Factor de crecemento endotelial vascular: Diferenzas entre revisións

A hipoxia regula á alza fortemente a expresión de VEGF e este exerce un efecto neuroprotector sobre as neuronas hipóxicas.<ref name="NHM IGF-1 VEGF">Malenka RC, Nestler EJ, Hyman SE (2009). Sydor A, Brown RY, ed. Molecular Neuropharmacology: A Foundation for Clinical Neuroscience (2nd ed.). New York: McGraw-Hill Medical. pp. 221, 412. ISBN 9780071481274.</ref> O exercicio aeróbico incrementa a biosíntese de VEGF nos tecidos periféricos, que despois cruza a [[barreira hematoencefálica]] e promove a neuroxénese e anxioxénese no [[sistema nervioso central]].<ref name="Cerebral hemodynamics and AD">{{cite journal |author = Tarumi T, Zhang R | title = Cerebral hemodynamics of the aging brain: risk of Alzheimer disease and benefit of aerobic exercise | journal = Front Physiol | volume = 5 | issue = | pages = 6 | date = January 2014 | pmid = 24478719 | pmc = 3896879 | doi = 10.3389/fphys.2014.00006 }}</ref><ref name="Fitness mechanism" /><ref name="VEGF aging brain">{{cite journal | author = Bouchard J, Villeda SA | title = Aging and brain rejuvenation as systemic events | journal = J. Neurochem. | volume = 132 | issue = 1 | pages = 5–19 | year = 2015 | pmid = 25327899 | pmc = 4301186 | doi = 10.1111/jnc.12969 }}</ref> Os incrementos inducidos polo exercicio na sinalización por VEGF melloran o volume sanguíneo cerebral e contribúen á neuroxénese inducida polo exercicio no [[hipocampo]].<ref name="Comprehensive review">Gomez-Pinilla F, Hillman C (January 2013). "The influence of exercise on cognitive abilities". Compr Physiol 3 (1): 403–428. doi:10.1002/cphy.c110063. PMC 3951958. PMID 23720292. </ref><ref name="Fitness mechanism" >Silverman MN, Deuster PA (October 2014). "Biological mechanisms underlying the role of physical fitness in health and resilience". Interface Focus 4 (5): 20140040. doi:10.1098/rsfs.2014.0040. PMID 25285199</ref><ref name="VEGF aging brain" />