Interferón gamma: Diferenzas entre revisións

O '''interferón gamma''' ('''IFNγ''' ou '''IFN-γ''') é unha [[proteína]] [[citocina]] [[dímero|dímera]] soluble regulatoria, que é o único membro dos '''interferóns de tipo II'''.<ref name="pmid6180322">{{cite journal | author = Gray PW, Goeddel DV | title = Structure of the human immune interferon gene | journal = Nature | volume = 298 | issue = 5877 | pages = 859–63 | date = August 1982 | pmid = 6180322 | doi = 10.1038/298859a0 | url = }}</ref> TheEste existence of this interferon[[interferón]], whichque earlyinicialmente inera itscoñecido historycomo wasinterferón known as immune interferoninmunitario, wasfoi describeddescrito bypor E. F. Wheelock ascomo aun productproduto ofde human[[leucocito]]s leukocyteshumanos stimulatedestimulados withcon phytohemagglutininfitohemaglutinina, ande bypor othersoutros asautores acomo productun ofproduto antigen-stimulatedde lymphocyteslinfocitos estimulados por [[antíxeno]]s <ref>Wheelock, EF, Interferon-like virus inhibitor induced in human leukocytes by phytohemagglutinin. ''Science'' 149, 310-311, 1965. It was also shown to be produced in human lymphocytes </ref><ref>{{cite journal | author = Green JA, Cooperband SR, Kibrick S | title = Immune specific induction of interferon production in cultures of human blood lymphocytes | journal = Science | volume = 164 | issue = 3886 | pages = 1415-1417 | year = 1969 | pmid = 5783715 | doi = 10.1126/science.164.3886.1415 }}</ref> orou tuberculin-sensitizedde mouse[[linfocito]]s peritonealperitoneais lymphocytesde rato sensibilizados á [[tuberculina]]<ref>{{cite journal | author = Milstone LM, Waksman BH | title = Release of virus inhibitor from tuberculin-sensitized peritoneal cells stimulated by antigen | journal = J Immunol | volume = 105 | issue = 5 | pages = 1068–1071 | year = 1970 | pmid = 4321289 }}</ref> challengedexpostos witha [[Mantoux_testproba de Mantoux|PPD]]; theos resultingsobrenadantes supernatantsresultantes wereinhibían showno tocrecemento inhibitdo growth[[virus ofda estomatite vesicular]]. stomatitisAqueles virus.primeiros informes Thosetamén reportscontiñan alsoas containedobservacións thebásicas basichoxe observationsubxacentes underlyingao theextendido nowemprego widelyactual employeddo interferonensaio gammade releaseliberación assayde usedinterferón togamma testusado forcomo tuberculosis.proba para a [[tuberculose]]. InNos humanshumanos, theo IFNγ proteinestá iscodificado encodedno by the[[xene]] '''''IFNG''''' do [[genecromosoma 12]].<ref name="pmid6403645">{{cite journal | author = Naylor SL, Sakaguchi AY, Shows TB, Law ML, Goeddel DV, Gray PW | title = Human immune interferon gene is located on chromosome 12 | journal = J. Exp. Med. | volume = 157 | issue = 3 | pages = 1020–7 | date = March 1983 | pmid = 6403645 | pmc = 2186972 | doi = 10.1084/jem.157..1020 | url = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: IFNGR2 | url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3460 | accessdate = }}</ref>