Factor de crecemento endotelial vascular: Diferenzas entre revisións

A hipoxia regula á alza fortemente a expresión de VEGF e este exerce un efecto neuroprotector sobre as neuronas hipóxicas.<ref name="NHM IGF-1 VEGF">Malenka RC, Nestler EJ, Hyman SE (2009). Sydor A, Brown RY, ed. Molecular Neuropharmacology: A Foundation for Clinical Neuroscience (2nd ed.). New York: McGraw-Hill Medical. pp. 221, 412. ISBN 978-0-07-148127-4.</ref> O exercicio aeróbico incrementa a biosíntese de VEGF nos tecidos periféricos, que despois cruza a [[barreira hematoencefálica]] e promove a neuroxénese e anxioxénese no [[sistema nervioso central]].<ref name="Cerebral hemodynamics and AD">{{Cita publicación periódica |author = Tarumi T, Zhang R | title = Cerebral hemodynamics of the aging brain: risk of Alzheimer disease and benefit of aerobic exercise | journal = Front Physiol | volume = 5 | issue = | pages = 6 | date = January 2014 | pmid = 24478719 | pmc = 3896879 | doi = 10.3389/fphys.2014.00006}}</ref><ref name="Fitness mechanism" /><ref name="VEGF aging brain">{{Cita publicación periódica | author = Bouchard J, Villeda SA | title = Aging and brain rejuvenation as systemic events | journal = J. Neurochem. | volume = 132 | issue = 1 | pages = 5–19 | year = 2015 | pmid = 25327899 | pmc = 4301186 | doi = 10.1111/jnc.12969}}</ref> Os incrementos inducidos polo exercicio na sinalización por VEGF melloran o volume sanguíneo cerebral e contribúen á neuroxénese inducida polo exercicio no [[hipocampo]].<ref name="ComprehensiveFitness reviewmechanism" >Gomez-PinillaSilverman FMN, HillmanDeuster CPA (JanuaryOctober 20132014). "TheBiological influencemechanisms underlying the role of exercisephysical onfitness cognitivein abilitieshealth and resilience". ComprInterface PhysiolFocus 34 (15): 403–42820140040. doi:10.10021098/cphyrsfs.c1100632014. PMC 39519580040. PMID 23720292. 25285199</ref><ref name="FitnessVEGF mechanismaging brain" />Silverman<ref MNname="Comprehensive review">Gomez-Pinilla F, DeusterHillman PAC (OctoberJanuary 20142013). "BiologicalThe mechanisms underlying the roleinfluence of physicalexercise fitnesson incognitive health and resilienceabilities". InterfaceCompr FocusPhysiol 43 (51): 20140040403–428. doi:10.10981002/rsfscphy.2014c110063.0040 PMC 3951958. PMID 2528519923720292.</ref><ref name="VEGF aging brain" />