Carapucha 5': Diferenzas entre revisións
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Liña 24:
==Encimas implicados==
O [[complexo encimático para a adición da carapucha]] (''Capping Enzyme Complex'', CEC) necesario para a formación da carapucha está unido á [[ARN polimerase II]] antes de que empece a [[transcrición xenética|transcrición]]. Axiña que o extremo 5' do novo transcrito emerxe durante a transcrición, os encimas transfírense a el e empezan a formar a carapucha (este é un mecanismo similar ao que se produce na [[poliadenilación]]).]]).<ref>{{cite journal|last1=Cho|first1=E.-J.|last2=Takagi|first2=T.|last3=Moore|first3=C. R.|last4=Buratowski|first4=S.|title=mRNA capping enzyme is recruited to the transcription complex by phosphorylation of the RNA polymerase II carboxy-terminal domain|journal=Genes & Development|date=15 December 1997|volume=11|issue=24|pages=3319–3326|doi=10.1101/gad.11.24.3319|url=http://genesdev.cshlp.org/content/11/24/3319.short|accessdate=23 November 2014}}</ref><ref name=fabrega>{{cite journal|last1=Fabrega|first1=Carme|last2=Shen|first2=Vincent|last3=Shuman|first3=Stewart|last4=Lima|first4=Christopher D.|title=Structure of an mRNA Capping Enzyme Bound to the Phosphorylated Carboxy-Terminal Domain of RNA Polymerase II|journal=Molecular Cell|date=June 2003|volume=11|issue=6|pages=1549–1561|doi=10.1016/S1097-2765(03)00187-4|url=http://www.sciencedirect.com/science/article/pii/S1097276503001874|accessdate=23 November 2014}}</ref><ref>{{cite journal|last1=Ho|first1=C.|title=An essential surface motif (WAQKW) of yeast RNA triphosphatase mediates formation of the mRNA capping enzyme complex with RNA guanylyltransferase|journal=Nucleic Acids Research|date=15 December 1999|volume=27|issue=24|pages=4671–4678|doi=10.1093/nar/27.24.4671|url=http://nar.oxfordjournals.org/content/27/24/4671.short|accessdate=23 November 2014}}</ref><ref name=hirose>{{cite journal|last1=Hirose|first1=Yutaka|last2=Manley|first2=James L|title=RNA polymerase II and the integration of nuclear events|journal=Genes & Dev|date=2000|volume=14|pages=1415–1429|doi=10.1101/gad.14.12.1415|url=http://genesdev.cshlp.org/content/14/12/1415.full|accessdate=23 November 2014}}</ref>
Os [[encima]]s para a formación da carapucha soamente poden unirse á [[ARN polimerase II]] asegurando así a especificidade para só eses transcritos, que son case exclusivamente [[ARNm]].
<ref name=fabrega /><ref name=hirose />
==Función da carapucha 5′==
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