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== Tipos ==
'''TableTáboa 1:''' Known CDKs coñecidas, theirassúas [[cyclinciclina]]s partnersasociadas, ande theiras functionssúas infuncións theno humanser humano <ref name = "Morgan1997" /> ande consequencesas ofconsecuencias deletionda súa [[deleción]] inen miceratos.<ref name = "Satyanarayana2009">Satyanarayana, A; Kaldis. (2009). “Mammalian cell-cycle regulation: several Cdks, numerous cyclins, and diverse compensatory mechanisms” “Oncogene” 28:2925-2939</ref>
{| class="wikitable"
|-
! CDK !! CyclinCiclina partnerasociada !! FunctionFunción !! DeletionFenotipo Phenotypede indeleción Miceen ratos
|-
| Cdk1 || [[CyclinCiclina B]] || MFase phaseM || NoneNingún. ~E2.5.
|-
| Cdk2 || [[CyclinCiclina E]] || Transición G1/S transition || ReducedTamaño sizereducido, impartedproliferación neuralda progenitorcélula cellproxenitora proliferationneural. Viable, butpero tanto os machos bothcoma malesas &femias femalesson sterileestériles.
|-
| Cdk2 || [[CyclinCiclina A]] || SFase phaseS, G2fase phaseG2
|-
| Cdk3 || [[CyclinCiclina C]] || G1Fase phaseG1 ? || NoNingún defectsdefecto. Viable, fertilefértil.
|-
| Cdk4 || [[CyclinCiclina D]] || Fase G1 phase || ReducedTamaño sizereducido, insulin[[diabete]] deficientdeficiente diabetesen [[insulina]]. Viable, butpero tanto os machos bothcoma maleas &femias femaleson infertileinfértiles.
|-
| Cdk5 || [[CDK5R1|p35]] || TranscriptionTranscrición || SevereDefectos neurologicalneurolóxicos defectsgraves. DiedMorte immediatelyinmediata afterdespois birthde nacer.
|-
| Cdk6 || [[CyclinCiclina D]] || G1Fase phaseG1 ||
|-
| Cdk7 || [[CyclinCiclina H]] || CDK-activatingQuinase kinaseactivadora de CDK, transcriptiontranscrición
|-
| Cdk8 || [[CyclinCiclina C]] || TranscriptionTranscrición ||EmbryonicLetal lethalen fase embrionaria
|-
| Cdk9 || [[CyclinCiclina T]] || TranscriptionTranscrición ||EmbryonicLetal lethalen fase embrionaria
|-
| Cdk11 || CyclinCiclina L || ? || MitoticDefectos defectsmitóticos. E3.5.
|-
| ? || [[CyclinCiclina F]] || ? || DefectsDefectos inen extraembryonictecidos tissuesextraembrionais. E10.5.
|-
| ? || CyclinCiclina G || ? ||
|}
== As CDKs ande Cyclinsas inciclinas theno Cellciclo Cyclecelular ==
MostA ofmaioría thedos knowncomplexos cyclinciclina-CDK complexescoñecidos regulateregulan thea progressionprogresión through thedo [[cellciclo cyclecelular]]. AnimalAs cellscélulas containanimais atconteñen leastpolo ninemenos nove CDKs, fourcatro ofdas whichcales, CDK1, 2, 3, ande 4, areestán directlydirectamente involvedimplicadas innaregulación celldo cycleciclo regulationcelular.<ref name = "Morgan2007" /> InEn mammaliancélulas cellsde mamíferos, a CDK1, with itscoas partnerssúas cyclinciclinas A2 ande B1B asociadas, alonepode el cansó driveimpulsar theo cellciclo cyclecelular.<ref name = "Satyanarayana2009" /> Another oneOutra, a CDK7, isestá involvedimplicada indirectlyindirectamente ascomo theunha CDK-activatingquinase kinaseactivadora de CDK.<ref name = "Morgan2007" /> Cyclin-CDK complexes phosphorylate substrates appropriate for the particular cell cycle phase.<ref name = "Morgan1997" /> Cyclin-CDK complexes of earlier cell-cycle phase help activate cyclin-CDK complexes in later phase.<ref name = "Morgan2007" />
'''TableTáboa 2:''' CyclinsCiclinas ande CDKs bysegundo Cell-Cyclea Phasefase do ciclo celular
{| class="wikitable"
|-
! PhaseFase !! CyclinCiclina !! CDK
|-
| G0 || C || Cdk3
|}
'''TableTáboa 3:''' Cyclin-dependentQuinases kinasesdependentes thatde controlciclina theque cellcontrolan cycleo inciclo modelcelular organismsen [[organismo modelo|organismos modelo]].<ref name = "Morgan2007" />
{| class="wikitable"
|-
! SpeciesEspecie !! NameNome !! OriginalNome nameorixinal !! SizeTamaño (amino acidsaminoácidos) !! FunctionFunción
|-
| ''[[Saccharomyces cerevisiae]]'' || Cdk1 || Cdc28 || 298 || AllTodas cell-cycleas stagesfases do ciclo celular
|-
| ''[[Schizosaccharomyces pombe]]'' || Cdk1 || Cdc2 || 297 || AllTodas cell-cycles stagesfases do ciclo celular
|-
| ''[[Drosophila melanogaster]]'' || Cdk1 || Cdc2 || 297 || M
|-
| || Cdk2 || Cdc2c || 314 || G1/S, S, possiblyposiblemente M
|-
| || Cdk4 || Cdk4/6 || 317 || G1, promotespromove growtho crecemento
|-
| ''[[Xenopus laevis]]'' || Cdk1 || Cdc2 || 301 || M
|-
| || Cdk2 || || 297 || S, possiblyposiblemente M
|-
| ''[[Homo sapiens]]'' || Cdk1 || Cdc2 || 297 || M
|-
| || Cdk2 || || 298 || G1, S, possiblyposiblemente M
|-
| || Cdk4 || || 301 || G1
| || Cdk6 || || 326 || G1
|}
'''AUnha listlista ofde CDKs withcoa theirsúa regulatorproteína proteinreguladora, cyclinciclina orou other.outra:'''
*[[CDK1]]; [[cyclinciclina A]], [[cyclinciclina B]]
*[[Cyclin-dependentQuinase kinasedependente de ciclina 2|CDK2]]; [[cyclinciclina A]], [[cyclinciclina E]]
*{{Gene|CDK3}}; [[cyclinciclina C]]
*[[CDK4]]; [[cyclinciclina D1]], [[cyclinciclina D2]], [[cyclinciclina D3]]
*[[CDK5]]; [[CDK5R1]], [[CDK5R2]]. SeeVer alsotamén [[CDKL5]].
*[[CDK6]]; [[cyclinciclina D1]], [[cyclinciclina D2]], [[cyclinciclina D3]]
*[[CDK7]]; [[cyclinciclina H]]
*{{Gene|CDK8}}; [[cyclinciclina C]]
*[[CDK9]]; [[cyclinciclina T1]], [[cyclinciclina T2a]], [[cyclinciclina T2b]], [[cyclinciclina K]]
*{{Gene|CDK10}}
* CDK11 ({{Gene|CDC2L2}}) ; [[cyclinciclina L]]
* [[CDK12]]; [[cyclinciclina L]]
* CDK13 ({{Gene|CDC2L5}}) ; [[cyclinciclina L]]
== Regulación da actividade das CDK ==
==Regulation of CDK activity==
CDK levels remain relatively constant throughout the cell cycle and most regulation is post-translational. Most knowledge of CDK structure and function is based on CDKs of ''S. pombe'' (Cdc2), ''S. cerevisiae'' (CDC28), and vertebrates (CDC2 and CDK2). The four major mechanisms of CDK regulation are cyclin binding, [[CDK-activating kinase|CAK]] phosphorylation, regulatory inhibitory phosphorylation, and binding of CDK inhibitory subunits (CKIs).<ref name = "Morgan1995">Morgan, David O. (1995). “Principles of CDK regulation.” “Nature” 374:131-133.</ref>
|}
-->
== Notas ==
{{Listaref}}
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