Factor de crecemento endotelial vascular: Diferenzas entre revisións

A hipoxia regula á alza fortemente a expresión de VEGF e este exerce un efecto neuroprotector sobre as neuronas hipóxicas.<ref name="NHM IGF-1 VEGF" /> O exercicio aeróbico incrementa a biosíntese de VEGF nos tecidos periféricos, que despois cruza a [[barreira hematoencefálica]] e promove a neuroxénese e anxioxénese no [[sistema nervioso central]].<ref name="Cerebral hemodynamics and AD">{{cite journal | vauthors = Tarumi T, Zhang R | title = Cerebral hemodynamics of the aging brain: risk of Alzheimer disease and benefit of aerobic exercise | journal = Front Physiol | volume = 5 | issue = | pages = 6 | date = January 2014 | pmid = 24478719 | pmc = 3896879 | doi = 10.3389/fphys.2014.00006 | quote = Exercise-related improvements in brain function and structure may be conferred by the concurrent adaptations in vascular function and structure. Aerobic exercise increases the peripheral levels of growth factors (e.g., BDNF, IFG-1, and VEGF) which cross the blood-brain barrier (BBB) and stimulate neurogenesis and angiogenesis (Trejo et al., 2001; Lee et al., 2002; Fabel et al., 2003; Lopez-Lopez et al., 2004).}}</ref><ref name="Fitness mechanism" /><ref name="VEGF aging brain">{{cite journal | vauthorsauthor = Bouchard J, Villeda SA | title = Aging and brain rejuvenation as systemic events | journal = J. Neurochem. | volume = 132 | issue = 1 | pages = 5–19 | year = 2015 | pmid = 25327899 | pmc = 4301186 | doi = 10.1111/jnc.12969 }}</ref> Os incrementos inducidos polo exercicio na sinalización por VEGF melloran o volume sanguíneo cerebral e contribúen á neuroxénese inducida polo exercicio no [[hipocampo]].<ref name="Comprehensive review" /><ref name="Fitness mechanism" /><ref name="VEGF aging brain" />