Interleucina 8: Diferenzas entre revisións

A interleucina 8 está a miúdo asociada coa [[inflamación]]. Como exemplo, foi citada como mediador proinflamatorio na [[xinxivite]]<ref>Haake, SK, Huang, GTJ: Molecular Biology of the host-Microbe Interaction in Periodontal Diseases (Selected Topics). In Newman, Takei, Carranza, editors: ''Clinical Periodontology'', 9th Edition. Philadelphia: W.B.Saunders Co. 2002. páxina 162.</ref> e na [[psoriase]] [http://www.ucsf.edu/dpsl/psoriasis.html]. A [[secreción]] de interleucina 8 increméntase polo [[estrés oxidativo]], o cal causa o recrutamente de células inflamatorias e induce un maior incremento dos mediadores do estrés oxidativo, o que a fai un parámetro clave da inflamación localizada.<ref name="pmid10477716">{{cite journal | author = Vlahopoulos S, Boldogh I, Casola A, Brasier AR | title = Nuclear factor-kappaB-dependent induction of interleukin-8 gene expression by tumor necrosis factor alpha: evidence for an antioxidant sensitive activating pathway distinct from nuclear translocation | journal = Blood | volume = 94 | issue = 6 | pages = 1878–89 | year = 1999 | pmid = 10477716 | doi = }}</ref> A IL-8 está asociada coa [[obesidade]].<ref name=ImmunologicProfile>{{cite journal | author = Sharabiani MT, Vermeulen R, Scoccianti C, Hosnijeh FS, Minelli L, Sacerdote C, Palli D, Krogh V, Tumino R, Chiodini P, Panico S, Vineis P | title = Immunologic profile of excessive body weight | journal = Biomarkers | volume = 16 | issue = 3 | pages = 243–51 | year = 2011 | pmid = 21506696 | doi = 10.3109/1354750X.2010.547948 }}</ref>

 

 

Segundo algúns estudos, se unha muller preñada ten niveis altos de interleucina 8, aumenta o risco de [[esquizofrenia]] na súa descendencia.<ref name="pmid15121655">{{cite journal | author = Brown AS, Hooton J, Schaefer CA, Zhang H, Petkova E, Babulas V, Perrin M, Gorman JM, Susser ES | title = Elevated maternal interleukin-8 levels and risk of schizophrenia in adult offspring | journal = Am J Psychiatry | volume = 161 | issue = 5 | pages = 889–95 | year = 2004 | pmid = 15121655 | doi = 10.1176/appi.ajp.161.5.889 }}</ref> Ter niveis altos de IL-8 reduce a probabilidade de ter respostas positivas á medicación antipsicótica na esquizofrenia.<ref name="pmid15291683">{{cite journal | author = Zhang XY, Zhou DF, Cao LY, Zhang PY, Wu GY, Shen YC | title = Changes in serum interleukin-2, -6, and -8 levels before and during treatment with risperidone and haloperidol: relationship to outcome in schizophrenia | journal = J Clin Psychiatry | volume = 65 | issue = 7 | pages = 940–7 | year = 2004 | pmid = 15291683 | doi = 10.4088/JCP.v65n0710 }}</ref>