MutantOs miceratos defectivemutantes indeficientes en Ku70,orou Ku80, orou doubleratos mutantdobres micemutantes deficientdeficientes inen bothambas Ku70as andproteínas Ku80mostran exhibitun earlyenvellecemento agingtemperán.<ref name="pmid17875923">{{cite journal |vauthors=Li H, Vogel H, Holcomb VB, Gu Y, Hasty P |title=Deletion of Ku70, Ku80, or both causes early aging without substantially increased cancer |journal=Mol. Cell. Biol. |volume=27 |issue=23 |pages=8205–14 |year=2007 |pmid=17875923 |pmc=2169178 |doi=10.1128/MCB.00785-07 |url=}}</ref> A Theduración meandas lifespansvidas ofmedias thedas threetres mutantcepas mousede strainsratos weremutantes similareran to each othersimilares, at aboutdunhas 37 weekssemanas, comparedcomparadas tocoas 108 weekssemanas fordos theratos wild-typede control. de Sixtipo specificsalvaxe. signsExamináronse ofseis agingsignos wereespecíficos examinedde envellecemento, ande theos threetres mutantratos micemutantes weremostraban foundos tomesmos displaysignos thede sameenvellecemento agingque signsos asratos thede control mice, butpero ata aunha idade muchmoito earliermáis agetemperá. A Cancerincidencia incidencede wascancro notnon increasedse inincrementaba thenos mutantratos micemutantes. Estes Theseresultados resultssuxiren suggestque thata función de Ku functioné isimportante importantpara forasegurar longevitya assurancelonxevidade ande thatque thea vía [[NHEJ]] pathwayda ofreparación DNAdo repairADN (mediatedmediada bypor Ku) hasten aun keypapel roleclave inna repairingreparación DNAdas double-strandroturas breaksde thatdobre wouldfebra otherwisedo causeADN earlyque agingde non ser reparadas causarían envellecemento temperán.<ref>Bernstein H, Payne CM, Bernstein C, Garewal H, Dvorak K (2008). Cancer and aging as consequences of un-repaired DNA damage. In: New Research on DNA Damages (Editors: Honoka Kimura and Aoi Suzuki) Nova Science Publishers, Inc., New York, Chapter 1, pp. 1-47. open access, but read only https://www.novapublishers.com/catalog/product_info.php?products_id=43247 ISBN 978-1604565812</ref> (Also see [[DNA damage theory of aging#Inherited defects that cause premature aging|DNA damage theory of aging]].)
