Fosfolipase A2: Diferenzas entre revisións

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Miguelferig (conversa | contribucións)
Miguelferig (conversa | contribucións)
Liña 94:
En ratos, as sPLA2 do grupo III están implicadas na maduración dos [[espermatozoide]]s,<ref>{{cite journal | vauthors = Sato H, Taketomi Y, Isogai Y, Miki Y, Yamamoto K, Masuda S, Hosono T, Arata S, Ishikawa Y, Ishii T, Kobayashi T, Nakanishi H, Ikeda K, Taguchi R, Hara S, Kudo I, Murakami M | title = Group III secreted phospholipase A2 regulates epididymal sperm maturation and fertility in mice | journal = The Journal of Clinical Investigation | volume = 120 | issue = 5 | pages = 1400–14 | date = May 2010 | pmid = 20424323 | pmc = 2860917 | doi = 10.1172/JCI40493 }}</ref> e as do grupo X crese que están implicadas na [[capacitación]] dos espermatozoides.<ref>{{cite journal | vauthors = Escoffier J, Jemel I, Tanemoto A, Taketomi Y, Payre C, Coatrieux C, Sato H, Yamamoto K, Masuda S, Pernet-Gallay K, Pierre V, Hara S, Murakami M, De Waard M, Lambeau G, Arnoult C | title = Group X phospholipase A2 is released during sperm acrosome reaction and controls fertility outcome in mice | journal = The Journal of Clinical Investigation | volume = 120 | issue = 5 | pages = 1415–28 | date = May 2010 | pmid = 20424324 | pmc = 2860919 | doi = 10.1172/JCI40494 }}</ref>
 
A sPLA2 promove a inflamación en mamíferos ao catalizar o primeiro paso da [[vía do ácido araquidónico]] ao degradar [[fosfolípido]]s, o que ten como resultado a formación de [[ácido graxo|ácidos graxos]] incluíndo o ácido araquidónico. Este ácido araquidónico é despois metabolizado para formar varias moléculas inflamatorias e [[tromboxenicidade|tromboxénicas]]. Os niveis excesivos de sPLA2 crese que contribúen a varias [[doenza inflamatoria|doenzas inflamatorias]], e promoven a inflamación vascular correlacionada con eventos coronarios na [[enfermidade arterial coronaria]] e a [[síndrome coronaria aguda]],<ref name="pmid21098459">{{cite journal | vauthors = Mallat Z, Lambeau G, Tedgui A | title = Lipoprotein-associated and secreted phospholipases A₂ in cardiovascular disease: roles as biological effectors and biomarkers | journal = Circulation | volume = 122 | issue = 21 | pages = 2183–200 | date = Nov 2010 | pmid = 21098459 | doi = 10.1161/CIRCULATIONAHA.110.936393 }}</ref> e posiblemente acaba causando [[síndrome de dificultade respiratoria aguda]]<ref name="pmid20351613">{{cite journal | vauthors = De Luca D, Minucci A, Cogo P, Capoluongo ED, Conti G, Pietrini D, Carnielli VP, Piastra M | title = Secretory phospholipase A₂ pathway during pediatric acute respiratory distress syndrome: a preliminary study | journal = Pediatric Critical Care Medicine | volume = 12 | issue = 1 | pages = e20-4 | date = Jan 2011 | pmid = 20351613 | doi = 10.1097/PCC.0b013e3181dbe95e }}</ref> e a progresión da [[amigdalite]]<ref>{{cite journal | vauthors = Ezzeddini R, Darabi M, Ghasemi B, Jabbari Moghaddam Y, Jabbari Y, Abdollahi S, Rashtchizadeh N, Gharahdaghi A, Darabi M, Ansarin M, Shaaker M, Samadi A, Karamravan J | title = Circulating phospholipase-A2 activity in obstructive sleep apnea and recurrent tonsillitis | journal = International Journal of Pediatric Otorhinolaryngology | volume = 76 | issue = 4 | pages = 471–4 | date = Apr 2012 | pmid = 22297210 | doi = 10.1016/j.ijporl.2011.12.026 }}</ref>
 
En nenos os niveis excesivos de sPLA2 foron asociados coa inflamación que se cre que exacerba o [[asma (doenza)|asma]]<ref>{{cite journal | vauthors = Henderson WR, Oslund RC, Bollinger JG, Ye X, Tien YT, Xue J, Gelb MH | title = Blockade of human group X secreted phospholipase A2 (GX-sPLA2)-induced airway inflammation and hyperresponsiveness in a mouse asthma model by a selective GX-sPLA2 inhibitor | journal = The Journal of Biological Chemistry | volume = 286 | issue = 32 | pages = 28049–55 | date = Aug 2011 | pmid = 21652694 | pmc = 3151050 | doi = 10.1074/jbc.M111.235812 }}</ref> e a inflamación da superficie celular ([[ollo seco]]).<ref name="pmid21519031">{{cite journal | vauthors = Wei Y, Epstein SP, Fukuoka S, Birmingham NP, Li XM, Asbell PA | title = sPLA2-IIa amplifies ocular surface inflammation in the experimental dry eye (DE) BALB/c mouse model | journal = Investigative Ophthalmology & Visual Science | volume = 52 | issue = 7 | pages = 4780–8 | date = Jun 2011 | pmid = 21519031 | pmc = 3175946 | doi = 10.1167/iovs.10-6350 }}</ref>