3-hidroxi-3-metilglutaril-coencima A: Diferenzas entre revisións
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Liña 1:
{{Chembox
| verifiedrevid = 450656813
|ImageFile=HMG coenzyme A.svg
|ImageSize=300px
|IUPACName=ácido (9R,21S)-1-[(2R,3S,4R,5R)-5-
(6-amino-9H-purin-9-il)-4-hidroxi-
3-(fosfonooxi)tetrahidrofuran-2-il]-
3,5,9,21-tetrahidroxi-8,8,21-trimetil-
10,14,19-trioxo-2,4,6-trioxa-18-tia-
11,15-diaza-3,5-diiosiatricosan-23-
oico 3,5-dióxido
|OtherNames=
|Section1= {{Chembox Identifiers
| ChemSpiderID_Ref =
| ChemSpiderID = 392859
| InChI = 1/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1
| InChIKey = CABVTRNMFUVUDM-VRHQGPGLBX
| StdInChI_Ref =
| StdInChI = 1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1
| StdInChIKey_Ref =
| StdInChIKey = CABVTRNMFUVUDM-VRHQGPGLSA-N
| CASNo_Ref =
| CASNo=1553-55-5
| PubChem = 445127
| ChEBI_Ref =
| ChEBI = 61659
| SMILES = O=C(O)C[C@@](O)(C)CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(=O)(O)OP(=O)(O)OC[C@H]3O[C@@H](n2cnc1c(ncnc12)N)[C@H](O)[C@@H]3OP(=O)(O)O
| MeSHName=HMG-CoA
}}
|Section2= {{Chembox Properties
| Formula=C<sub>27</sub>H<sub>44</sub>N<sub>7</sub>O<sub>20</sub>P<sub>3</sub>S
| MolarMass=911,661 g/mol
| Appearance=
| Density=
| MeltingPt=
| BoilingPt=
| Solubility=
}}
|Section3= {{Chembox Hazards
| MainHazards=
| FlashPt=
| Autoignition=
}}
}}
O '''3-hidroxi-3-metilglutaril-coencima A''' <ref>PubChem compound [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=445127 3-hydroxy-3-methylglutaryl-coenzyme A]</ref> <ref>CHEBI [https://www.ebi.ac.uk/chebi/searchId.do?chebiId=61659 (3S)-3-hydroxy-3-methylglutaryl-coenzyme A]</ref>, ou '''HMG-CoA'''<ref>MeSH name [http://www.nlm.nih.gov/cgi/mesh/2007/MB_cgi?mode=&term=HMG-CoA]</ref>, tamén chamado '''β-hidroxi-β-metilglutaril-coencima A''' (ás veces abreviado como hidroximetilglutaril-CoA) é unha molécula formada por un hidroxiácido metilado de 4 carbonos unido ao [[coencima A]] (derivado dun [[nucleótido]]). Funciona como un intermediato na ruta de formación de [[corpo cetónico|corpos cetónicos]] ([[cetoxénese]]) e na vía do [[mevalonato]] para a formación de [[terpeno]]s e [[esteroide]]s, onde se forma a partir de [[acetoacetil-CoA]] e [[acetil-CoA]]. Tamén intervén como intermediario no metabolismo do aminoácido [[leucina]], onde o seu precursor é o [[3-metilglutaconil-CoA]].
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