = Apr 2003 | pmid = 12705904 | doi = 10.1016/S0006-291X(03)00554-0 }}
* {{citeCita journalpublicación periódica | author = Gregory RI, Yan KP, Amuthan G, Chendrimada T, Doratotaj B, Cooch N, Shiekhattar R | title = The Microprocessor complex mediates the genesis of microRNAs | journal = Nature | volume = 432 | issue = 7014 | pages = 235–40 | date = Nov 2004 | pmid = 15531877 | doi = 10.1038/nature03120 }}
* {{citeCita journalpublicación periódica | vauthors = Han J, Lee Y, Yeom KH, Kim YK, Jin H, Kim VN | title = The Drosha-DGCR8 complex in primary microRNA processing | journal = Genes & Development | volume = 18 | issue = 24 | pages = 3016–27 | year = 2005 | date = Dec 2004 | pmid = 15574589 | pmc = 535913 | doi = 10.1101/gad.1262504 }}
* {{citeCita journalpublicación periódica | author = Landthaler M, Yalcin A, Tuschl T | title = The human DiGeorge syndrome critical region gene 8 and Its D. melanogaster homolog are required for miRNA biogenesis | journal = Current Biology : CB | volume = 14 | issue = 23 | pages = 2162–7 | year = 2005 | date = Dec 2004 | pmid = 15589161 | doi = 10.1016/j.cub.2004.11.001 }}
* {{citeCita journalpublicación periódica | author = Han J, Lee Y, Yeom KH, Nam JW, Heo I, Rhee JK, Sohn SY, Cho Y, Zhang BT, Kim VN | title = Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex | journal = Cell | volume = 125 | issue = 5 | pages = 887–901 | date = Jun 2006 | pmid = 16751099 | doi = 10.1016/j.cell.2006.03.043 }}
* {{citeCita journalpublicación periódica | author = Faller M, Matsunaga M, Yin S, Loo JA, Guo F | title = Heme is involved in microRNA processing | journal = Nature Structural & Molecular Biology | volume = 14 | issue = 1 | pages = 23–9 | date = Jan 2007 | pmid = 17159994 | doi = 10.1038/nsmb1182 }}
* {{citeCita journalpublicación periódica | vauthors = Sohn SY, Bae WJ, Kim JJ, Yeom KH, Kim VN, Cho Y | title = Crystal structure of human DGCR8 core | journal = Nature Structural & Molecular Biology | volume = 14 | issue = 9 | pages = 847–53 | date = Sep 2007 | pmid = 17704815 | doi = 10.1038/nsmb1294 }}
 
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