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A interleucina 8 está a miúdo asociada coa [[inflamación]]. Como exemplo, foi citada como mediador proinflamatorio na [[xinxivite]]<ref>Haake, SK, Huang, GTJ: Molecular Biology of the host-Microbe Interaction in Periodontal Diseases (Selected Topics). In Newman, Takei, Carranza, editors: ''Clinical Periodontology'', 9th Edition. Philadelphia: W.B.Saunders Co. 2002. páxina 162.</ref> e na [[psoriase]] [http://www.ucsf.edu/dpsl/psoriasis.html]. A [[secreción]] de interleucina 8 increméntase polo [[estrés oxidativo]], o cal causa o recrutamente de células inflamatorias e induce un maior incremento dos mediadores do estrés oxidativo, o que a fai un parámetro clave da inflamación localizada.<ref name="pmid10477716">{{cite journal | author = Vlahopoulos S, Boldogh I, Casola A, Brasier AR | title = Nuclear factor-kappaB-dependent induction of interleukin-8 gene expression by tumor necrosis factor alpha: evidence for an antioxidant sensitive activating pathway distinct from nuclear translocation | journal = Blood | volume = 94 | issue = 6 | pages = 1878–89 | year = 1999 | pmid = 10477716 | doi = }}</ref> A IL-8 está asociada coa [[obesidade]].<ref name=ImmunologicProfile>{{cite journal | author = Sharabiani MT, Vermeulen R, Scoccianti C, Hosnijeh FS, Minelli L, Sacerdote C, Palli D, Krogh V, Tumino R, Chiodini P, Panico S, Vineis P | title = Immunologic profile of excessive body weight | journal = Biomarkers | volume = 16 | issue = 3 | pages = 243–51 | year = 2011 | pmid = 21506696 | doi = 10.3109/1354750X.2010.547948 }}</ref>
 
A IL-8 tamén foi implicada no cancro colorrectal ao actuar como un [[factor de crecemento]] [[autácrinoautócrino]] para as liñas celulares de carcinoma de colon<ref name="BrewErikson2000">{{cite journal | author = Brew R, Erikson JS, West DC, Kinsella AR, Slavin J, Christmas SE | title = Interleukin-8 as an autocrine growth factor for human colon carcinoma cells in vitro | journal = Cytokine | volume = 12 | issue = 1 | pages = 78–85 | year = 2000 | pmid = 10623446 | doi = 10.1006/cyto.1999.0518 }}</ref> ou a promoción da división e posible migración na que están implicadas [[metaloproteinase]]s e o [[EGF]].<ref name="ItohJoh2005">{{cite journal | author = Itoh Y, Joh T, Tanida S, Sasaki M, Kataoka H, Itoh K, Oshima T, Ogasawara N, Togawa S, Wada T, Kubota H, Mori Y, Ohara H, Nomura T, Higashiyama S, Itoh M | title = IL-8 promotes cell proliferation and migration through metalloproteinase-cleavage proHB-EGF in human colon carcinoma cells | journal = Cytokine | volume = 29 | issue = 6 | year = 2005 | pmid = 15749028 | doi = 10.1016/j.cyto.2004.11.005 }}</ref>
 
Segundo algúns estudos, se unha muller preñada ten niveis altos de interleucina 8, aumenta o risco de [[esquizofrenia]] na súa descendencia.<ref name="pmid15121655">{{cite journal | author = Brown AS, Hooton J, Schaefer CA, Zhang H, Petkova E, Babulas V, Perrin M, Gorman JM, Susser ES | title = Elevated maternal interleukin-8 levels and risk of schizophrenia in adult offspring | journal = Am J Psychiatry | volume = 161 | issue = 5 | pages = 889–95 | year = 2004 | pmid = 15121655 | doi = 10.1176/appi.ajp.161.5.889 }}</ref> Ter niveis altos de IL-8 reduce a probabilidade de ter respostas positivas á medicación antipsicótica na esquizofrenia.<ref name="pmid15291683">{{cite journal | author = Zhang XY, Zhou DF, Cao LY, Zhang PY, Wu GY, Shen YC | title = Changes in serum interleukin-2, -6, and -8 levels before and during treatment with risperidone and haloperidol: relationship to outcome in schizophrenia | journal = J Clin Psychiatry | volume = 65 | issue = 7 | pages = 940–7 | year = 2004 | pmid = 15291683 | doi = 10.4088/JCP.v65n0710 }}</ref>
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