Quinase dependente de ciclina: Diferenzas entre revisións
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In yeast and Drosophila, CKIs are strong inhibitors of S- and M-CDK, but do not inhibit G1/S-CDKs. During G1, high levels of CKIs prevent cell cycle events from occurring out of order, but do not prevent transition through the Start checkpoint, which is initiated through G1/S-CDKs. Once the cell cycle is initiated, phosphorylation by early G1/S-CDKs leads to destruction of CKIs, relieving inhibition on later cell cycle transitions. In mammalian cells, the CKI regulation works differently. Mammalian protein p27 (Dacapo in Drosophila) inhibits G1/S- and S-CDKs, but does not inhibit S- and M-CDKs.<ref name = "Morgan2007" />
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As CDKs que interveñen CDKs directamente na regulación do ciclocelular asócianse don pequenas proteínas de 9 a 13 [[dalton (unidade)|kDa]] chamadas Suk1 ou [[CKS1B|Cks]].<ref name = "Morgan1997" /> Estas proteínas son necesarias para o funcionamento das CDKs, pero o papel preciso que exercen non se coñece.<ref name = "Morgan1997" />
▲===Suk1 or Cks===
Cks1 únese ao lobo carboxi da CDK, e recoñece residuos fosforilados. Pode axudar ao complexo ciclina-CDK con substratos que teñen múltiples sitios de fosforilación ao incrementar a afinidade polo substrato.<ref name = "Morgan1997" />
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=== Activadores das CDKs que non son ciclinas ===
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