Diferenzas entre revisións de «Interleucina 8»

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{{entradución}}
{{proteína
 
| Nome = Quimioquina (motivo C-X-C) ligando 8
| image = IL8 Solution Structure.rsh.png
| width =
| caption = {{PDB|1IL8}}
| Símbolo = CXCL8
| AltSymbols =GCP-1; GCP1; IL8; LECT; LUCT; LYNAP; MDNCF; MONAP; NAF; NAP-1; NAP1
| ATC_prefix=
| ATC_suffix=
| ATC_supplemental=
| CAS_number=
| CAS_supplemental=
| DrugBank=
| EntrezGene = 3576
| HGNCid =
| OMIM = 146930
| PDB =
| RefSeq = NP_000575
| UniProt = P10145
| ECnumber =
| Cromosoma = 4
| Brazo =
| Banda =
| LocusSupplementaryData = :(74.61 – 74.61 Mb)
}}
A '''interleucina 8''' ('''IL-8''' ou IL8), tamén chamada '''CXCL8''', é unha [[quimiocina]] producida polos [[macrófago]]s e outros tipos celulares como as [[epitelio|células epiteliais]], células do [[músculo liso]] das vías aéreas<ref name="pmid10873157">{{cite journal | author = Hedges JC, Singer CA, Gerthoffer WT | title = Mitogen-activated protein kinases regulate cytokine gene expression in human airway myocytes | journal = Am. J. Respir. Cell Mol. Biol. | volume = 23 | issue = 1 | pages = 86–94 | year = 2000 | pmid = 10873157 | doi = 10.1165/ajrcmb.23.1.4014 }}</ref> e células [[endotelio|endoteliai]]. As células endoteliais almacenan IL-8 nas súas vesículas de almacenamento chamadas [[corpo de Weibel-Palade|corpos de Weibel-Palade]].<ref name="pmid9802987">{{cite journal | author = Wolff B, Burns AR, Middleton J, Rot A | title = Endothelial cell "memory" of inflammatory stimulation: human venular endothelial cells store interleukin 8 in Weibel-Palade bodies | journal = J. Exp. Med. | volume = 188 | issue = 9 | pages = 1757–62 | year = 1998 | pmid = 9802987 | pmc = 2212526 | doi = 10.1084/jem.188.9.1757 }}</ref><ref name="pmid9802986">{{cite journal | author = Utgaard JO, Jahnsen FL, Bakka A, Brandtzaeg P, Haraldsen G | title = Rapid secretion of prestored interleukin 8 from Weibel-Palade bodies of microvascular endothelial cells | journal = J. Exp. Med. | volume = 188 | issue = 9 | pages = 1751–6 | year = 1998 | pmid = 9802986 | pmc = 2212514 | doi = 10.1084/jem.188.9.1751 }}</ref> Nos humanos, a [[proteína]] interleucina 8 está codificada no [[xene]] ''IL8'' do [[cromosoma 4]].<ref name="pmid1967588">{{cite journal | author = Modi WS, Dean M, Seuanez HN, Mukaida N, Matsushima K, O'Brien SJ | title = Monocyte-derived neutrophil chemotactic factor (MDNCF/IL-8) resides in a gene cluster along with several other members of the platelet factor 4 gene superfamily | journal = Hum. Genet. | volume = 84 | issue = 2 | pages = 185–7 | year = 1990 | pmid = 1967588 | doi = 10.1007/BF00208938 }}</ref> A IL-8 é producida inicialmente como un pçeptido precursor de 99 [[aminoácido]]s, que posteriormente sofre unha clivaxe para dar lugar a varias [[isoforma]]s activas de IL-8.<ref name="Brat DJ 2005. pages 122-133">Brat DJ, Bellail AC, and Van Meir EG. 2005. The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis. ''Neuro-oncology''. 7(2), páxinas 122-133</ref> En cultivo, a principal forma segregada polos macrófagos é un pçeptido de 72 aminoácidos.<ref name="Brat DJ 2005. pages 122-133"/>
 
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