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==Rutas sintéticas==
IndoleO andindol itse derivativesos canseus alsoderivados bepoden synthesizedtamén bysintetizarse apor varietydiversos of methodsmétodos.<ref name="gribble2000">{{cite journal|author = Gribble G. W.|journal = [[J. Chem. Soc. Perkin Trans. 1]] |year = 2000|doi = 10.1039/a909834h|title = Recent developments in indole ring synthesis—methodology and applications|page = 1045|issue = 7}}</ref><ref name="cacchi2005">{{cite journal|author = Cacchi, S.; Fabrizi, G.|journal = [[Chem. Rev.]]|doi = 10.1021/cr040639b|pmid = 16011327|title = Synthesis and Functionalization of Indoles Through Palladium-catalyzed Reactions|year = 2005|volume = 105|issue = 7|page = 2873}}</ref><ref name="humphrey2006">{{cite journal|author = Humphrey, G. R.; Kuethe, J. T.|journal = [[Chem. Rev.]]|doi = 10.1021/cr0505270|pmid = 16836303|title = Practical Methodologies for the Synthesis of Indoles|year = 2006|volume = 106|issue = 7|page = 2875}}</ref>
 
A principais rutas de síntese industrial do indol empezan a partir da [[anilina]] por medio dunha reacción en fase de vapor co [[etilén glicol]] en presenza de [[catalizador]]es:
The main industrial routes start from [[aniline]] via vapor-phase reaction with [[ethylene glycol]] in the presence of [[catalyst]]s:
 
:[[FileFicheiro:Indole from aniline and ethylene glycol.jpg|350px|ReactionReacción ofda [[anilineanilina]] ande o [[ethyleneetilén glycolglicol]] topara givedar indoleindol.]]
 
InEn generalxeral, reactionsas arereaccións conductedrealízanse betweenentre os 200 ande os 500&nbsp;°C. YieldsOs canrendementos bepoden aschegar high asao 60%. OtherOutros precursorsprecursores todo indoleindol includeson formyltoluidinea formiltoluidina, a 2-ethylanilineetilanilina, ande o 2-(2-nitrophenylnitrofenil)ethanoletanol, alltodos ofos whichcales undergosofren cyclizationsciclacións.<ref>Gerd Collin and Hartmut Höke “Indole” Ullmann's Encyclopedia of Industrial Chemistry 2002, Wiley-VCH, Weinheim. {{DOI| 10.1002/14356007.a14_167}} [http://onlinelibrary.wiley.com/doi/10.1002/14356007.a14_167/abstract;jsessionid=CF4D9499484346D8D5A91ED679233D67.f03t01].</ref> Many other methods have beenDesenvolvéronse developedmoitos thatoutros aremétodos applicableaplicables.
 
===Síntese do indol de Leimgruber-Batcho===
174.329

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